1. Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study.
- Author
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Tseng JH and Tseng MY
- Subjects
- Adolescent, Adult, Age Distribution, England epidemiology, Female, Glioma diagnosis, Humans, Male, Middle Aged, Prognosis, Registries, Sex Distribution, Spinal Neoplasms diagnosis, Survival Analysis, Survival Rate, Wales epidemiology, Glioma mortality, Spinal Neoplasms mortality
- Abstract
Background: Primary spinal gliomas are rare. Because data from the Cancer Registry of England and Wales covered larger numbers of patients and longer durations of follow-up, our objective was to define prognostic factors for survival at a national population level., Methods: From 1971 to 1995, data on 459 adult patients (age, >15 years) with primary spinal cancer from the Cancer Registry of England and Wales were analyzed. Median survival and CSRs with respect to 7 variables (age, sex, morphology, WHO grade, socioeconomic status, geographic region, and period of diagnosis) were calculated using the Kaplan-Meier method. Cox regression was performed for estimating HRs for death., Results: The median survival and the 1-, 5-, and 10-year CSRs for the population were 10.2 years, 78.7%, 59.7%, and 50.5%, respectively. Univariate analysis revealed that age at diagnosis, morphology, WHO grade, and period of diagnosis affected the CSR. Multivariate analysis demonstrated 3 factors influencing survival: older age (ie, >60 years; HR = 2.67; P < .001), non-ependymomas (HR = 3.51; P < .001), and high-grade tumors (HR = 3.01; P < .001). The improved survival in recent periods was associated with an increased number of diagnosed ependymomas., Conclusion: This study identifies old age, non-ependymomas, and high-grade tumors as negative prognostic factors for patient survival. The results from this population-based study are very helpful for comparison with those of other hospital-based studies and for public health purposes.
- Published
- 2007
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