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Interplanetary coronal mass ejections (ICMEs) propagate into the outer heliosphere, where they can have a significant effect on the structure, evolution, and morphology of the solar wind, particularly during times of high solar activity. They are known to play an important role in cosmic ray modulation and the acceleration of energetic particles. ICMEs are also believed to be associated with the large global transient events that swept through the heliosphere during the declining phases of solar cycles 21 and 22. But until recently, little was known about the actual behavior of ICMEs at large heliographic latitudes and large distances from the Sun. Over the past decade, the Ulysses spacecraft has provided in situ observations of ICMEs at moderate heliographic distances over a broad range of heliographic latitudes. More recently, observations of alpha particle enhancements, proton temperature depressions, and magnetic clouds at the Voyager and Pioneer spacecraft have begun to provide comparable information regarding the behavior of ICMEs at extremely large heliocentric distances. At the same time, advances in modeling have provided new insights into the dynamics and evolution of ICMEs and their effects on cosmic rays and energetic particles. [ABSTRACT FROM AUTHOR]