1. Coumamarin: a first coumarinyl calcium complex isolated from nature.
- Author
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Hamed A, Abdel-Razek AS, Frese M, Sproß J, Stammler HG, Sewald N, and Shaaban M
- Subjects
- Aspergillus classification, Aspergillus genetics, Aspergillus isolation & purification, Biological Products chemistry, Cluster Analysis, DNA, Fungal chemistry, DNA, Fungal genetics, DNA, Ribosomal chemistry, DNA, Ribosomal genetics, Egypt, Indian Ocean, Molecular Structure, Phylogeny, RNA, Ribosomal, 18S genetics, Seawater microbiology, Sequence Analysis, DNA, Spectrum Analysis, Aspergillus chemistry, Biological Products isolation & purification
- Abstract
The first calcium complex from nature, Coumamarin (1), 7-hydroxy-3-methoxy-2-oxo-2H-chromene-6-carboxylate Ca(II) complex, was isolated from Aspergillus sydowii ASTI, together with diorcinol (2), violaceol I (3), hydroxysydonic acid (4), cyclo (Trp-Phe), kojic acid, ergosterol, and uracil. The producing strain was isolated from marine water sample collected from Tiran Island, Red Sea, Egypt. Structure 1 was assigned by intensive 1D, 2D NMR, HR-ESIMS, and X-ray crystallography as well. Coumamarin is potentially active against certain tested bacteria and yeasts, while showing no cytotoxic activity against human cervix carcinoma cell line (KB-3-1). Taxonomically, the fungus was identified by phylogenetic analysis of its 18S rRNA gene sequence.
- Published
- 2019
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