11 results on '"Brewster, David"'
Search Results
2. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000-2007: Results of EUROCARE-5 population-based study.
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De Angelis, Roberta, Minicozzi, Pamela, Sant, Milena, Dal Maso, Luigino, Brewster, David H., Osca-Gelis, Gemma, Visser, Otto, Maynadié, Marc, Marcos-Gragera, Rafael, Troussard, Xavier, Agius, Dominic, Roazzi, Paolo, Meneghini, Elisabetta, and Monnereau, Alain
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AGE distribution , *CANCER patients , *REPORTING of diseases , *LYMPHOMAS , *NOSOLOGY , *POPULATION geography , *SURVIVAL analysis (Biometry) , *MYELOID leukemia , *DESCRIPTIVE statistics , *HEMATOLOGIC malignancies - Abstract
Background: Significant advances in the management of patients with lymphoid and myeloid malignancies entered clinical practice in the early 2000's. The EUROCARE-5 study database provides an opportunity to assess the impact of these changes at the population level by country in Europe. We provide survival estimates for clinically relevant haematological malignancies (HM), using the International Classification of Diseases for Oncology 3, by country, gender and age in Europe. Methods: We estimated age-standardised relative survival using the complete cohort approach for 625,000 adult patients diagnosed in 2000-2007 and followed up to 2008. Survival information was provided by 89 participating cancer registries from 29 European countries. Mean survival in Europe was calculated as the population weighted average of country-specific estimates. Results: On average in Europe, 5-year relative survival was highest for Hodgkin lymphoma (81%; 40,625 cases), poorest for acute myeloid leukaemia (17%; 57,026 cases), and intermediate for non-Hodgkin lymphoma (59%; 329,204 cases), chronic myeloid leukaemia (53%; 17,713 cases) and plasma cell neoplasms (39%; 94,024 cases). Survival was generally lower in Eastern Europe and highest in Central and Northern Europe. Wider between country differences (>10%) were observed for malignancies that benefited from therapeutic advances, such as chronic myeloid leukaemia, chronic lymphocytic leukaemia, follicular lymphoma, diffuse large B-cell lymphoma and multiple myeloma. Lower differences (<10%) were observed for Hodgkin lymphoma. Conclusions: Delayed or reduced access to innovative and appropriate therapies could plausibly have contributed to the observed geographical disparities between European regions and countries. Population based survival by morphological sub-type is important for measuring outcomes of HM management. To better inform quality of care research, the collection of detailed clinical information at the population level should be prioritised. [ABSTRACT FROM AUTHOR]
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- 2015
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3. Up-to-date estimates of breast cancer survival for the years 2000–2004 in 11 European countries: The role of screening and a comparison with data from the United States
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Rosso, Stefano, Gondos, Adam, Zanetti, Roberto, Bray, Freddie, Zakelj, Maja, Zagar, Tina, Smailyte, Giedre, Ponti, Antonio, Brewster, David H., Voogd, Adri C., Crocetti, Emanuele, and Brenner, Hermann
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BREAST cancer research , *SURVIVAL analysis (Biometry) , *MEDICAL screening , *DATA analysis , *BREAST tumors , *CANCER , *RESEARCH funding , *TIME , *DISEASE incidence - Abstract
Introduction: We investigated survival in breast cancer patients by age group, focussing on those covered by screening programmes, using data from 12 European population-based cancer registries participating in the European Network for Indicators on Cancer Survival Working Group. Methods: We calculated period estimates of 5-year relative survival for 2000–2004 and examined the change in survival estimates for four age groups between 1990–1994 and 2000–2004. Trends in age specific incidence, survival and mortality were additionally compared to those in the United States based on results from the Surveillance Epidemiology and End Results (SEER) programme. Results: Breast cancer survival uniformly increased particularly in areas with lower breast cancer survival for patients diagnosed in 1990–1994. With the exception of Geneva, Scotland and Estonia, the rise in survival was always larger among the younger age groups than in the 70+ age group and the age-gradient widened over time. The 5-year relative survival of patients aged 70 and above in the European registries was at least 7 percentage points lower than the 5-year relative survival of patients in the same age group in the US in 2000–2004. During the study period, incidence increased in all age groups and populations with a few exceptions, an observation paralleled by declining mortality. Conclusions: Results showed that some of the geographical differences in overall survival are even larger when considering age groups, in particular between Western and Eastern European countries. Furthermore, some of the differences in survival within the Northern and Western European areas could be due to variations in the implementation of screening programmes rather than economic inequalities. [Copyright &y& Elsevier]
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- 2010
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4. Survival of adults with cancers of bone or soft tissue in Europe-Report from the EUROCARE-5 study.
