21 results on '"Khatib A"'
Search Results
2. Egypt's Human Rights Record Is Overshadowing COP27.
- Author
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Khatib, Lina
- Subjects
HUMAN rights ,TORTURE - Abstract
In the runup to COP27, the restrictions Egyptian authorities placed on the participation of civil society groups at the summit drew international attention and were criticized by many as needlessly punitive. Germany also invited Abd el-Fattah's sister, Sanaa Seif, to speak alongside Egyptian and international human rights defenders at the country's COP27 pavilion on Nov. 8. [Extracted from the article]
- Published
- 2022
3. Effect of heavy metals in irrigation water of different fish farms on the quality of cultured fish.
- Author
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El-Khatib, Zakaria I. M., Azab, Ahmad M., Abo-Taleb, Hamdy A. H., Al-Absawy, Ahmed N. M., and Toto, Mohamed M. M.
- Subjects
- *
FISH farming , *HEAVY metal content of water , *HEAVY metals , *IRRIGATION water , *FISH quality , *IRRIGATION water quality , *HEAVY metal toxicology - Abstract
The present study aimed to study the effect of irrigation water quality in different fish farms in Egypt on the quality of Nile tilapia, Oreochromis niloticus, produced from these fish farms. Four fish farms (El-Abbasa, Edko, Mariout and Bahr El-Baqar) which irrigated with different water sources were selected to study the effect of some heavy metals (iron, copper, zinc and lead) on fish quality produced from these farms during the period of fish culturing from April 2018 to November 2018. Results indicated that most of the highest averages of all heavy metal concentrations in water, sediment and fish muscular tissues were recorded from Bahr El-Baqar fish farm and their lowest values from El-Abbasa fish farm. The highest contamination factors for most heavy metals were recorded in Bahr El-Baqar fish farm and the lowest in El-Abbasa fish farm. The present study concluded that El-Abbassa fish farm has low pollution and the other fish farms (Edko, Mariout, and Bahr El-Baqar) have progressive deterioration of the site quality. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Knowledge of the Egyptian emergency physicians about the use of rt-PA in acute ischemic stroke.
- Author
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El-khatib, Mohamed El-Sayed, El Ahwal, Shereen Ahmed, Masoud, Muhammad, and El Mously, Sherine
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EMERGENCY physicians , *TISSUE plasminogen activator , *PHYSICIAN services utilization , *STROKE , *BLOOD sugar - Abstract
Background: The administration of recombinant tissue plasminogen activator (rt-PA) has increased the focus on acute ischemic stroke (AIS) as an emergency condition. The emergency physicians have to rapidly recognize the patients who are candidates for rt-PA and refer them to the specialized stroke team within the proper time window. The knowledge of the emergency physicians about the benefit and the drawbacks of this therapy is crucial and it affects their attitudes towards its use. Objective: To apply a survey on the Egyptian emergency physicians aiming to investigate their knowledge about the use rt-PA therapy in AIS. Methodology: A self-administered questionnaire was sent to the emergency physicians who are working in three Egyptian governorates. Results: Out of 120 emergency physicians, the total knowledge of the study group was good with a score of 7 ± 1.8/11. Most of the participants mentioned the correct answers (over 50%) for all items except for one question regarding the blood glucose control before the use of rt-PA. Significant positive correlation was noted between the knowledge score and the age. Conclusions: The surveyed emergency physicians had a good knowledge about the use of rt-PA in AIS, yet, this knowledge is mainly theoretical. Therefore, tutorials, clinical training, and active engagement in the stroke care team are warranted to improve their clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
