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Marine protected areas (MPAs) provide multiple conservation benefits, thus raising the question of how good and consistent they are at their roles. Here, we quantified three components, namely, diversity, biomass, and other relevant variables, in numerous protected and unprotected areas across four marine ecoregions in south-western Europe. We created a "global conservation status index" (CSI global ) as the sum of CSI diversity , CSI biomass , and CSI relevant . We then tested whether CSI and its three components varied as a function of protection and marine ecoregion. MPA efficiency, defined as the effect size of protection on CSI global , was unreliable and varied with geography. CSI biomass and CSI relevant contributed to the unreliability of MPA efficiency, while CSI diversity was reliable. CSI biomass showed the major efficiency in protected areas (60%). Biomass of threatened species was the single largest variable that contributed to MPA efficiency. Our easy-to-use approach can identify high- and low-efficient MPAs and help to clarify their actual roles., (Copyright © 2019 Elsevier Ltd. All rights reserved.)