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Stiller CA, Botta L, Brewster DH, Ho VKY, Frezza AM, Whelan J, Casali PG, Trama A, and Gatta G
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- Adolescent, Adult, Aged, Databases, Factual, Europe, Female, Humans, Male, Middle Aged, Prognosis, Survival Rate, Young Adult, Bone Neoplasms mortality, Registries statistics & numerical data, Soft Tissue Neoplasms mortality
- Abstract
Background: Five-year relative survival (RS) of adults with bone and soft-tissue cancers in Europe was still <60% by 1995-1999. There was large geographical survival variability, mainly for bone tumours, and survival decreased with increasing age at diagnosis., Methods: Data from 87 population-based cancer registries in 29 countries, extracted from the EUROCARE-5 database, were used to provide updated estimates of survival and describe trends in survival of adults with cancers of these sites across Europe. We calculated 5-year RS for patients diagnosed in 2000-2007. We estimated 5-year RS by the period approach to assess changes in survival between 1999-2001, 2002-2004 and 2005-2007, and provide reliable predictions for recently diagnosed patients., Results: Five-year RS was 60% for adults diagnosed with soft-tissue cancer in 2000-2007 and 53% for those with bone cancer. RS declined with increasing age at diagnosis, especially for bone cancer. Survival from bone cancer varied widely between European regions, from 63 to 62% in Northern and Central Europe to 39% in Eastern Europe. Inter-regional variation was much less for soft-tissue cancer. For both site groupings, there was little evidence of change in five-year RS up to 2002-2004, followed by increases of 3-4% during 2005-2007., Conclusions: Outcomes for adults with bone and soft-tissue cancer in Europe began to improve around 2005; new therapeutic developments are expected to result in further progress. Survival improvements already achieved must be brought more fully to elderly patients and those in Eastern Europe. European Reference Networks on rare cancers will have a vital role in future progress., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
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- 2018
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5. Population-based estimates of the occurrence of multiple vs first primary basal cell carcinomas in 4 European regions.
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de Vries E, Micallef R, Brewster DH, Gibbs JH, Flohil SC, Saksela O, Sankila R, Forrest AD, Trakatelli M, Coebergh JW, and Proby CM
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- Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell diagnosis, Carcinoma, Basal Cell pathology, Cross-Sectional Studies, Europe, Female, Humans, Incidence, Male, Middle Aged, Neoplasms, Multiple Primary diagnosis, Neoplasms, Multiple Primary pathology, Registries, Sex Factors, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Carcinoma, Basal Cell epidemiology, Cross-Cultural Comparison, Neoplasms, Multiple Primary epidemiology, Skin Neoplasms epidemiology
- Abstract
Objective: To estimate the population-based incidence of first and multiple basal cell carcinomas (BCCs) throughout Europe., Design: The registry practices of 4 population-based cancer registries that routinely register BCC incidence were evaluated for inclusion of first and subsequent histologically confirmed BCCs. Where multiple BCCs were not routinely registered, comparisons with hospital databases were made., Data Sources: Cancer registry databases from Finland, Malta, the Netherlands (Eindhoven), and Scotland were inspected for registry of first and multiple BCCs in recent years. Cross-checks with hospital and pathology databases were made to check for completeness., Results: Age-standardized first BCC incidence rates varied between 77 (Malta) and 158 (Eindhoven) per 100 000 person-years. Generally, rates were higher in males than in females, and incidences increased steeply with increasing age. There were approximately 30% more patients with a BCC and 40% to 100% more BCC tumors diagnosed in a given calendar year than were routinely reported for patients with a first primary BCC. The difference between the number of first primary BCCs and the total number of BCCs in a calendar year was generally slightly higher for males than for females and increased substantially with increasing age., Conclusion: Currently, routinely reported first BCC incidence rates of the included countries should be multiplied by a factor of 1.3 for an estimate of total number of patients diagnosed as having a BCC in a given year.