5. Prevalence of trachoma in four marakez of Elmenia and Bani Suef Governorates, Egypt.
- Author
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Amer, Khaled, Müller, Andreas, Abdelhafiz, Hussein Mohamed, Al-Khatib, Tawfik, Bakhtiari, Ana, Boisson, Sophie, El Arab, Gamal Ezz, Gad, Hema, Gordon, Bruce A., Madian, Ahmad, Mahanna, Ahmed Tarek, Mokhtar, Samir, Safa, Omar H., Samy, Mohamed, Shalaby, Mohammad, Taha, Ziad Atta, Willis, Rebecca, Yacoub, Ashraf, Mamdouh, Abdul Rahman, and Younis, Ahmed Kamal
- Subjects
TRACHOMA ,EYE diseases ,EPIDEMIOLOGY ,PUBLIC health ,DISEASE mapping ,SOCIAL history - Abstract
Purpose: In 2015, to determine where interventions are needed to eliminate trachoma as a public health problem from Egypt, we initiated population-based prevalence surveys using the Global Trachoma Mapping Project platform in four suspected-endemic marakez (districts; singular: markaz) of the governorates of Elmenia and Bani Suef. Methods: In each markaz, 30 households were selected in each of 25 villages. Certified graders examined a total of 3682 children aged 1-9 years in 2993 households, noting the presence or absence of trachomatous inflammation—follicular (TF) and trachomatous inflammation—intense (TI) in each eye. A total of 5582 adults aged ≥15 years living in the same households were examined for trachomatous trichiasis (TT). Household-level access to water and sanitation was recorded. Results: Three of four marakez had age-adjusted TF prevalence estimates in 1-9-year olds of >10%; the other markaz had a TF prevalence estimate of 5-9.9%. Estimates of the age- and gender-adjusted prevalence of unmanaged TT in adults ranged from 0.7% to 2.3%. Household-level access to water and sanitation was high. (We did not, however, measure use of water or sanitation facilities.) Conclusions: Each of the four marakez surveyed has trachoma as a public health problem, with a need for implementation of the SAFE (surgery, antibiotics, facial cleanliness, environmental improvement) strategy. Further mapping is also required to determine the need for interventions in other areas of Egypt. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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6. Impact of perceptual biases on cultural perception towards the ‘other’: the case of Egypt versus the European Union.
- Author
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Khatib, Hakim
- Subjects
ELECTIONS ,RELIGIOUS movements ,PRAGMATISM - Abstract
The empirical literature has focused on political, socio-economic and even religious indicators when attempting to understand the rise of Islamic factions in Egypt, thereby minimizing the role of cultural aspects in driving mobilization and contestation processes in the Arab World. With this issue in mind, this paper focuses on the alteration of cultural perception of the public through the capitalization of perceptual biases. The contribution of European Union policies in the region has served as useful material for the Islamic rhetoric of the ‘Salafi Call’ and the Muslim Brotherhood in creating a European Union-sceptical culture to contest and mobilize for the elections in 2012 in Egypt. Based on the sixth edition of Jerald Greenberg and Robert Baron'sBehavior in Organizations(London, 1997), perceptual biases of stereotyping, which may distort the image of the target collective, and comparative examples of Islamic rhetoric from the period covering the Egyptian elections will be analyzed to demonstrate how Islamic factions took advantage of these perceptual biases to disparage the ‘West’ in the region and, at the same time, to gain more sympathy, support and legitimacy from the Egyptian people. Whilst there is a significant knowledge gap about Europe in the Arab world, clouded by generalization and stereotyping, the European Union likewise lacks accurate and up-to-date information about religious movements. Religious elites constitute a significant player in altering cultural perception in the Arab region. Pragmatism of politically active religious factions increases their impact on perception of the ‘Self’ and the ‘Other’. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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7. Oral health status and behaviours of children with Autism Spectrum Disorder: a case-control study.
