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Purpose: The aim of this article is to analyse the concepts of national and European identities through a multidisciplinary lens and to examine empirically how schools develop those identities in adolescents. Method: The study employs data from the "International Civic and Citizenship Education Study 2016." Correlation and regression analyses are conducted with data from over 45,000 students from fourteen different European educational systems. Country-specific weighted statistical analyses are conducted. Findings: A combination of perspectives from the fields of psychology, political culture, and civic and citizenship education is useful to reflect upon the dimensions and desirability of overarching identities. Formal learning opportunities are shown to be particularly relevant for fostering a European identity. Positive relationships between students and teachers and between students statistically predict stronger identities. Practical implications: Good social relationships at school help to develop national and European identities. Moreover, the development of a European identity especially depends upon its explicit inclusion in the curriculum. Teachers should guide students to reflect on the meaning and content of tolerant and complex national and European identities.

Single phenological measures, like the average rate of phenological advancement, may be insufficient to explain how climate change is driving trends in animal populations. Here, we develop a multifactorial concept of spring phenology—including the onset of spring, spring duration, interannual variability, and their temporal changes—as a driver for population dynamics of migratory terrestrial species in seasonal environments. Using this conceptual model, we found that effects of advancing spring phenology on animal populations may be buffered or amplified depending on the duration and interannual variability of spring green‐up, and those effects are modified by evolutionary and plastic adaptations of species. Furthermore, we compared our modelling results with empirical data on normalized difference vegetation index‐based spring green‐up phenology and population trends of 106 European landbird finding similar associations. We conclude how phenological changes are expected to affect migratory bird populations across Europe and identify regions that are particularly prone to suffer population declines. [ABSTRACT FROM AUTHOR]

The article discusses the progress and achievements of the young European Federation of Immunological Societies (yEFIS) network over the past three years. The network, which supports and empowers early career researchers in the field of immunology, has experienced significant growth and now has over 770 registered members. The article highlights the establishment of national young immunologist groups throughout Europe and the growing recognition and influence of yEFIS within the European immunology community. The article also discusses the various working groups within yEFIS, including the Communication Working Group, the Career Development and Education Working Group, the European Journal of Immunology Working Group, and the Equity and Diversity Working Group. These groups have been instrumental in fostering collaboration, providing support, and promoting diversity and inclusion within the field of immunology. The article concludes by discussing the upcoming yEFIS symposium and the network's collaborations with other societies and organizations. [Extracted from the article]

Sunflower (Helianthus annuus L.) is the second most important oil seed crop in Europe. The seeds are used as confection seeds and, more importantly, to generate an edible vegetable oil, which in normal varieties is rich in the polyunsaturated fatty acid linoleic acid. Linoleic acid is biosynthesized from oleic acid through activity of the oleate desaturase FATTY ACID DESATURASE 2 (FAD2), which in seeds is encoded by FAD2-1, a gene that's present in single copy in sunflowers. Defective FAD2-1 expression enriches oleic acid, yielding the high oleic (HO) acid trait, which is of great interest in oil seed crops, since HO oil bears benefits for both food and non-food applications. Chemical mutagenesis has previously been used to generate sunflower mutants with reduced FAD2-1 expression and here it was aimed to produce further genetic material in which FAD2-1 activity is lost and the HO trait is stably expressed. For this purpose, a sunflower mutant population was created using gamma irradiation and screened for fad2-1 mutants with a newly developed HPLC-based fatty-acid profiling system that's suitable for high-throughput analyses. With this approach fad2-1 knock-out mutants could be isolated, which stably hyper-accumulate oleic acid in concentrations of 85-90% of the total fatty acid pool. The genetic nature of these new sunflower lines was characterized and will facilitate marker development, for the rapid introgression of the trait into elite sunflower breeding material. [ABSTRACT FROM AUTHOR]

A large proportion of the world's disease burden is attributable to mental illnesses. Although effective interventions are available, many patients still have limited access to evidence-based treatments. Aside from access, treatment gaps, including inappropriate medication selection and monitoring, are also routinely recognised. Mental health clinical pharmacists can help address these gaps and enable patients to receive optimised pharmaceutical care, particularly appropriate medication selection and monitoring. The European Society of Clinical Pharmacy (ESCP) Special Interest Group on Mental Health was established to improve standardised service provision in mental health settings across Europe. The Special Interest Group identified significant barriers (predominantly associated with reimbursement and position within the multidisciplinary team) to effective pharmaceutical care amongst those with mental illnesses. This commentary presents recommendations to address these gaps through improved mental health clinical pharmacy service provision. [ABSTRACT FROM AUTHOR]

Soybean is a major plant protein source for both human food and animal feed, but to meet global demands as well as a trend towards regional production, soybean cultivation needs to be expanded to higher latitudes. In this study, we developed a large diversity panel consisting of 1503 early-maturing soybean lines and used genome-wide association mapping to dissect the genetic architecture underlying two crucial adaptation traits, flowering time and maturity. This revealed several known maturity loci, E1 , E2 , E3 , and E4 , and the growth habit locus Dt2 as causal candidate loci, and also a novel putative causal locus, GmFRL1 , encoding a homolog of the vernalization pathway gene FRIGIDA-like 1. In addition, the scan for quantitative trait locus (QTL)-by-environment interactions identified GmAPETALA1d as a candidate gene for a QTL with environment-dependent reversed allelic effects. The polymorphisms of these candidate genes were identified using whole-genome resequencing data of 338 soybeans, which also revealed a novel E4 variant, e4-par , carried by 11 lines, with nine of them originating from Central Europe. Collectively, our results illustrate how combinations of QTL and their interactions with the environment facilitate the photothermal adaptation of soybean to regions far beyond its center of origin. [ABSTRACT FROM AUTHOR]

