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Tumors of prostate are common diseases that afflict the aging male population and second leading of death by prostate cancer Prostatic tumor can be classified into two types' benign prostatic hyperplasia (BPH), and prostatic cancer (PCa). The aim of this study is to verify the levels of alkaline phosphatase(ALP), acid phosphatase(ACP) and prostatic acid phospatase (PAP) in BPH and PCa patients. This study was carried out during the period from January to December 2009. One hundred two patients complaining from prostatic tumors and disorder in urination, their ages matches (54-85) year admitted to Al-Rezgari general hospital in Erbil. Clinical investigation for all patients done by specialist doctors for differentiate between BPH and PCa patients. Five milliliter of blood was drawn from each patients in addition to twenty healthy male as control group measurement of ALP, ACP and PAP enzymes. Among 102 patients the number and percentage of BPH patients were 74 (73%), while the number and percentage of PCa patients were 28(27%). It was observed that 22(79%) of PCa patients have localized PCa, while 6(21%) of them have metastatic PCa and the mean levels of ALP. ACP and PAP were highly significantly increased in metastatic PCa, while, in localized PCa patients only the mean levels of ACP and PAP were highly significantly increased. In BPH patients only the mean level of PAP was highly significantly increased. This study showed that the mean levels of ALP, ACP and the PAP were highly significantly increased in metastatic PCa patients, while in localized PCa only the mean levels of ACP and PAP were highly significantly increased. In BPH patients only the mean level of PA was highly significantly increased. [ABSTRACT FROM AUTHOR]