- Author
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El Khatib, Amira A., El Tekeya, Magda M., El Tantawi, Maha A., and Omar, Tarek
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ACADEMIC medical centers ,AUTISM ,BEHAVIOR ,CHI-squared test ,DIET ,FISHER exact test ,ORAL hygiene ,PHYSICAL diagnosis ,QUESTIONNAIRES ,STATISTICS ,U-statistics ,SOCIOECONOMIC factors ,CASE-control method ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Background Autism Spectrum Disorder ( ASD) is a lifelong neuro-developmental disorder characterized by abnormalities in social interactions and communication and by stereotyped, repetitive activities. Purpose Assess the oral health status and behaviours of children with ASD. Methods The study included 100 children with ASD and 100 healthy children from Alexandria, Egypt. Data were collected using a questionnaire and clinical examination. Questionnaire assessed socio-demographics, medical history, dental history, oral hygiene, dietary habits, and presence of self-injurious behaviours. Clinical examination assessed behaviour during examination, gingival condition, plaque accumulation, caries, and other oral conditions. Results Children with ASD had significantly poorer oral hygiene and gingival condition than healthy children ( P < 0.001 for both). No significant differences were found in caries prevalence or experience in primary or permanent dentition. More children with ASD behaved 'negatively' or 'definitely negatively' (37% and 11%) than did healthy controls (11% and 2%) ( P < 0.0001). Self-injurious behaviour and bruxism were more practised by children with ASD (32% of children with ASD and 2% of healthy children, P < 0.001). More children with ASD had difficulty in accessing dental care ( P = 0.002). Conclusions The oral condition of children with ASD might increase the risk of developing dental diseases. Their behaviour and life factors may complicate provision of services and limit access to dental care. Therefore, individualized oral health education programmes should be implemented for those children. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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8. Nationalism and Otherness: The representation of Islamic fundamentalism in Egyptian cinema.
- Author
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Khatib, Lina
- Subjects
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NATIONALISM , *ISLAMIC fundamentalism , *RELIGION in motion pictures , *MOTION picture industry , *ISLAM , *NATIONAL character , *DEMOCRACY - Abstract
This article focuses on the representation of Islamic fundamentalism in contemporary Egyptian films. It aims to go beyond orientalism-based studies consumed with analysing the West's representation of, and thus power over, the East. The article problematizes discourses examining fundamentalism's role as the West's Other and the source of its identity by analysing the complicated political role that fundamentalism plays in Egypt as an ‘Islamic’ democracy. Islamic fundamentalism is explored as an Other in Egyptian cinema that is used as a tool for strengthening Egyptian national identity. The article thus reveals the cultural tensions and power struggles present within Egypt as a nation caught between modernity and extremism. The article's highlighting of the processes of Otherness within the ‘East’ itself reveals the limitation of the idea of an East/West dichotomy. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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9. The politics of space: the spatial manifestations of representing Middle Eastern politics in American and Egyptian cinemas.
- Author
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Khatib, Lina
- Subjects
MOTION picture theaters ,MOTION picture industry ,ISLAMIC fundamentalism ,EGYPTIAN politics & government - Abstract
This article analyses the different ways contemporary American and Egyptian films construct and understand space in the context of Middle Eastern politics. The article contrasts Hollywood's relationship with space as one about mastery, mirroring America's "from-above" approach to Middle Eastern politics, with the Egyptian films' more intimate portrayal of space, where conflicts are more localized and closer to home. Space is explored as both a physical and a mental/imagined/lived entity. In its analysis of issues like the representation of Islamic fundamentalism in the films and its spatial manifestations, the article demonstrates that political space is not a matter of core versus periphery, where "we" reside within a space and "they" outside it, but rather that old boundaries have been erased while new ones have been (re)drawn. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
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10. Trichoderma asperellum Secreted 6-Pentyl-α-Pyrone to Control Magnaporthiopsis maydis , the Maize Late Wilt Disease Agent.
