1. Cost-effectiveness of superabsorbent wound dressing versus standard of care in patients with moderate-to-highly exuding leg ulcers.
- Author
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Veličković, Vladica M., Chadwick, Paul, Rippon, Mark G., Ilić, Ivana, McGlone, Emma Rose, Gebreslassie, Mihretab, Csernus, Mariann, Streit, Iris, Bordeanu, Adriana, Kaspar, Daniela, Linder, Jörg, and Smola, Hans
- Subjects
COMPARATIVE studies ,COMPUTER simulation ,COST effectiveness ,EXUDATES & transudates ,LEG ulcers ,NATIONAL health services ,QUALITY of life ,STATISTICAL sampling ,SURGICAL dressings ,WOUND healing ,WOUND care ,TREATMENT effectiveness ,QUALITY-adjusted life years ,DATA analysis software ,STATISTICAL models ,DESCRIPTIVE statistics - Abstract
Objective: To determine the cost-effectiveness/utility of a superabsorbent wound dressing (Zetuvit Plus Silicone) versus the current standard of care (SoC) dressings, from the NHS perspective in England, in patients with moderate-to-high exudating leg ulcers. Method: A model-based economic evaluation was conducted to analyse the cost-effectiveness/utility of a new intervention. We used a microsimulation state-transition model with a time horizon of six months and a cycle length of one week. The model uses a combination of incidence base and risk prediction approach to inform transition probabilities. All clinical efficiency, health-related quality of life (HRQoL), cost and resource use inputs were informed by conducting a systematic review of UK specific literature. Results: Treatment with the superabsorbent dressing leads to a total expected cost per patient for a six month period of £2887, associated with 15.933 expected quality adjusted life weeks and 10.9% healing rate. When treated with SoC, the total expected cost per patient for a six month period is £3109, 15.852 expected quality adjusted life weeks and 8% healing rate. Therefore, the superabsorbent dressing leads to an increase in quality-adjusted life weeks, an increase in healing rate by 2.9% and a cost-saving of £222 per single average patient over six months. Results of several scenario analyses, one-way deterministic sensitivity analysis, and probabilistic sensitivity analysis confirmed the robustness of base-case results. The probabilistic analysis confirmed that, in any combination of variable values, the superabsorbent dressing leads to cost saving results. Conclusion: According to the model prediction, the superabsorbent dressing leads to an increase in health benefits and a decrease in associated costs of treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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