This paper assesses the market effects of regulatory events associated with the implementation of a bail-in regime for failing European banks. The bail-in regime was designed to make banks efficiently resolvable in order to abolish Implicit Government Guarantees (IGGs). We use a seemingly-unrelated-regressions framework to estimate the effects on Credit Default Swap (CDS) spreads and equity returns of key events associated with the two cornerstones of the European bail-in regime, the Bank Recovery & Resolution Directive (BRRD) and the Single Resolution Mechanism Regulation (SRM-R), and other relevant events. Contrary to the regulations' objectives, we find that regulatory events associated with the implementation of BRRD and SRM-R led to tighter CDS spreads and higher equity returns over the 2009–2017 period. The pattern varies with bank heterogeneity and is particularly pronounced for global systemically important banks (G-SIBs), i.e. banks whose systemic risk profile is deemed to be of such importance that the bank's failure would trigger a wider financial crisis and threaten the global economy, suggesting that the regime does not effectively solve the systemic problem of bailout expectations in the European banking sector. [ABSTRACT FROM AUTHOR]

Background Availability of assisted PD (asPD) increases access to dialysis at home, particularly for the increasing numbers of older and frail people with advanced kidney disease. Although asPD has been widely used in some European countries for many years, it remains unavailable or poorly utilized in others. A group of leading European nephrologists have therefore formed a group to drive increased availability of asPD in Europe and in their own countries. Methods Members of the group filled in a proforma with the following headings: personal experience, country experience, who are the assistants, funding of asPD, barriers to growth, what is needed to grow and their top three priorities. Results Only 5 of the 13 countries surveyed provided publicly funded reimbursement for asPD. The use of asPD depends on overall attitudes to PD, with all respondents mentioning the need for nephrology team education and/or patient education and involvement in dialysis modality decision making. Conclusions and call to action Many people with advanced kidney disease would prefer to have their dialysis at home, yet if the frail patient chooses PD most healthcare systems cannot provide their choice. AsPD should be available in all countries in Europe and in all renal centres. The top priorities to make this happen are education of renal healthcare teams about the advantages of PD, education of and discussion with patients and their families as they approach the need for dialysis, and engagement with policymakers and healthcare providers to develop and support assistance for PD. [ABSTRACT FROM AUTHOR]

During spring 2020, the COVID-19 pandemic caused massive reductions in emissions from industry and ground and airborne transportation. To explore the resulting atmospheric composition changes, we conducted the BLUESKY campaign with two research aircraft and measured trace gases, aerosols, and cloud properties from the boundary layer to the lower stratosphere. From 16 May to 9 June 2020, we performed 20 flights in the early COVID-19 lockdown phase over Europe and the Atlantic Ocean. We found up to 50% reductions in boundary layer nitrogen dioxide concentrations in urban areas from GOME-2B satellite data, along with carbon monoxide reductions in the pollution hot spots. We measured 20%–70% reductions in total reactive nitrogen, carbon monoxide, and fine mode aerosol concentration in profiles over German cities compared to a 10-yr dataset from passenger aircraft. The total aerosol mass was significantly reduced below 5 km altitude, and the organic aerosol fraction also aloft, indicative of decreased organic precursor gas emissions. The reduced aerosol optical thickness caused a perceptible shift in sky color toward the blue part of the spectrum (hence BLUESKY) and increased shortwave radiation at the surface. We find that the 80% decline in air traffic led to substantial reductions in nitrogen oxides at cruise altitudes, in contrail cover, and in resulting radiative forcing. The light extinction and depolarization by cirrus were also reduced in regions with substantially decreased air traffic. General circulation–chemistry model simulations indicate good agreement with the measurements when applying a reduced emission scenario. The comprehensive BLUESKY dataset documents the major impact of anthropogenic emissions on the atmospheric composition. [ABSTRACT FROM AUTHOR]

More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children. [ABSTRACT FROM AUTHOR]

• All European proton therapy centres reported on their clinical RBE considerations. • For most proton centres, variable RBE is a serious concern. • All prescribe a constant RBE but actively counteract variable RBE effects in OAR. • Variable RBE is frequently considered by avoiding beams to stop inside or near OAR. • Needs: clinical studies on variable RBE effects and LET/RBE calculation tools. The relative biological effectiveness (RBE) varies along the treatment field. However, in clinical practice, a constant RBE of 1.1 is assumed, which can result in undesirable side effects. This study provides an accurate overview of current clinical practice for considering proton RBE in Europe. A survey was devised and sent to all proton therapy centres in Europe that treat patients. The online questionnaire consisted of 39 questions addressing various aspects of RBE consideration in clinical practice, including treatment planning, patient follow-up and future demands. All 25 proton therapy centres responded. All centres prescribed a constant RBE of 1.1, but also applied measures (except for one eye treatment centre) to counteract variable RBE effects such as avoiding beams stopping inside or in front of an organ at risk and putting restrictions on the minimum number and opening angle of incident beams for certain treatment sites. For the future, most centres (16) asked for more retrospective or prospective outcome studies investigating the potential effect of the effect of a variable RBE. To perform such studies, 18 centres asked for LET and RBE calculation and visualisation tools developed by treatment planning system vendors. All European proton centres are aware of RBE variability but comply with current guidelines of prescribing a constant RBE. However, they actively mitigate uncertainty and risk of side effects resulting from increased RBE by applying measures and restrictions during treatment planning. To change RBE-related clinical guidelines in the future more clinical data on RBE are explicitly demanded. [ABSTRACT FROM AUTHOR]