- Author
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Degani, Ofir, Khatib, Soliman, Becher, Paz, Gordani, Asaf, and Harris, Raviv
- Subjects
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WILT diseases , *TRICHODERMA , *LIQUID chromatography-mass spectrometry , *PHYTOPATHOGENIC fungi , *PLANT diseases , *BIOLOGICAL pest control agents , *HAIR growth , *PLANT growth - Abstract
Simple Summary: The maize (Zea mays L.) late wilt disease, caused by the fungus Magnaporthiopsis maydis, is considered the most severe threat to commercial maize production in Israel and Egypt. Various control strategies have been inspected over the years. The current scientific effort is focusing on eco-friendly approaches against the disease. The genus Trichoderma, a filamentous soil and plant root-associated fungi, is one of the essential biocontrol species, demonstrating over 60% of all the listed biocontrol agents used to reduce plant infectious diseases. They produce different enzymes and elicit defense responses in plants, playing a significant role in biotic and abiotic stress tolerance, hyphal growth, and plant growth promotion. Trichoderma asperellum was found to have biocontrol ability and protect crops against various plant pathogenic fungi, including the maize late wilt disease causal agent. This research aimed at isolating and identifying T. asperellum secondary metabolites with antifungal action against M. maydis. From T. asperellum growth medium, the 6-Pentyl-α-pyrone secondary metabolite was isolated and identified with high potent antifungal activity against M. maydis. This compound previously exhibited antifungal activities towards several plant pathogenic fungi. Achieving clean and identified T. asperellum active ingredient(s) secreted product(s) is the first step in revealing their commercial potential as new fungicides. Follow-up studies should test this component against the LWD pathogen in potted sprouts and the field. Late wilt disease (LWD) is a destructive vascular disease of maize (Zea mays L.) caused by the fungus Magnaporthiopsis maydis. Restricting the disease, which is a significant threat to commercial production in Israel, Egypt, Spain, India, and other countries, is an urgent need. In the past three years, we scanned nine Trichoderma spp. isolates as biological control candidates against M. maydis. Three of these isolates showed promising results. In vitro assays, seedlings pathogenicity trials, and field experiments all support the bio-control potential of these isolates (or their secretions). Here, a dedicated effort led to the isolation and identification of an active ingredient in the growth medium of Trichoderma asperellum (P1) with antifungal activity against M. maydis. This Trichoderma species is an endophyte isolated from LWD-susceptible maize seeds. From the chloroform extract of this fungal medium, we isolated a powerful (approx. 400 mg/L) active ingredient capable of fully inhibiting M. maydis growth. Additional purification using liquid chromatography–mass spectrometry (LC–MS) and gas chromatography–mass spectrometry (GC–MS) separation steps enabled identifying the active ingredient as 6-Pentyl-α-pyrone. This compound is a potential fungicide with high efficiency against the LWD causal agent. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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11. Enhancement of Bentonite Materials with Cement for Gamma-Ray Shielding Capability.
- Author
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El-Khatib, Ahmed M., Elsafi, Mohamed, Almutiri, Mohamed N., Mahmoud, R. M. M., Alzahrani, Jamila S., Sayyed, M. I., and Abbas, Mahmoud I.
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MASS attenuation coefficients , *ENERGY dispersive X-ray spectroscopy , *ATTENUATION coefficients , *BENTONITE , *SCINTILLATION counters , *GAMMA rays , *RADIOACTIVE waste repositories - Abstract
The gamma-ray shielding ability of various Bentonite–Cement mixed materials from northeast Egypt have been examined by determining their theoretical and experimental mass attenuation coefficients, μm (cm2g−1), at photon energies of 59.6, 121.78, 344.28, 661.66, 964.13, 1173.23, 1332.5 and 1408.01 keV emitted from 241Am, 137Cs, 152Eu and 60Co point sources. The μm was theoretically calculated using the chemical compositions obtained by Energy Dispersive X-ray Analysis (EDX), while a NaI (Tl) scintillation detector was used to experimentally determine the μm (cm2g−1) of the mixed samples. The theoretical values are in acceptable agreement with the experimental calculations of the XCom software. The linear attenuation coefficient (μ), mean free path (MFP), half-value layer (HVL) and the exposure buildup factor (EBF) were also calculated by knowing the μm values of the examined samples. The gamma-radiation shielding ability of the selected Bentonite–Cement mixed samples have been studied against other puplished shielding materials. Knowledge of various factors such as thermo-chemical stability, availability and water holding capacity of the bentonite–cement mixed samples can be analyzed to determine the effectiveness of the materials to shield gamma rays. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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12. The Potentials of Egyptian and Indian Granites for Protection of Ionizing Radiation.
