1. Estrogenic activity of a naringinase-treated extract of Sophora japonica cultivated in Egypt.
- Author
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El-Halawany AM, Chung MH, Abdallah HM, Nishihara T, and Hattori M
- Subjects
- Benzopyrans chemistry, Benzopyrans isolation & purification, Benzopyrans metabolism, Benzopyrans pharmacology, Digestion, Drug Discovery, Egypt, Estrogen Antagonists chemistry, Estrogen Antagonists isolation & purification, Estrogen Antagonists metabolism, Estrogen Antagonists pharmacology, Estrogen Receptor alpha agonists, Estrogen Receptor alpha genetics, Estrogen Receptor beta agonists, Estrogen Receptor beta genetics, Genistein analysis, Genistein chemistry, Genistein metabolism, Genistein pharmacology, Kaempferols chemistry, Kaempferols isolation & purification, Kaempferols metabolism, Kaempferols pharmacology, Molecular Structure, Osmolar Concentration, Phytoestrogens chemistry, Phytoestrogens isolation & purification, Phytoestrogens metabolism, Phytotherapy, Plant Extracts chemistry, Plant Extracts metabolism, Spectrometry, Mass, Electrospray Ionization, Two-Hybrid System Techniques, Yeasts drug effects, Yeasts genetics, Yeasts growth & development, Multienzyme Complexes metabolism, Phytoestrogens pharmacology, Plant Extracts pharmacology, Seeds chemistry, Sophora chemistry, beta-Glucosidase metabolism
- Abstract
The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity. Through bioassay-guided isolation of the main active constituents from the naringinase-treated methanol extract of S. japonica, the aglycones genistein and kaempferol were found to be the main phytoestrogens in the naringinase-treated extract. In addition, kaempferol was nearly equipotent to genistein as an estrogen agonist. Concerning the compounds isolated from the untreated methanol extract, sophoricoside showed weak estrogenic activity on ERbeta only.
- Published
- 2010
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