Background: The hepatitis B and D virus (HBV/HDV) hepatocyte entry inhibitor bulevirtide (BLV) has been available in Europe since July 2020, after the registrational trial MYR202. Real-life data on the efficacy and safety of BLV are sparse. Methods: We have analysed the course of treatment with BLV (2 mg/day) plus tenofovir disoproxil fumarate (TDF) (245 mg/day) in patients with chronic hepatitis delta (CHD). Virologic (≥2 log reduction in HDV RNA or suppression of HDV RNA below the lower limit of detection) and biochemical (normalisation of serum ALT) treatment responses after 24 weeks were defined according to the MYR202 trial. Results: Seven patients were recruited (four with liver cirrhosis Child–Pugh A). After 24 weeks, a virologic response was observed in five of seven and a biochemical response was seen in three of six patients with elevated serum ALT at baseline. Extended treatment data > 48 weeks were available in three cases: two presented with continuous virologic and biochemical responses and in one individual an HDV-RNA breakthrough was observed. Adverse effects were not recorded. Conclusions: The first real-life data of the approved dosage of 2 mg of BLV in combination with TDF confirm the safety, tolerability, and efficacy of the registrational trial MYR202 for a treatment period of 24 weeks and beyond. [ABSTRACT FROM AUTHOR]

Advanced intra-procedural imaging techniques have been integral to technical and procedural success transcatheter devices. A novel leaflet approximation therapy, the PASCAL Transcatheter Valve Repair System (Edwards Lifesciences, Irvine, CA, USA) has demonstrated high procedural success, acceptable safety, and significant clinical improvement in patients with severe mitral and tricuspid regurgitation and has CE mark approval in Europe with pivotal trials underway in the USA. This review outlines the pre-procedural imaging views and advanced transoesophageal imaging protocols both mitral and tricuspid valve device implantation. [ABSTRACT FROM AUTHOR]

Clinical data suggest that the relative biological effectiveness (RBE) in proton therapy (PT) varies with linear energy transfer (LET). However, LET calculations are neither standardized nor available in clinical routine. Here, the status of LET calculations among European PT institutions and their comparability are assessed. Eight European PT institutions used suitable treatment planning systems with their center-specific beam model to create treatment plans in a water phantom covering different field arrangements and fulfilling commonly agreed dose objectives. They employed their locally established LET simulation environments and procedures to determine the corresponding LET distributions. Dose distributions D1.1 and DRBE assuming constant and variable RBE, respectively, and LET were compared among the institutions. Inter-center variability was assessed based on dose- and LET-volume-histogram parameters. Treatment plans from six institutions fulfilled all clinical goals and were eligible for common analysis. D1.1 distributions in the target volume were comparable among PT institutions. However, corresponding LET values varied substantially between institutions for all field arrangements, primarily due to differences in LET averaging technique and considered secondary particle spectra. Consequently, DRBE using non-harmonized LET calculations increased inter-center dose variations substantially compared to D1.1 and significantly in mean dose to the target volume of perpendicular and opposing field arrangements (p < 0.05). Harmonizing LET reporting (dose-averaging, all protons, LET to water or to unit density tissue) reduced the inter-center variability in LET to the order of 10–15% within and outside the target volume for all beam arrangements. Consequentially, inter-institutional variability in DRBE decreased to that observed for D1.1. Harmonizing the reported LET among PT centers is feasible and allows for consistent multi-centric analysis and reporting of tumor control and toxicity in view of a variable RBE. It may serve as basis for harmonized variable RBE dose prescription in PT. [ABSTRACT FROM AUTHOR]

Increasing soybean yield plays a key role in meeting the high demand for protein in Europe and other countries. The aim of this study was to dissect the genetic architecture underlying seed yield, plant height, protein yield and thousand‐seed weight in early‐maturing soybean. To this end, we performed QTL mapping based on 944 RILs derived from a half‐diallel crossing design of five parents. We identified five to eight QTL for each of the four agronomic traits and some explained a considerable proportion of the genotypic variance. The three major QTL showed pleiotropic effects on two or more traits. Fine characterization revealed the maturity genes E1 and E3, and the stem growth habit gene Dt2 as likely candidates underlying these QTL. In general, the allele increasing seed yield also resulted in taller plants, which needs to be considered during selection due to an increased risk of lodging. Collectively, our results underline the strong effect of some loci like the E1 gene on a range of traits including seed yield, making them attractive targets for a marker‐assisted selection. [ABSTRACT FROM AUTHOR]

Information about the spatiotemporal variability of soil moisture is critical for many purposes, including monitoring of hydrologic extremes, irrigation scheduling, and prediction of agricultural yields. We evaluated the temporal dynamics of 18 state-of-the-art (quasi-)global near-surface soil moisture products, including six based on satellite retrievals, six based on models without satellite data assimilation (referred to hereafter as "open-loop" models), and six based on models that assimilate satellite soil moisture or brightness temperature data. Seven of the products are introduced for the first time in this study: one multi-sensor merged satellite product called MeMo (Merged soil Moisture) and six estimates from the HBV (Hydrologiska Byråns Vattenbalansavdelning) model with three precipitation inputs (ERA5, IMERG, and MSWEP) with and without assimilation of SMAPL3E satellite retrievals, respectively. As reference, we used in situ soil moisture measurements between 2015 and 2019 at 5 cm depth from 826 sensors, located primarily in the USA and Europe. The 3-hourly Pearson correlation (R) was chosen as the primary performance metric. We found that application of the Soil Wetness Index (SWI) smoothing filter resulted in improved performance for all satellite products. The best-to-worst performance ranking of the four single-sensor satellite products was SMAPL3E SWI , SMOS SWI , AMSR2 SWI , and ASCAT SWI , with the L-band-based SMAPL3E SWI (median R of 0.72) outperforming the others at 50 % of the sites. Among the two multi-sensor satellite products (MeMo and ESA-CCI SWI), MeMo performed better on average (median R of 0.72 versus 0.67), probably due to the inclusion of SMAPL3E SWI. The best-to-worst performance ranking of the six open-loop models was HBV-MSWEP, HBV-ERA5, ERA5-Land, HBV-IMERG, VIC-PGF, and GLDAS-Noah. This ranking largely reflects the quality of the precipitation forcing. HBV-MSWEP (median R of 0.78) performed best not just among the open-loop models but among all products. The calibration of HBV improved the median R by +0.12 on average compared to random parameters, highlighting the importance of model calibration. The best-to-worst performance ranking of the six models with satellite data assimilation was HBV-MSWEP+SMAPL3E, HBV-ERA5+SMAPL3E, GLEAM, SMAPL4, HBV-IMERG+SMAPL3E, and ERA5. The assimilation of SMAPL3E retrievals into HBV-IMERG improved the median R by +0.06 , suggesting that data assimilation yields significant benefits at the global scale. [ABSTRACT FROM AUTHOR]

