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Abstract: Asymmetry in the tide (unequal ebb and flood duration) is a dominant factor in causing residual sediment transport and morphological changes in estuaries. The evolution of estuarine morphology is a process of dynamic equilibrium in the short-term, while these features are ephemeral in the long-term. In this study we investigate the spatial distribution of tidal distortion and asymmetry in the Dee estuary, UK, by 3-dimensional numerical modelling methods. High resolution LIDAR surveys are used to underpin and explain our numerical modelling results in terms of basin hypsometry and areas of recent erosion and deposition. Harmonic analysis of the numerical modelling results showed that the shallower intertidal areas (sand and mud banks) were the most tidally asymmetric, showing flood dominance. The main navigation channels showed some ebb dominance but the tides here were relatively undistorted. This overall flood dominance is likely to induce net sediment import to the Dee, which explains known historical morphological changes (large scale accretion over the last two centuries) and also recent morphological changes as seen from the LIDAR surveys (which show predominantly net accretion between 2003 and 2006). Hypsometrical analysis suggests the Dee may be approaching equilibrium, and that the flood dominance and sedimentation rate may therefore decrease in the future. In an infilling estuary, an increase in the area and elevation of tidal flats can eventually shift an estuary towards ebb dominance, as shown by previous research and by ‘idealised estuary’ modelling results presented in this study. The large tidal amplitude to hydraulic depth ratio of the Dee, however, suggests that the tidal flats would have to be very extensive indeed for this to occur. [Copyright &y& Elsevier]

The article examines a clause of the Westminster Confession of Faith found in Section 5 of Chapter 28, the chapter devoted to the sacrament of baptism. The clause claims that it is a great sin to condemn or neglect the ordinance of baptism. It analyzes the reason of the Westminster Assembly in England for developing the statement. It mentions a statement concerning infant baptism that was included in the chapter.

Objectives: To determine if breast cancer risk in women with SLE is modified by a history of exposure to hormone replacement therapy (HRT) or oral contraceptives (OC), after adjusting for other risk factors., Methods: Data were pooled from SLE cohorts at three centres. For each female cohort member (n = 871), the probability of developing breast cancer was estimated from factors (age, parity, age at first live birth, age of menarche, personal history of benign breast disease, family history) in the Gail model, an established tool for predicting breast cancer risk. From these probabilities, the expected number of breast cancers for the cohort was estimated. Actual occurrence of cases was determined by linkage with regional cancer registries. Standardized incidence ratios (SIRs; ratio of cancers observed to expected) were calculated, with subgroup analyses according to HRT and OC exposure., Results: In the cohort, 15 breast cancers occurred vs 7.2 predicted [SIR 2.1, 95% confidence interval (CI) 1.1, 3.5]. When controlling for Gail model risk factors, estimates were similar for women never exposed to HRT vs those exposed to HRT. Adjusted SIR estimates appeared similar also for women exposed or not exposed to OC., Conclusions: Although not definitive, the data suggest that the breast cancer experience in this sample is not completely explained by factors such as reproductive and family history, or by exogenous hormonal exposures. Other determinants, including medication exposures or genetic factors (possibly related to oestrogen receptors or metabolism) may be important. Variations in these factors might explain why an elevated risk of breast cancer has not been apparent in all SLE populations.