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The article discusses research on how emphysematous pyelonephritis can lead to end-stage renal failure. It references a study by John A. Sayer of the Institute of Human Genetics of Newcastle University in Newcastle Upon Tyne, published in the February 14, 2008 issue of "NDT Plus." The researchers studied a 63-year-old woman, whose health deteriorated developing respiratory failure and anuric kidney injury. They found that managing this condition requires various methods like nephrectomy.