The COVID‐19 pandemic has had an immediate and dramatic impact on dental education. The Association of Dental Education in Europe decided to carry out an investigation to assess the immediate response of European Academic Dental Institutions. An online survey was sent to both member and non‐member dental schools to investigate the impact on non‐clinical and clinical education, assessment and the well‐being/pastoral care measures implemented. The preliminary findings and discussion are presented in this paper, for the responses collected between the 25 March and 5 April 2020. The survey at this time of publication is ongoing, and detailed results can be accessed https://adee.org/covid‐19‐european‐dental‐education%E2%80%99s‐immediate‐response. [ABSTRACT FROM AUTHOR]

Digitization of medicine requires systematic handling of the increasing amount of health data to improve medical diagnosis. In this context, the integration of the versatile diagnostic information, e.g., from anamnesis, imaging, histopathology, and clinical chemistry, and its comprehensive analysis by artificial intelligence (AI)-based tools is expected to improve diagnostic precision and the therapeutic conduct. However, the complex medical environment poses a major obstacle to the translation of integrated diagnostics into clinical research and routine. There is a high need to address aspects like data privacy, data integration, interoperability standards, appropriate IT infrastructure, and education of staff. Besides this, a plethora of technical, political, and ethical challenges exists. This is complicated by the high diversity of approaches across Europe. Thus, we here provide insights into current international activities on the way to digital comprehensive diagnostics. This includes a technical view on challenges and solutions for comprehensive diagnostics in terms of data integration and analysis. Current data communications standards and common IT solutions that are in place in hospitals are reported. Furthermore, the international hospital digitalization scoring and the European funding situation were analyzed. In addition, the regional activities in radiomics and the related publication trends are discussed. Our findings show that prerequisites for comprehensive diagnostics have not yet been sufficiently established throughout Europe. The manifold activities are characterized by a heterogeneous digitization progress and they are driven by national efforts. This emphasizes the importance of clear governance, concerted investments, and cooperation at various levels in the health systems.Key Points• Europe is characterized by heterogeneity in its digitization progress with predominantly national efforts. Infrastructural prerequisites for comprehensive diagnostics are not given and not sufficiently funded throughout Europe, which is particularly true for data integration.• The clinical establishment of comprehensive diagnostics demands for a clear governance, significant investments, and cooperation at various levels in the healthcare systems.• While comprehensive diagnostics is on its way, concerted efforts should be taken in Europe to get consensus concerning interoperability and standards, security, and privacy as well as ethical and legal concerns. [ABSTRACT FROM AUTHOR]

Migratory birds complete their seasonal journeys between breeding and non‐breeding sites with a series of migratory flights that are separated by prolonged stopovers. While songbirds are the most common taxa among migratory birds, empirical data on flight and stopover behaviour along their entire migratory journeys are still rare. Here, we integrate activity and barometric pressure tracking with classical light‐level geolocation to describe migration behaviour of tawny pipits Anthus campestris breeding in central Europe. Surprisingly, tracked pipits used, on average, as many as 10 stopover sites during their six week, > 5000 km long autumn migration. This conforms to a typical hop‐type pattern of migration. In contrast to common knowledge which considers the tawny pipit as a typical diurnal migrant, our data revealed that more than two thirds of all migratory movements were carried out at night. Nocturnal departure times were highly variable within individuals and spread across the entire night while landing most often took place within the first few hours after sunrise. Consequently, there was a negative relationship between departure timing relative to sunset and flight duration. Short flights of up to 2 h were most common and median flight duration was 4.5 h. There was a hyperbolic relationship between flight duration and maximum flight altitude and flight altitudes during night were two times higher compared to daytime. The overall ratio of flight versus stopover duration during migration was on average 1:6.5. This closely matches predictions from theoretical models. We show that multi‐sensor tracking has the potential to provide unprecedented details on migratory behaviour of individual birds along their entire migratory journeys, and it also improves the precision of geographical locations derived from light‐level geolocators. [ABSTRACT FROM AUTHOR]

The popularity and the high nicotine content of the American pod e-cigarette JUUL have raised many concerns. To comply with European law, the nicotine concentration in the liquids of the European version, which has been recently released on the market, is limited to below 20 mg/mL. This limit can possibly be circumvented by technological adjustments that increase vaporization and consequently, elevate nicotine delivery. In this study, we compare vapor generation and nicotine delivery of the initial European version, a modified European version, and the original American high-nicotine variant using a machine vaping set-up. Additionally, benzoic acid and carbonyl compounds are quantified in the aerosol. Further, concentrations of nicotine, benzoic acid, propylene glycol, and glycerol, along with the density and pH value of JUUL e-liquids have been assessed. Whereas the initial European version did not compensate for the low nicotine content in the liquid, we provide evidence for an increased vaporization by the modified European version. As a consequence, nicotine delivery per puff approximates the American original. Notably, this is not associated with an increased generation of carbonyl compounds. Our data suggest a similar addictiveness of the enhanced European version and the original American product. [ABSTRACT FROM AUTHOR]

The SIU (Société Internationale d'Urologie)-ICUD (International Consultation on Urologic Diseases) working group on systemic therapy for metastatic bladder cancer has summarized the most recent findings on the aforementioned topic and came to conclusions and recommendations according to the evidence published. In Europe and the United States, treatment for metastatic UC has changed a great deal recently, mainly involving a move from chemotherapy to immune checkpoint blockers. This is particularly true in platinum-refractory disease, where supportive randomized data exist. Five checkpoint blockers have been approved in this setting by the FDA: avelumab, atezolizumab, durvalumab, nivolumab, and pembrolizumab. Nivolumab, pembrolizumab, and atezolizumab have been approved in Europe. [ABSTRACT FROM AUTHOR]