- Author
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Elsafi, Mohamed, Alrashedi, M. F., Sayyed, M. I., Al-Hamarneh, Ibrahim F., El-Nahal, M. A., El-Khatib, Mostafa, Khandaker, Mayeen Uddin, Osman, Hamid, and Askary, Ahmad El
- Subjects
ATOMIC number ,IONIZING radiation ,ATTENUATION coefficients ,RADIATION protection ,MASS attenuation coefficients ,GRANITE - Abstract
This paper aims to study the radiation shielding characteristics and buildup factor of some types of granite in Egypt. The mass attenuation coefficient (MAC) for three types of granite (gandola, white halayeb, and red aswani) was experimentally determined, and the experimental results were validated by XCOM software. The relative deviation between the two methods does not exceed 3% in all discussed granite samples, which means that MAC calculated through the experimental and XCOM are in suitable agreement. The effective atomic number (Z
eff ) varies from 13.64 to 10.69, 13.68 to 10.59, and 13.45 and 10.66 for gandola, white halayeb, and red aswani, respectively. As well as the equivalent atomic number (Zeq ) was calculated in a wide range of energy to deduce the exposure (EBF) and energy absorption (EABF) buildup factors for the studied granite materials. The linear attenuation coefficient (LAC), half-value layer (HVL), mean free path (MFP) were calculated at each investigated energy and showed that the most effective shielding ability at high energy was red aswani, while at low energy, the shielding ability was nearly constant for studied granites. The present study forms the first endeavor to obtain the radiation shielding properties of the studied materials to be used in practical applications. [ABSTRACT FROM AUTHOR]- Published
- 2021
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13. The Taboo of Atheism in Egypt.
- Author
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Khatib, Hakim
- Subjects
ATHEISTS - Abstract
The article discusses the discrimination against atheists in Egypt triggered by conservative social traditions and state religious establishments.
- Published
- 2016
14. Don't Blaspheme in Egypt.
- Author
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Khatib, Hakim
- Subjects
BLASPHEMY lawsuits - Abstract
The article reports on the imprisonment of Islamic scholar and theologian Islam Al-Buhairi as sentenced by the Egyptian court for blasphemy which is considered as the country's fascist law based on article 98 of the Egyptian Penal Code.
- Published
- 2016
15. Communication and Political Awareness in the Villages of Egypt.
- Author
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Hirabayashi, Gordon K. and El Khatib, M. Fathalla
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POLITICAL planning ,LITERACY ,SOCIAL surveys ,RURAL population ,CENSUS - Abstract
The article explores communication and political awareness in villages of Egypt. The Province of Menoufia, in the center of Lower Egypt, contains five villages reported on in this paper. Menoufia presents both an over-populated and densely populated area, higher than the national average. While rural illiteracy is still high, the rate is decreasing. At the same time mass communication is spreading, with newspapers, magazines and radios reaching even remote villages. While Menoufia is considered to have the highest literacy rate in Egypt outside the urban centers, the official 1947 census indicates that the literacy rate was only 20 per cent. As between newspapers and radio exposure, there was considerable variation in preferred contents and program. When interviewees were asked about differences between a plebiscite and an election, no female was able to distinguish between them and only 20 per cent of the males were able to do so. According to findings of this study, Egyptian villagers are definitely emerging as a nationally conscious group.
- Published
- 1958
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16. Exploring natural products-based cancer therapeutics derived from egyptian flora.
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El-Seedi, Hesham R., Yosri, Nermeen, Khalifa, Shaden A.M., Guo, Zhiming, Musharraf, Syed Ghulam, Xiao, Jianbo, Saeed, Aamer, Du, Ming, Khatib, Alfi, Abdel-Daim, Mohamed M., Efferth, Thomas, Göransson, Ulf, and Verpoorte, Rob
- Subjects
- *
THERAPEUTIC use of antineoplastic agents , *HERBAL medicine , *QUERCETIN , *RUTIN , *TRADITIONAL medicine , *TUMORS , *PHYTOCHEMICALS , *PLANT extracts , *RESVERATROL ,THERAPEUTIC use of plant extracts - Abstract
