1. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
- Author
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Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR, and Thompson JF
- Subjects
- Adult, Aged, Alleles, Asian People, Chromosomes, Human, Pair 7, Cohort Studies, Europe, Female, Genetic Markers, Homozygote, Humans, India, Linear Models, Linkage Disequilibrium, Male, Metabolic Syndrome genetics, Mexico, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Principal Component Analysis, White People, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors genetics, Genetic Variation, Genome, Human, Triglycerides blood, Triglycerides genetics
- Abstract
We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.
- Published
- 2008
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