Soybean cultivation holds great potential for a sustainable agriculture in Europe, but adaptation remains a central issue. In this large mega-environment (MEV) study, 75 European cultivars from five early maturity groups (MGs 000-II) were evaluated for maturity-related traits at 22 locations in 10 countries across Europe. Clustering of the locations based on phenotypic similarity revealed six MEVs in latitudinal direction and suggested several more. Analysis of maturity identified several groups of cultivars with phenotypic similarity that are optimally adapted to the different growing regions in Europe. We identified several haplotypes for the allelic variants at the E1, E2, E3 and E4 genes, with each E haplotype comprising cultivars from different MGs. Cultivars with the same E haplotype can exhibit different flowering and maturity characteristics, suggesting that the genetic control of these traits is more complex and that adaptation involves additional genetic pathways, for example temperature requirement. Taken together, our study allowed the first unified assessment of soybean-growing regions in Europe and illustrates the strong effect of photoperiod on soybean adaptation and MEV classification, as well as the effects of the E maturity loci for soybean adaptation in Europe. [ABSTRACT FROM AUTHOR]

Forests provide countless ecological, societal, and climatological benefits. With changing climate, maintaining certain services may lead to a decrease in the quantity or quality of other services available from that source. Accordingly, our research objective is to analyze the effects of the provision of a certain ecosystem service on the economically optimized harvest schedules and how harvest schedules will be influenced by climate change. Based on financial portfolio theory, we determined, for two case study regions in Austria and Slovakia, treatment schedules based on nonlinear programming, which integrates climate-sensitive biophysical risks and risk-averting behavior of the management. In both cases, results recommend reducing the overaged stocking volume within several decades to establish new ingrowth, leading to an overall reduction of age and related risk, as well as an increase in growth. Under climate change conditions, the admixing of hardwoods towards spruce-fir-beech (Austria) or spruce-pine-beech (Slovakia) stands should be emphasized to account for the changing risk and growth conditions. Moreover, climate change scenarios either increased (Austria) or decreased (Slovakia) the economic return slightly. In both cases, the costs for providing the ecosystem service 'rock fall protection' increases under climate change. Although in the Austrian case there is no clear tendency between the management options, in the Slovakian case, a close-to-nature management option is preferred under climate change conditions. Increasing tree species richness, increasing structural diversity, replacing high-risk stands, and reducing average growing stocks are important preconditions for a successful sustainable management of European mountain forests in the long term. [ABSTRACT FROM AUTHOR]

Concentrated solar power (CSP) can be a flexible renewable resource on electric grids. Here we assess the direct and upstream socio-economic and environmental impacts of the projected deployment of CSP in China and Europe, using Input-Output Analysis. We first quantify the CSP experience curve, finding a learning rate of ∼16%, and combine this with future projections for installed capacity from China's National Development and Reform Commission and the International Energy Agency. We find employment intensities of 4.2 and 2.3 person-year/GWh in China and Europe, respectively (higher than PV and wind). The carbon emission intensity of CSP is currently higher than alternatives but this gap may narrow through learning. Carbon intensities are estimated at 129.7 and 99.8 gCO2eq/kWh in 2020 (in China and Europe, respectively) and could drop to 40.4 and 31.1 gCO2eq/kWh by 2050 given the projected expansion. We discuss the importance of including both environmental and socio-economic dimensions when assessing the impact of energy technologies and provide context for the role of CSP in the energy transition. • Environmental, economic, and social impact assessment of concentrated solar power. • Carbon intensities of 129.7 and 99.8 gCO2eq/kWh for China and Europe. • Employment intensities of 4.2 and 2.3 person-year/GWh in China and Europe. • Learning rate is calculated at ∼16%. • Future cost scenarios show high CSP potential in some regions. [ABSTRACT FROM AUTHOR]

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Abstract: Gyrodactylus teuchis is a widespread parasite of wild and farmed salmonids throughout Europe. It has been frequently confused with the notifiable pathogen G. salaris, to which it bears a striking morphological similarity. The species is frequently referred to as ‘cryptic’, and diagnoses are primarily based on molecular evidence. We provide the first comprehensive re-description of G. teuchis from a natural wild brown trout population in the Danube watershed, based on the state of the art morphometrics in addition to standard molecular markers. We demonstrate that despite the lack of uni-variate diagnostic character measurements, G. teuchis can be reliably distinguished from G. salaris using multivariate morphological approaches such as Principal Component Analysis or Canonical Variate Analysis, suggesting that automated diagnostic approaches for G. salaris can be modified to take account of potential G. teuchis in samples. This is the first record of G. teuchis from a host population unlikely to have been modified by human stocking efforts. The morphological variability observed in the samples collected from one site on 1day reflects the overall level of variation reported for European G. teuchis. We also report new sequence variants of the internal transcribed spacer (ITS-1) of the nuclear ribosomal gene cluster with evidence for intra-individual heterogeneity of ITS-1 within this population of G. teuchis. [Copyright &y& Elsevier]