Egyptian plants are a rich source of natural molecules, representing considerable biodiversity due to climate variations between the Northern, Southern, Eastern and Western regions of the country. Sinai is considered a precious nature reserves preserving flora, fauna, marine organisms, and historical habitats with ancient origins. Here, traditional medicinal approaches have been used for hundreds of years. Healthy lifestyles, low levels of stress and microbial infections, and a dependence on flora and herbal medicine might in combination explain why the burden of cancer is lower in some regions than in others. The primary aim of this review is to document the plants and natural products that are used as foods and medicines in Egypt, in general, and in Sinai, in particular, with a focus on those with demonstrated anticancer activities. The documented traditional uses of these plants are described, together with their chemical and pharmacological activities and the reported outcomes of clinical trials against cancer. A literature search was performed to identify texts describing the medicinal plants that are cultivated and grown in Egypt, including information found in textbooks, published articles, the plant list website (http://www.theplantlist.org/), the medicinal plant names services website (http://mpns.kew.org/mpns-portal/), and web databases (PubMed, Science Direct, and Google Scholar). We collected data for most of the plants cultivated or grown in Egypt that have been previously investigated for anticancer effects and reported their identified bioactive elements. Several plant species, belonging to different families and associated with 67 bioactive compounds, were investigated as potential anticancer agents (in vitro studies). The most potent cytotoxic activities were identified for the families Asteraceae, Lamiaceae, Chenopodiaceae, Apocynaceae, Asclepiadaceae, Euphorbiaceae, Gramineae, and Liliaceae. The anticancer activities of some species, such as Punica granatum L., Nerium oleander L., Olea europea L. , Matricaria chamomilla L., Cassia acutifolia L., Nigella sativa L., Capsicum frutescens L., Withania somnifera L., and Zingiber officinale Roscoe, have been examined in clinical trials. Among the various Egyptian plant habitats, we found that most of these plants are grown in the North Sinai, New-Delta, and Giza Governorates. In this review, we highlight the role played by Egyptian flora in current medicinal therapies and the possibility that these plants may be examined in further studies for the development of anticancer drugs. These bioactive plant extracts form the basis for the isolation of phytochemicals with demonstrated anticancer activities. Some active components derived from these plants have been applied to preclinical and clinical settings, including resveratrol, quercetin, isoquercetin, and rutin. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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17. Responses of Eucalyptus globulus and Ficus nitida to different potential of heavy metal air pollution.
- Author
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El-Khatib AA, Youssef NA, Barakat NA, and Samir NA
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- Biodegradation, Environmental, Egypt, Air Pollution, Eucalyptus, Ficus, Metals, Heavy analysis, Soil Pollutants
- Abstract
The present study aimed to explore the tolerance potential of Cd, Pb and Cu and physiological alterations in two common tree species growing in Minia governorate (Egypt) namely: Eucalyptus globulus and Ficus nitida and to investigate the leaf features [leaf area (LA) and specific leaf area (SLA)] associated with the phytoremediation process. The findings may be useful for future surveillance as preliminary reference values for levels of heavy metals in urban and industrial settings. The levels of cadmium, lead and Cupper in plant leaf were determined. The results showed that heavy metals could inhibit the growth of plants including LA and SLA. The water content (WC) and photosynthetic pigments of Eucalyptus and Ficus decreased with the increased concentration of metals. Contrary to chlorophylls (a) and (b), carotenoids and chlorophyll ratio (a/b) showed a significant increase with increasing metals concentration especially that of Cd and Cu. Proline content was relatively increased and soluble carbohydrate content decreased in plants with high metal accumulation. Eucalyptus showed better tolerance capacity for Cd, Pb and Cu when compared to Ficus. The ability of Eucalyptus to accumulate and tolerate metal stress makes this species a good candidate to recuperate heavy metals-contaminated conditions.
- Published
- 2020
- Full Text
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18. Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging.