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- 2012
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6. Clinical relevance of conditional survival of cancer patients in europe: age-specific analyses of 13 cancers.
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Janssen-Heijnen ML, Gondos A, Bray F, Hakulinen T, Brewster DH, Brenner H, and Coebergh JW
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- Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Europe epidemiology, Female, Humans, Male, Middle Aged, Prognosis, Survival Analysis, Young Adult, Neoplasms mortality
- Abstract
Purpose: When cancer survivors wish to receive accurate information on their current prognosis during follow-up, conditional 5-year relative survival may be most suitable. We have estimated conditional 5-year relative survival for 13 cancers using a large European database-European Network for Indicators on Cancer (EUNICE)-of 10 dedicated long-standing cancer registries across Europe., Patients and Methods: Patients age 15 years and older diagnosed between 1985 and 2004 were included. Conditional 5-year relative survival for each age group was computed for every additional year survived up to 10 years. Period analysis with follow-up period 2000 to 2004 was used., Results: All patients with cutaneous melanoma or colorectal, endometrial, or testis cancer and younger patients with stomach, glottis, cervix, ovary, or thyroid cancer or non-Hodgkin's lymphoma exhibited hardly any excess mortality (conditional 5-year relative survival > 95%) given that they were alive at a defined time point within 10 years of initial diagnosis. However, patients with supraglottis, lung, breast, and kidney cancer, as well as older patients with most cancers exhibited substantial excess mortality (conditional 5-year relative survival < 90%). Initial differences in relative survival at diagnosis between age groups largely disappeared with time since initial diagnosis for melanoma, or stomach, colorectal, corpus uteri, or testicular cancer but persisted for patients diagnosed with other tumors. Differences between stage groups became smaller over time or disappeared., Conclusion: Conditional relative survival shows clinically relevant variations according to time since diagnosis, type of cancer, and age, and can help serve as a guide for cancer survivors in planning for their future and for doctors in planning schedules for surveillance.
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- 2010
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7. Model-based projections for deriving up-to-date cancer survival estimates: an international evaluation.
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Gondos A, Holleczek B, Janssen-Heijnen M, Brewster DH, Bray F, Rosso S, Hakulinen T, and Brenner H
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- Cohort Studies, Europe epidemiology, Humans, International Agencies, Prognosis, Registries, Risk Factors, Survival Rate, Time Factors, Models, Statistical, Neoplasms mortality
- Abstract
Model-based projections were shown to be useful for deriving most up-to-date population-based cancer survival estimates. However, the performance of these projections, which can be derived by various approaches, has only been evaluated in very few cancer patient populations. Using incidence and follow-up data for 22 common cancers from 9 long-standing population-based cancer registries from diverse parts of Europe, we compared the performance of model-based period and cohort analysis for predicting 5-year relative survival of patients diagnosed in 1996-2000 against standard survival analysis approaches (cohort, complete and period analysis). Overall, model-based predictions provided a best estimate of the later observed actual survival in 135 of 198 occasions, compared to 25, 18 and 33 occasions for cohort, complete and period analysis, respectively. Projections based on cohort and period type modeling performed essentially equally well on average, and their performance was better for more common cancers, in registries with larger population bases, and for cancers subjected to continuous clinical progress and/or ongoing screening efforts. Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments.
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- 2009
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8. Second primary cancers in patients with nasopharyngeal carcinoma: a pooled analysis of 13 cancer registries.