In situ measurements of soil moisture are invaluable for calibrating and validating land surface models and satellite-based soil moisture retrievals. In addition, long-term time series of in situ soil moisture measurements themselves can reveal trends in the water cycle related to climate or land cover change. Nevertheless, on a worldwide basis the number of meteorological networks and stations measuring soil moisture, in particular on a continuous basis, is still limited and the data they provide lack standardization of technique and protocol. To overcome many of these limitations, the International Soil Moisture Network (ISMN; http://www.ipf.tuwien.ac.at/insitu) was initiated to serve as a centralized data hosting facility where globally available in situ soil moisture measurements from operational networks and validation campaigns are collected, harmonized, and made available to users. Data collecting networks share their soil moisture datasets with the ISMN on a voluntary and no-cost basis. Incoming soil moisture data are automatically transformed into common volumetric soil moisture units and checked for outliers and implausible values. Apart from soil water measurements from different depths, important metadata and meteorological variables (e.g., precipitation and soil temperature) are stored in the database. These will assist the user in correctly interpreting the soil moisture data. The database is queried through a graphical user interface while output of data selected for download is provided according to common standards for data and metadata. Currently (status May 2011), the ISMN contains data of 19 networks and more than 500 stations located in North America, Europe, Asia, and Australia. The time period spanned by the entire database runs from 1952 until the present, although most datasets have originated during the last decade. The database is rapidly expanding, which means that both the number of stations and the time period covered by the existing stations are still growing. Hence, it will become an increasingly important resource for validating and improving satellite-derived soil moisture products and studying climate related trends. As the ISMN is animated by the scientific community itself, we invite potential networks to enrich the collection by sharing their in situ soil moisture data. [ABSTRACT FROM AUTHOR]

Abstract: While the need for and lack of implementation of more sophisticated methods for measuring the impact of public relations efforts has been well documented in the U.S. and some other world regions, relatively little information exist about this practice in the European Union. Results from a survey of both consumers and providers of public relations in the EU shows that perceptions of effectiveness and actual use are not related for most advanced techniques of measurement and evaluation. These results demonstrate some potentially important differences between the perceptions of providers and consumers that may support practitioner observations regarding a lack of interest among clients in more accurate assessment of results from public relations activities. [Copyright &y& Elsevier]

Since 1899 ringing (or banding) remained the most important source of information about migration routes, stopover sites and wintering grounds for birds that are too small to carry satellite-based tracking systems. Despite the large quantity of migrating birds ringed in their breeding areas in Europe, the number of ring recoveries from sub-Saharan Africa is very low and therefore the whereabouts of most small bird species outside the breeding season remain a mystery. With new miniaturized light-level geolocators it is now possible to look beyond the limits of ring recovery data. Here we show for the first time year round tracks of a near passerine trans-Saharan migrant, the European Hoopoe (Upupa epops epops). Three birds wintered in the Sahel zone of Western Africa where they remained stationary for most of the time. One bird chose a south-easterly route following the Italian peninsula. Birds from the same breeding population used different migration routes and wintering sites, suggesting a low level of migratory connectivity between breeding and wintering areas. Our tracking of a near passerine bird, the European Hoopoe, with light-level geolocators opens a new chapter in the research of Palaearctic-African bird migration as this new tool revolutionizes our ability to discover migration routes, stopover sites and wintering grounds of small birds. [ABSTRACT FROM AUTHOR]

Background: No standard therapy exists for post-docetaxel castrate-resistant prostate cancer (CRPC) patients. This trial aimed to determine the safety and efficacy of pemetrexed in post-docetaxel CRPC patients. [ABSTRACT FROM PUBLISHER]

Since the attacks of 9/11, U.S. media coverage of foreign news has changed significantly. As part of a wider study, this research identifies trends in reporting Europe in the United States after 9/11. Following a summary of the current state of research, the study's methodological design is discussed. It is based on a sample of 27 qualitative semistructured in-depth interviews with foreign correspondents working for different U.S. media outlets in Europe. The interviewed correspondents describe that since 9/11, U.S. public interest in 9/11-related foreign affairs has increased while general U.S. foreign news coverage has decreased further. With the geographic news focus shifted toward the Middle East, Europe-based U.S. foreign correspondents increasingly report about Muslim communities in Europe. The article also discusses perspectives pertaining to the future development of transatlantic foreign reporting and foreign correspondents in the post-9/11 era. [ABSTRACT FROM AUTHOR]

To report the clinical phenotype and associated genotype of a European patient cohort with GUCY2D-related autosomal-dominant (AD) cone–/cone–rod dystrophy (COD/CORD), we retrospectively analyzed 25 patients (17 female, range 12–68) with GUCY2D-related AD-COD/CORD from three major academic centers in Europe and reviewed the previously published data of 148 patients (visual acuity (VA), foveal thickness, age of first symptoms, and genetic variant). Considering all the patients, the onset of first symptoms was reported at a median age of 7 years (interquartile range 5–19 years, n = 78), and mainly consisted of reduced VA, photophobia and color vision abnormality. The disease showed a high degree of inter-eye symmetry in terms of VA (n = 165, Spearman's ρ = 0.85, p < 0.0001) and foveal thickness (Spearman's ρ = 0.96, n = 38, p < 0.0001). Disease progression was assessed by plotting VA as a function of age (n = 170). A linear best-fit analysis suggested a loss of 0.17 logMAR per decade (p < 0.0001). We analyzed the largest cohort described so far (n = 173), and found that the most common mutations were p.(Arg838Cys) and p.(Arg838His). Furthermore, the majority of patients suffered severe vision loss in adulthood, highlighting a window of opportunity for potential intervention. The emerging patterns revealed by this study may aid in designing prospective natural history studies to further define endpoints for future interventional trials. [ABSTRACT FROM AUTHOR]

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In response to the increasing impact of regulation, several governments have introduced economic analysis as a way of trying to improve regulatory policy. This paper provides a comprehensive assessment of government-supported economic analysis of regulation. We find that there is growing interest in the use of economic tools, such as benefit-cost analysis; however, the quality of analysis in the U.S. and European Union frequently fails to meet widely accepted guidelines. Furthermore, the relationship between analysis and policy decisions is tenuous. To address this situation, we recommend pursuing an agenda in which economics plays a more central role in regulatory decision making. In addition, we suggest that prediction markets could help improve regulatory policy and improve measurement of the impact of regulation. [ABSTRACT FROM AUTHOR]

