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OBJECTIVE: To probe into the characteristics of drug-related problems ( DRP ) in postoperative analgesia treatment of orthopaedic patients, so as to provide basis for pharmacists to intervene postoperative analgesia treatment and promote the rational use of analgesics. METHODS: Medical orders of postoperative patients in orthopaedics of the hospital from Apr. to Jun. 2021 were collected. Retrospective review of postoperative analgesic drugs was carried out by pre-prescription review system combined with manual review. DRP were summarized and analyzed by using the Pharmaceutical Care Network Europe (PCNE) classification system. RESULTS: A total of 272 patients with orthopaedic surgery were enrolled, of which 186 DRP were found in 124 patients (45. 59%). The main problem types of DRP were possible adverse drug events (90 cases, 48. 39%) and poor treatment effect (76 cases, 40. 86%). The main causes of DRP were interaction (35 cases, 18. 82%), long course of treatment ( 35 cases, 18. 82%), repeated drug use ( 28 cases, 15. 05%) and improper drug selection ( 27 cases, 14. 52%). CONCLUSIONS: There are still many DRP in postoperative analgesia treatment of orthopaedic patients. Pharmacists can effectively find problems and analyze causes by using PCNE classification system, which provides basis for standardized clinical rational drug use, and helps to improve postoperative pain and accelerate postoperative recovery. [ABSTRACT FROM AUTHOR]