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Scélo G, Boffetta P, Corbex M, Chia KS, Hemminki K, Friis S, Pukkala E, Weiderpass E, McBride ML, Tracey E, Brewster DH, Pompe-Kirn V, Kliewer EV, Tonita JM, Martos C, Jonasson JG, and Brennan P
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- Adult, Australia epidemiology, Canada epidemiology, Europe epidemiology, Female, Humans, Incidence, Male, Middle Aged, Registries, Risk Factors, Singapore epidemiology, Nasopharyngeal Neoplasms epidemiology, Neoplasms, Second Primary epidemiology
- Abstract
Objective: To study the risk of second primary cancers in nasopharyngeal carcinoma (NPC) patients and the risk of NPC as second primary cancer., Methods: We used data from the cancer registries from Singapore and from 12 low-incidence areas, including a total of 8,947 first occurring NPC cases, and 167 second occurring cases. We calculated standardized incidence ratios (SIRs) by comparing the second cancer incidence in NPC patients to the first primary cancer incidence in non-cancer population. We also calculated SIRs of second NPC after other primaries., Results: In Singapore, the risk of cancers of the lung (SIR=0.42), stomach (SIR=0.41), and colon (SIR=0.23) was significantly decreased after NPC, whereas that of cancer of the tongue (SIR=11.1) was significantly increased. In Australia, Canada, and Europe, the risk of non-Hodgkin's lymphoma (NHL) (SIR=3.06), tongue cancer (SIR=5.29), brain cancer (SIR=3.89), myeloid leukemia (SIR=3.85), and non-melanoma skin cancer (NMSC) (SIR=3.47) was significantly increased after NPC. Incidences of second occurring NPCs following various primary cancers were not significantly altered compared to the incidence of first occurring NPCs., Conclusions: Immune suppression (NHL, NMSC), shared genetic factors (lung cancer, NHL, myeloid leukemia), and shared environmental risk factors (tongue and brain cancers) might explain the associations. Except for NHL, there was no evidence of association with other Epstein-Barr virus-related cancers.
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- 2007
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9. Second malignancies among survivors of germ-cell testicular cancer: a pooled analysis between 13 cancer registries.
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Richiardi L, Scélo G, Boffetta P, Hemminki K, Pukkala E, Olsen JH, Weiderpass E, Tracey E, Brewster DH, McBride ML, Kliewer EV, Tonita JM, Pompe-Kirn V, Kee-Seng C, Jonasson JG, Martos C, and Brennan P
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- Adult, Australia epidemiology, Canada epidemiology, Europe epidemiology, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Neoplasms, Germ Cell and Embryonal complications, Neoplasms, Second Primary etiology, Risk Factors, Singapore epidemiology, Survivors statistics & numerical data, Testicular Neoplasms complications, Neoplasms, Germ Cell and Embryonal epidemiology, Neoplasms, Second Primary epidemiology, Registries statistics & numerical data, Testicular Neoplasms epidemiology
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We investigated the risk of second malignancies among 29,511 survivors of germ-cell testicular cancer recorded in 13 cancer registries. Standardized incidence ratios (SIRs) were estimated comparing the observed numbers of second malignancies with the expected numbers obtained from sex-, age-, period- and population-specific incidence rates. Seminomas and nonseminomas, the 2 main histological groups of testicular cancer, were analyzed separately. During a median follow-up period of 8.3 years (0-35 years), we observed 1,811 second tumors, with a corresponding SIR of 1.65 (95% confidence interval (CI): 1.57-1.73). Statistically significant increased risks were found for fifteen cancer types, including SIRs of 2.0 or higher for cancers of the stomach, gallbladder and bile ducts, pancreas, bladder, kidney, thyroid, and for soft-tissue sarcoma, nonmelanoma skin cancer and myeloid leukemia. The SIR for myeloid leukemia was 2.39 (95% CI: 1.41-3.77) after seminomas, and 6.77 (95% CI: 4.14-10.5) after nonseminomas. It increased to 37.9 (95% CI: 18.9-67.8; based on 11 observed cases of leukemia) among nonseminoma patients diagnosed since 1990. SIRs for most solid cancers increased with follow-up duration, whereas they did not change with year of testicular cancer diagnosis. Among subjects diagnosed before 1980, 20 year survivors of seminoma had a cumulative risk of solid cancer of 9.6% (95% CI: 8.7-10.5%) vs. 6.5% expected, whereas 20 years survivors of nonseminoma had a risk of 5.0% (95% CI: 4.2-6.0%) vs. 3.1% expected. In conclusion, survivors of testicular cancers have an increased risk of several second primaries, where the effect of the treatment seems to play a major role.
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- 2007
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10. Methodology for lognormal modelling of malignant pleural mesothelioma survival time distributions: a study of 5580 case histories from Europe and USA.