Aims: To develop standardised texts for assessing reading speed during repeated measurements and across languages for normal subjects and low vision patients. Methods: 10 texts were designed by linguistic experts in English, Finnish, French, and German. The texts were at the level of a sixth grade reading material (reading ages 10-12 years) and were matched for length (830 (plus or minus 2) characters) and syntactic complexity, according to the syntactic prediction locality theory of Gibson. 100 normally sighted native speaking volunteers aged 18-35 years (25 per language) read each text aloud in randomised order. The newly designed text battery was then applied to test the reading performance of 100 normally sighted native speaking volunteers aged 60-85 years (25 per language). Results: Reading speed was not significantly different with at least seven texts in all four languages. The maximum reading speed difference between texts, in the same language was 6.8% (Finnish). Average reading speeds (SD) in characters per minute are, for the young observer group: English 1234 (147), Finnish 1263 (142), French 1214 (152), German 1126 (105). The group of older readers showed statistically significant lower average reading speeds: English 951 (97), Finnish 1014 (179), French 1131 (160), German 934(117). Conclusion: The authors have developed a set of standardised, homogeneous, and comparable texts in four European languages (English, Finnish, French, German). These texts will be a valuable tool for measuring reading speed in international studies in the field of reading and low vision research. [ABSTRACT FROM AUTHOR]

Numerous sets of diagnostic criteria have sought to define chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and randomized trials and systematic reviews of treatment have been published. The objective is to prepare consensus guidelines on the definition, investigation and treatment of CIDP. Disease experts and a patient representative considered references retrieved from MEDLINE and Cochrane Systematic Reviews in May 2004 and prepared statements which were agreed in an iterative fashion. The Task Force agreed on good practice points to define clinical and electrophysiological diagnostic criteria for CIDP with or without concomitant diseases and investigations to be considered. The principal treatment recommendations were: (1) intravenous immunoglobulin (IVIg) or corticosteroids should be considered in sensory and motor CIDP (level B recommendation); (2) IVIg should be considered as the initial treatment in pure motor CIDP (Good Practice Point); (3) if IVIg and corticosteroids are ineffective plasma exchange (PE) should be considered (level A recommendation); (4) If the response is inadequate or the maintenance doses of the initial treatment are high, combination treatments or adding an immunosuppressant or immunomodulatory drug should be considered (Good Practice Point); (5) Symptomatic treatment and multidisciplinary management should be considered (Good Practice Point). [ABSTRACT FROM AUTHOR]

During the period of "existing socialism" in Europe, the views of Lukács on socialist democracy did not receive adequate study in Marxist-Leninist philosophy. The author, long associated with the Marxist-Leninist philosophical outlook, takes a fresh look at Lukács and notes that Lukács's theoretical critique of the deformations of existing socialism was a socialist criticism quite distinct from bourgeois criticism. Relevant to this critique was Lukács's recommendation for a fundamental alternative to the dualism of thinking and being. [ABSTRACT FROM AUTHOR]

Background: Numerous sets of diagnostic criteria have sought to define chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and randomized trials and systematic reviews of treatment have been published. Objectives: The aim of this guideline was to prepare consensus guidelines on the definition, investigation, and treatment of CIDP. Methods: Disease experts and a representative of patients considered references retrieved from MEDLINE and Cochrane Systematic Reviews in May 2004 and prepared statements that were agreed in an iterative fashion. Recommendations: The Task Force agreed on good practice points to define clinical and electrophysiological diagnostic criteria for CIDP with or without concomitant diseases and investigations to be considered. The principal treatment recommendations were as follows: (1) intravenous immunoglobulin (IVIg) or corticosteroids should be considered in sensory and motor CIDP (level B recommendation); (2) IVIg should be considered as the initial treatment in pure motor CIDP (good practice point); (3) if IVIg and corticosteroids are ineffective, plasma exchange should be considered (level A recommendation); (4) if the response is inadequate or the maintenance doses of the initial treatment are high, combination treatments or adding an immunosuppressant or immunomodulatory drug should be considered (good practice point); and (5) symptomatic treatment and multidisciplinary management should be considered (good practice point). [ABSTRACT FROM AUTHOR]

Objective. This study employed an ecological framework to examine the totes of multiple contributors to variations in key maternal perceptions of their own parenting. Design. Maternal socioeconomic status (SES), employment, and parenting support; child gender, language. social competence, and temperament; and maternal intelligence, personality, and parenting knowledge and style were explored in separate predictions of self-perceived competence, satisfaction, investment, and role balance in 234 European American mothers of firstborn, 20-month-old children. Results. Hierarchical regression analyses indicated highly differentiated patterns of unique predictive relations to each domain of self-perceived parenting. Nonetheless, some predictors consistently contributed to individual parenting self-perceptions, most prominently. parenting knowledge and dissonance between actual and ideal maternal and paternal parenting styles. SES, maternal employment, community support, and maternal personality also contributed to self-perceptions, as did child temperament. Conclusions. Although the potential contributors to parenting sell-perceptions may be many, prominent contributors to any one self-perception are few, and constellations of contributors differ for different parenting sell-perceptions, conclusions that articulate with the modular view of parenting. [ABSTRACT FROM AUTHOR]

Describes the ultramicrobacteria classified as actinobacteria isolated from five freshwater habitats in Europe and Asia. Characteristics of aquatic habitats from which actinobacterial strains were isolated; Interaction of the ultramicrobacteria isolated with the bacterivorous nanoflagellate ochromonas sp. strain DS; Different ecophysiological and phenotypic traits of the isolates obtained.

