1. Mucosal Leishmania infantum infection.
- Author
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Richter J, Hanus I, Häussinger D, Löscher T, and Harms G
- Subjects
- Adult, Aged, Amphotericin B administration & dosage, Antiprotozoal Agents administration & dosage, Esophagus pathology, Europe, Female, Humans, Leishmaniasis, Mucocutaneous drug therapy, Male, Middle Aged, Mouth Mucosa pathology, Nasal Mucosa pathology, Phosphorylcholine administration & dosage, Phosphorylcholine analogs & derivatives, Treatment Outcome, Leishmania infantum isolation & purification, Leishmaniasis, Mucocutaneous diagnosis, Leishmaniasis, Mucocutaneous parasitology
- Abstract
Mucosal leishmaniasis is a well-known clinical manifestation of infections caused by species belonging to the Leishmania (Viannia) subgenus in Central and South America but not of Leishmania species endemic in the so-called Old World. We report on three cases of mucosal leishmaniasis caused by Leishmania (Leishmania) infantum contracted in southern Europe. Two patients were immunocompromised; one patient had no underlying condition. Lesions were located in the oral mucosa, oesophagus and nose. All lesions relapsed under standard treatment with liposomal amphotericin B. A cure was achieved after secondary and extended treatment with liposomal amphotericin B or miltefosine. Mucosal leishmaniasis contracted in southern Europe has to be considered in the differential diagnosis of lesions in the naso-buccal-oesophageal mucosa and may occur in previously healthy persons.
- Published
- 2011
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