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Mould RF, Lahanas M, Asselain B, Brewster D, Burgers SA, Damhuis RA, De Rycke Y, Gennaro V, and Szeszenia-Dabrowska N
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- Adult, Aged, Aged, 80 and over, Europe, Female, Humans, Male, Middle Aged, Models, Statistical, Models, Theoretical, Reference Values, Time Factors, United States, Mesothelioma epidemiology, Mesothelioma mortality, Pleural Neoplasms epidemiology, Pleural Neoplasms mortality, Statistics as Topic methods
- Abstract
A truncated left-censored and right-censored lognormal model has been validated for representing pleural mesothelioma survival times in the range 5-200 weeks for data subsets grouped by age for males, 40-49, 50-59, 60-69, 70-79 and 80+ years and for all ages combined for females. The cases available for study were from Europe and USA and totalled 5580. This is larger than any other pleural mesothelioma cohort accrued for study. The methodology describes the computation of reference baseline probabilities, 5-200 weeks, which can be used in clinical trials to assess results of future promising treatment methods. This study is an extension of previous lognormal modelling by Mould et al (2002 Phys. Med. Biol. 47 3893-924) to predict long-term cancer survival from short-term data where the proportion cured is denoted by C and the uncured proportion, which can be represented by a lognormal, by (1 - C). Pleural mesothelioma is a special case when C = 0.
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- 2004
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11. Pleural mesothelioma incidence in Europe: evidence of some deceleration in the increasing trends.
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Montanaro F, Bray F, Gennaro V, Merler E, Tyczynski JE, Parkin DM, Strnad M, Jechov'a M, Storm HH, Aareleid T, Hakulinen T, Velten M, Lef'evre H, Danzon A, Buemi A, Daur'es JP, Ménégoz F, Raverdy N, Sauvage M, Ziegler H, Comber H, Paci E, Vercelli M, De Lisi V, Tumino R, Zanetti R, Berrino F, Stanta G, Langmark F, Rachtan J, Mezyk R, Blaszczyk J, Ivan P, Primic-Zakelj M, Martínez AC, Izarzugaza I, Borràs J, Garcia CM, Garau I, Sánchez NC, Aicua A, Barlow L, Torhorst J, Bouchardy C, Levi F, Fisch T, Probst N, Visser O, Quinn M, Gavin A, Brewster D, and Mikov M
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- Asbestos, Environmental Exposure adverse effects, Europe epidemiology, Forecasting, Humans, Incidence, Linear Models, Mesothelioma etiology, Occupational Exposure adverse effects, Pleural Neoplasms etiology, Risk Factors, Mesothelioma epidemiology, Pleural Neoplasms epidemiology
- Abstract
Objective: To summarize the geographical and temporal variations in incidence of pleural mesothelioma in Europe, using the extensive data available from European general cancer registries, and consider these in light of recent trends in asbestos extraction, use and import in European countries., Material and Methods: The data were extracted from the European Cancer Incidence and Mortality database (EUROCIM). The inclusion criteria was acceptance in Volume VII of Cancer Incidence in Five Continents. Truncated age-standardized rates per 100,000 for the ages 40-74 were used to summarise recent geographical variations. Standardized rate ratios and 95% confidence intervals for the periods 1986-1990 and 1991-1995 were compared to assess geographical variations in risk. To investigate changes in the magnitude of most recent trends, regression models fitted to the latest available 10-year period (1988-1997) were compared with trends in the previous decade. Fitted rates in younger (40-64) and older adults (65-74) in the most recent period were also compared., Results: There was a great deal of geographical variation in the risk of mesothelioma, annual rates ranging from around 8 per 100,000 in Scotland, England and The Netherlands, to lower than 1 per 100,000 in Spain (0.96), Estonia (0.85), Poland (0.85) and Yugoslavia, Vojvodina (0.56) among men. The rank of the rates for women was similar to that observed for men, although rates were considerably lower. Between 1978 and 1987, rates in men significantly increased in all countries (excepting Denmark). In the following 10 years, there was a deceleration in trend, and a significant increase was detectable only in England and France. In addition, the magnitude of recent trends in younger men was generally lower than those estimated for older men, in both national and regional cancer registry settings., Conclusions: While mesothelioma incidence rates are still rising in Europe, a deceleration has started in some countries. A decrease may begin in the next few years in certain European populations considering the deceleration of observed trends in mesothelioma and asbestos exposure, as well as the recent ban on its use.
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- 2003
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