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The study investigated the current knowledge and practice of female sex workers on HIV/ADIS risk reduction options in woldia Town, Ethiopia. The study employed descriptive research design. The quantitative survey involved 140 female sex workers were selected by using simple random sampling techniques. Ethical approval was taken that adopted from EBSS (2005) questionnaire was used for data collection. Frequency, percentage and binary logistic regression were used to analyse the data. The finding of the study shows that looking for a job, disagreement in the family, death of parents, peer pressure and attracted by town life were indicated as a major pulling and pushing factors for sex worker engagement. Majority of respondents have aware about of HIV/ADIS and practices HIV/ADIS risk reduction options. Moreover, age, alcohol use, difficulty to negotiate with clients to use condom and disapproval of clients to use condom were significantly predictors of consistent condom uses of FCSWs. Current study recommended that life skills training and existing strategies that enable sex workers to develop skills that help them resist the pressures that come from their clients and to help to support themselves needs to be part of the intervention programs. [ABSTRACT FROM AUTHOR]