1. Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up.
- Author
-
Elding Larsson H, Vehik K, Bell R, Dabelea D, Dolan L, Pihoker C, Knip M, Veijola R, Lindblad B, Samuelsson U, Holl R, and Haller MJ
- Subjects
- Age Factors, Age of Onset, Autoantibodies blood, Blood Glucose analysis, Child, Preschool, Data Collection methods, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 genetics, Diabetes Mellitus, Type 1 immunology, Europe epidemiology, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Incidence, Infant, Infant, Newborn, Islets of Langerhans immunology, Longitudinal Studies, Male, Population Surveillance, Prevalence, Registries statistics & numerical data, Risk Factors, Severity of Illness Index, United States epidemiology, Diabetes Mellitus, Type 1 diagnosis, Diabetic Ketoacidosis diagnosis, Diabetic Ketoacidosis epidemiology
- Abstract
Objective: Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based incidence studies and registries., Research Design and Methods: Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register)., Results: A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children <2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P < 0.0001; Swediabkids, P = 0.02; SEARCH, P < 0.0001; Finnish Register, P < 0.0001). The prevalence of DKA in TEDDY children diagnosed at <5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P < 0.0001) and the German DPV Register (32.2%) (P < 0.0001) but not compared with Swediabkids or the Finnish Register., Conclusions: Participation in the TEDDY study is associated with reduced risk of DKA at diagnosis of type 1 diabetes in young children.
- Published
- 2011
- Full Text
- View/download PDF