1. Prothrombin G20210A mutation: is it associated with pre-eclampsia?
- Author
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Higgins JR, Kaiser T, Moses EK, North R, and Brennecke SP
- Subjects
- Adult, Australia epidemiology, Base Sequence, Case-Control Studies, Confidence Intervals, DNA Mutational Analysis, Eclampsia ethnology, Eclampsia genetics, Europe ethnology, Female, Gestational Age, Humans, Molecular Sequence Data, Odds Ratio, Pedigree, Polymerase Chain Reaction, Pre-Eclampsia ethnology, Pregnancy, Prevalence, Sampling Studies, Point Mutation, Pre-Eclampsia genetics, Prothrombin genetics
- Abstract
Objective: A strong independent association between the prothrombin G20210A gene mutation and pre-eclampsia has been reported in an Italian population. This result was not confirmed in a subsequent study in a Dutch population. The objective of this study was to further test the hypothesis that the prothrombin G20210A mutation is associated with pre-eclampsia/eclampsia., Methods: Seventeen eclamptics and 67 pre-eclamptics were recruited from 34 multicase Australian/New Zealand families. An additional 105 unrelated pre-eclamptic/eclamptic women and 119 parous women were recruited as controls., Results: The overall incidence for the prothrombin G20210A gene mutation in the pre-eclamptic group was 3.6% (95% CI 1.2-8.2%) which was not significantly different from the control group 2.5% (95% CI 0.5-7.2%) (p = 0.73, OR 1.44, 95% CI 0.34-6.17)., Conclusion: This study provides little evidence of a significant relationship between the prothrombin G20210A gene mutation and pre-eclampsia. Based on our results, we do not recommend testing for the prothrombin G20210A mutation in the routine investigation of women with pre-eclampsia., (Copyright 2000 S. Karger AG, Basel.)
- Published
- 2000
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