1. Risk of UTI in kidney stone formers: a matched-cohort study over a median follow-up of 19 years.
- Author
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Brain E, Geraghty RM, Cook P, Roderick P, and Somani B
- Subjects
- Electronic Health Records statistics & numerical data, England epidemiology, Female, Humans, International Classification of Diseases, Male, Middle Aged, Retrospective Studies, Risk Assessment methods, Risk Assessment statistics & numerical data, Risk Factors, Kidney Calculi complications, Kidney Calculi diagnosis, Kidney Calculi epidemiology, Urinary Tract Infections diagnosis, Urinary Tract Infections epidemiology, Urinary Tract Infections etiology, Urinary Tract Infections therapy
- Abstract
Purpose: To describe risk of UTI in Stone formers comparing to non-stone formers., Methods: Retrospective cohort study using electronic records for patients across southern England. Stone formers referred to a tertiary referral centre in Southern England, comparator patients were age and sex matched with 3:1 ratio from same database. Those with no documentation were excluded. UTI defined using ICD-10 codes. Risk of UTI presented as hazard ratio with 95% confidence interval, generated using cox regression. Sample size calculated using 80% power and significance set at 0.05., Results: Eight hundred and nineteen stone formers were included after 1000 records were screened for inclusion, with 2477 age and sex matched non-stone formers extracted from the same database. Sample size was calculated at 287 per group. Stone formers were at significantly increased risk of developing a UTI (HR 5.67; 95% CI 4.52-7.18, p < 0.001). Median follow-up was 19 years (IQR: 15-22)., Conclusions: Kidney stone formers are at increased risk of developing urinary tract infections., (© 2021. The Author(s).)
- Published
- 2021
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