- Author
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Gomaa AI, Al-Khatib A, Abdel-Razek W, Hashim MS, and Waked I
- Subjects
- Adult, Area Under Curve, Ascites mortality, Ascites therapy, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular mortality, Carcinoma, Hepatocellular therapy, Chi-Square Distribution, Egypt, Female, Humans, Kaplan-Meier Estimate, Liver Neoplasms blood, Liver Neoplasms mortality, Liver Neoplasms therapy, Male, Middle Aged, Models, Biological, Multivariate Analysis, Neoplasm Staging, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, ROC Curve, Risk Factors, Tertiary Care Centers, Time Factors, Treatment Outcome, Ascites diagnosis, Carcinoma, Hepatocellular diagnosis, Decision Support Techniques, Liver Neoplasms diagnosis, alpha-Fetoproteins analysis
- Abstract
Aim: To assess how ascites and alpha-fetoprotein (AFP) added to the Barcelona Clinic Liver Cancer (BCLC) staging predict hepatocellular carcinoma survival., Methods: The presence of underlying cirrhosis, ascites and encephalopathy, Child-Turcotte-Pugh (CTP) score, the number of nodules, and the maximum diameter of the largest nodule were determined at diagnosis for 1060 patients with hepatocellular carcinoma at a tertiary referral center for liver disease in Egypt. Demographic information, etiology of liver disease, and biochemical data (including serum bilirubin, albumin, international normalized ratio, alanine and aspartate aminotransferases, and AFP) were evaluated. Staging of the tumor was determined at the time of diagnosis using the BCLC staging system; 496 patients were stage A and 564 patients were stage B. Patients with mild ascites on initial ultrasound, computed tomography, or clinical examination, and who had a CTP score ≤ 9 were included in this analysis. All patients received therapy according to the recommended treatment based on the BCLC stage, and were monitored from the time of diagnosis to the date of death or date of data collection. The effect of the presence of ascites and AFP level on survival was analyzed., Results: At the time the data were censored, 123/496 (24.8%) and 218/564 (38.6%) patients with BCLC stages A and B, respectively, had died. Overall mean survival of the BCLC A and B patients during a three-year follow-up period was 31 mo [95% confidence interval (95%CI): 29.7-32.3] and 22.7 mo (95%CI: 20.7-24.8), respectively. The presence of ascites, multiple focal lesions, large tumor size, AFP level and CTP score were independent predictors of survival for the included patients on multivariate analysis (P < 0.001). Among stage A patients, 18% had ascites, 33% had AFP ≥ 200 ng/mL, and 8% had both. Their median survival in the presence of ascites was shorter if AFP was ≥ 200 ng/mL (19 mo vs 24 mo), and in the absence of ascites, patients with AFP ≥ 200 ng/mL had a shorter survival (28 mo vs 39 mo). For stage B patients, survival for the corresponding groups was 12, 18, 19 and 22 mo. The one-, two-, and three-year survival rates for stage A patients without ascites and AFP < 200 ng/mL were 94%, 77%, and 71%, respectively, and for patients with ascites and AFP ≥ 200 ng/mL were 83%, 24%, and 22%, respectively (P < 0.001). Adding ascites and AFP ≥ 200 ng/mL improved the discriminatory ability for predicting prognosis (area under the curve, 0.618 vs 0.579 for BCLC, P < 0.001)., Conclusion: Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma.
- Published
- 2015
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19. Heavy metal biomonitoring and phytoremediation potentialities of aquatic macrophytes in River Nile.
- Author
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Fawzy MA, Badr Nel-S, El-Khatib A, and Abo-El-Kassem A
- Subjects
- Adaptation, Physiological, Biodegradation, Environmental, Egypt, Plants metabolism, Rivers chemistry, Water Pollutants, Chemical analysis, Water Pollution, Chemical statistics & numerical data, Environmental Monitoring, Metals, Heavy analysis, Plant Development, Water Pollutants, Chemical metabolism
- Abstract
The concentrations of Cd, Cu, Pb, and Zn in sediments, water, and different plant organs of six aquatic vascular plant species, Ceratophyllum demersum L. Echinochloa pyramidalis (Lam.) Hitchc. & Chase; Eichhornia crassipes (Mart.) Solms-Laub; Myriophyllum spicatum L.; Phragmites australis (Cav.) Trin. ex Steud; and Typha domingensis (Pers.) Poir. ex Steud, growing naturally in the Nile system (Sohag Governorate), were investigated. The aim was to define which species and which plant organs exhibit the greatest accumulation and evaluate whether these species could be usefully employed in biomonitoring and phytoremediation programs. The recorded metals in water samples were above the standard levels of both US Environmental Protection Agency and Egyptian Environmental Affairs Agency except for Pb. The concentrations of heavy metals in water, sediments, and plants possess the same trend: Zn > Cu > Pb > Cd which reflects the biomonitoring potentialities of the investigated plant species. Generally, the variation of heavy element concentrations in water and sediments in relation to site and season, as assessed by two-way repeated measured ANOVA, was significant (p < 0.05). However, insignificant variations were observed in the concentrations of Pb and Cd in sediments in relation to season and of Cu and Zn in relation to site. Results also showed that the selectivity of the heavy elements for the investigated plants varied significantly (p < 0.05) with species variation. The accumulation capability of the investigated species could be arranged according to this pattern: C. demersum > E. crassipes > M. spicatum > E. pyramidalis > T. domingensis > P. australis. On the basis of the element concentrations, roots of all the studied species contain higher concentrations of Cu and Zn than shoots while leaves usually acquire the highest concentrations of Pb. Cd concentrations among different plant organs are comparable except in M. spicatum where the highest Cd concentrations were recorded in the leaves. Our results also demonstrated that all the studied species can accumulate more than 1,450-fold the concentration of the investigated heavy elements in water rendering them of interest for use in phytoremediation studies of polluted waters. Given the absence of systematic water quality monitoring, heavy elements in plants, rather than sediments, provide a cost-effective means for assessing heavy element accumulation in aquatic systems during plant organ lifespan.
