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Background: Mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). We evaluated the stability of PD-MCI over time to determine its clinical utility as a marker of disease.Methods: 212 newly diagnosed participants with PD were recruited into a longitudinal study and reassessed after 18 and 36 months. Participants completed a range of clinical and neuropsychological assessments. PD-MCI was classified using Movement Disorders Society Task Force level I (Montreal Cognitive Assessment <26) and level II (using cut-offs of 1, 1.5 and 2SD) criteria.Results: After 36 months, 75% of participants returned; 8% of patients had developed a dementia all of which were previously PD-MCI. Applying level I criteria, 70% were cognitively stable, 19% cognitively declined and 11% improved over 36 months. Applying level II criteria (1, 1.5 and 2SD), 25% were cognitively stable, 41% cognitively declined, 15% improved and 19% fluctuated over 36 months. 18% of participants reverted to normal cognition from PD-MCI.Discussion: Cognitive impairment in PD is complex, with some individuals' function fluctuating over time and some reverting to normal cognition. PD-MCI level I criteria may have greater clinical convenience, but more comprehensive level II criteria with 2SD cut-offs may offer greater diagnostic certainty. [ABSTRACT FROM AUTHOR]

Objectives: To describe our preliminary experience in establishing an MRI suite capable to deliver targeted prostate biopsy and cryoablation., Methods: This article includes a description of the necessary infrastructure alterations, scanning sequence suggestions, anaesthetic advice, and practical procedural considerations. We aim to examine the anticipated issues most UK centres would encounter and offer our experience in overcoming them. During this process we will also explore some of the technical aspects of MRI-guided prostate biopsy and cryoablation., Results: The clinical indication, treatment rationale, intervention strategy, and initial clinical outcomes are described for our first series of patients., Conclusion: MRI-guided prostate intervention provides many theoretical advantages over traditional TRUS guidance. This article demonstrates some of the complexities encountered in establishing this technique in a UK centre, and the proposed solutions., Advances in Knowledge: This article gives an account of establishing the first MRI intervention suite in the UK. It demonstrates some of the logistical considerations, and offers the unit's early experience.