Background: Although as many as 10% of pancreatic cancer cases may have an inherited component, familial pancreatic cancer has not been linked to defects in any specific gene. Some studies have shown that families with germline mutations in the breast cancer susceptibility gene BRCA2 have an increased risk of breast and ovarian cancers, as well as a modestly increased risk of pancreatic cancer. To study these relationships in more detail, we examined whether BRCA2 germline mutations are associated with familial pancreatic cancer.Methods: We identified 26 European families in which at least two first-degree relatives had a histologically confirmed diagnosis of pancreatic ductal adenocarcinoma. We sequenced genomic DNA isolated from peripheral blood lymphocytes obtained from participating family members to identify germline mutations in BRCA2.Results: Three (12%, exact 95% confidence interval [CI] = 2% to 30%) families carried germline frameshift mutations in the BRCA2 gene that are predicted to result in a truncated BRCA2 protein. Two additional families harbored mutations previously designated as unclassified variants of BRCA2. Thus, 19% (exact 95% CI = 7% to 39%) of the families in our study had either a frameshift mutation or an unclassified variant of BRCA2. None of the families in our study met the criteria for familial breast or ovarian cancer.Conclusions: Our data support an important role for BRCA2 germline mutations in a subpopulation of families with familial pancreatic cancer. BRCA2 mutation analysis should be included in molecular genetic testing and counseling strategies in families with at least two first-degree relatives affected with ductal adenocarcinoma of the pancreas. [ABSTRACT FROM AUTHOR]

Background/Aim: Only a few follow up data are available for patients with hepatocellular carcinoma (HCC) in Europe and the USA. Therefore, we analysed all HCC patients admitted to our hospital between 1988 and 1999. Methods: We documented aetiology, stage (HCC: Okuda and UICC classifications, liver cirrhosis: Child-Pugh score), and diagnostic and therapeutic measures of 281 consecutive HCC patients. Survival time was calculated as a function of staging and therapy. Results.' Cirrhosis was diagnosed in all patients. Seventy-two patients underwent liver resection, 28 liver transplantation, 31 transarterial chemoembolization and 14 percutaneous ethanol injection. One hundred and thirty-six patients received no treatment. The Okuda and the Child-Pugh classification predicted a significant decrease of median survival time, whereas the UICC classification was less powerful. Conclusions: HCC occurred only in patients with liver cirrhosis. Survival time correlated with therapy (or no therapy) and with the Child-Pugh Score. In European patients the Okuda classification is superior to the UICC classification and should be compared to novel classification systems. [ABSTRACT FROM AUTHOR]

The European Union is currently revising its system of centralised authorisation for agreements between firms falling within the scope of Article 81 (1) of the EC Treaty but qualifying for exemption from the general prohibition. The proposed reform in the 1999 White Paper on Modernisation of the Rules Implementing Articles 81 and 82 of the EC Treaty involves the abolition of the notification and exemption system and its replacement by a directly applicable exception system where restrictive practices qualifying for exemption are lawful per se and subject to abuse control. This paper compares both the current notification system and the proposed system of ex-post control in a game-theoretical framework. If precommitment to an enforcement probability by the antitrust authority is not possible and a mixed equilibrium exists for both systems, the notification system is superior to the system of abuse control in terms of social welfare. [ABSTRACT FROM AUTHOR]

The author says that for decades, economists have been extolling virtues of market-based or economic-incentive approaches to environmental protection. Both environmental taxes and marketable permits are coming of age in the policy arena. Examples include the introduction of marketable permits in the United States to control acid rain, the use of charges in Europe to limit air and water pollution, and the employment of deposit-refund schemes for products ranging from beverage containers to batteries. Although some policymakers would likely claim that the singular objective of environmental regulation is to protect environmental quality, the decision problem actually faced by policymakers is far more complex, involving trade-offs among multiple objectives. Comparisons between conventional command-and-control regulation, including technology standards and performance standards, and market-based approaches, including taxes and markets in pollution rights, have repeatedly noted that conventional regulations fail to achieve environmental objectives in the least costly manner.

The article discusses the budgetary criteria of the Stability Pact for European Monetary Union (EMU). Under the pact, the deficit was not to exceed the 3% Maastricht limit even in the case of adverse economic developments and a deficit of 1% of gross domestic product (GDP) was to be aimed for over the medium term in normal conditions. The German proposal for the pact aimed to adapt the procedure under Article 104C to the demand for automatic activation of sanctions when the 3% deficit threshold is reached.

The article offers information on the European Monetary Institute's Annual Reports. The reports have three legal functions. The first is fact-finding and checking data collected before it is supplied to European Commission (EC) Member States and their central banks, and Community institutions. Second is the implementation of international control by the assessment of relevant conduct of Member States as to its conformity with Community law. The third is the registration of progress made towards attainment of the goals set forth by the EC Treaty, the Maastricht Treaty, and relevant secondary Community law.

Vegetation products based on microwave remote sensing observations, such as Vegetation Optical Depth (VOD), are increasingly used in a variety of applications. One disadvantage is the often coarse spatial resolution of tens of kilometers of products retrieved from microwave observations from spaceborne radiometers and scatterometers. This can potentially be overcome by using new high-resolution Synthetic Aperture Radar (SAR) observations from Sentinel-1. However, the sensitivity of Sentinel-1 backscatter to vegetation dynamics, or its use in radiative transfer models, such as the water cloud model, has only been tested at field to regional scale. In this study, we compared the cross-polarization ratio (CR) to vegetation dynamics as observed in microwave-based Vegetation Optical Depth from coarse-scale satellites over Europe. CR was obtained from Sentinel-1 VH and VV backscatter observations at 500 m sampling and resampled to the spatial resolution of VOD from the Advanced SCATterometer (ASCAT) on-board the Metop satellite series. Spatial patterns between median CR and ASCAT VOD correspond to each other and to vegetation patterns over Europe. Analysis of temporal correlation between CR and ASCAT VOD shows that high Pearson correlation coefficients ( R p ) are found over croplands and grasslands (median R p > 0.75). Over deciduous broadleaf forests, negative correlations are found. This is attributed to the effect of structural changes in the vegetation canopy which affect CR and ASCAT VOD in different ways. Additional analysis comparing CR to passive microwave-based VOD shows similar effects in deciduous broadleaf forests and high correlations over crop- and grasslands. Though the relationship between CR and VOD over deciduous forests is unclear, results suggest that CR is useful for monitoring vegetation dynamics over crop- and grassland and a potential path to high-resolution VOD. [ABSTRACT FROM AUTHOR]