- Published
- 2012
- Full Text
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20. The response of some common Egyptian plants to ozone and their use as biomonitors.
- Author
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El-Khatib AA
- Subjects
- Chlorophyll, Egypt, Malva drug effects, Medicago drug effects, Melilotus drug effects, Plant Leaves drug effects, Sonchus drug effects, Air Pollutants adverse effects, Environmental Monitoring methods, Ozone adverse effects, Plants drug effects
- Abstract
Relative sensitivity of five common Egyptian plant species namely, Senecio vulgaris, Malva parviflora, Sonchus oleraceus, Medicago sativa and Melilotus indicus to elevated levels of ozone has been studied. The plants were exposed to charcoal filtered air (CFA) and different levels of O3 (50 and 100 ppb) for 5 h per day. The studied parameters were recorded for five consecutive days after fumigation. The foliar injury varied significantly among species in a dose-dependent manner. Severe injury symptoms were recorded on the leaves of M. sativa. With the exception of M. parviflora, all species exhibited significant increases in the percentage reduction of the above-ground dry weight as a result of reductions in both leaf and stem dry weights. M. sativa showed a marked reduction in its relative growth rate at elevated levels of O3. The extent of chlorophyll a destruction was higher in both M. sativa and S. oleraceus than in the other species tested. No differences in the sensitivity of chlorophylls a+b and carotenoids to ozone levels were recorded in this work. Percentage reduction of ascorbic acid was higher in M. sativa and S. oleraceus, compared with the other species studied. With respect to relative percentages of proline, there was a significant difference in the responses of plants to ozone. According to the ozone resistance (R%), measured as relative growth rate, the test species were arranged in the descending order: M. parviflora>M. Indicus>S. Vulgaris>S. Oleraceus>M. sativa. In M. sativa, both determinant and correlation coefficients are well reflected in the relationship between its physiological response, its performance and ozone levels, supporting its recommendation as a candidate for biomonitoring in Egypt.
- Published
- 2003
- Full Text
- View/download PDF
21. A study of some trace elements in fingernail and hair of Egyptian bilharzial patients using short neutron activation.
- Author
-
el-Khatib AM and el-Mohandes A
- Subjects
- Adult, Egypt, Humans, Male, Neutron Activation Analysis, Hair chemistry, Nails chemistry, Schistosomiasis mansoni metabolism, Trace Elements analysis
- Abstract
The concentration of 10 elements has been determined in fingernail and hair of four groups representing normal and hepatosplenic (bilharzial) subjects. Samples were collected from rural inhabitants to the east of Alexandria City and irradiated with thermal neutrons from a Triga Mark III Reactor, for 10 minutes. Measurements were made using HPGe detector, ADC and PDP 11/34. The analysis were performed using the RAYGUNprogram. The results showed an increase in the concentration of Al, Cl and I in both fingernail and hair of bilharzial patients than normal while Mg, Ca, K, Mn, Cu, and Sr decreased. Most of the elements showed a higher concentration in fingernail than in hair.
- Published
- 1992
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