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This study describes the basic epidemiological features of snakebites in El Salvador for the period 2014–2019 on the basis of data provided by the national system of information on morbidity and mortality (Sistema de Morbi-Mortalidad via Web , SIMMOW) of the Ministry of Health of El Salvador. The total number of cases per year ranged from 161 (2017) to 215 (2016). Incidences ranged from 2.52 cases to 3.38 cases per 100,000 population per year, corresponding to the years 2017 and 2016, respectively. Five deaths were recorded in the six-year period, four in 2015 and one in 2016, for a case fatality rate of 0.44%. Snakebites peaked during the rainy season (May to November) and mostly affected people in the age groups of 10–30 years. The male/female ratio was 1.59. The Departments (local political units) showing the highest number of cases were Santa Ana, Libertad, Chalatenango, Sonsonate, and La Unión. Most cases were attended at departmental and regional hospitals (second level of attention). The incidence and mortality due to snakebite envenoming in El Salvador are the lowest reported for Central America. This may be related to the fact that Bothrops asper , the medically most important snake species in the region, is not distributed in El Salvador, where the rattlesnake Crotalus simus predominates. Image 1 • The main epidemiological features of snakebites in El Salvador for the period 2014–2019 are described. • A total of 1130 cases were registered for this period, for an annual mean of 188 cases. • Incidence ranged from 2.52 to 3.38 cases per 100,000 population per year, for the years 2017 and 2016, respectively. • Five deaths were recorded for this six-year interval. • El Salvador has the lowest incidence of snakebites in the whole Central American region. [ABSTRACT FROM AUTHOR]