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This paper provides a novel, unique, and improved optimization algorithm called the modified Orca Predation Algorithm (mOPA). The mOPA is based on the original Orca Predation Algorithm (OPA), which combines two enhancing strategies: Lévy flight and opposition-based learning. The mOPA method is proposed to enhance search efficiency and avoid the limitations of the original OPA. This mOPA method sets up to solve the global optimization issues. Additionally, its effectiveness is compared with various well-known metaheuristic methods, and the CEC'20 test suite challenges are used to illustrate how well the mOPA performs. Case analysis demonstrates that the proposed mOPA method outperforms the benchmark regarding computational speed and yields substantially higher performance than other methods. The mOPA is applied to ensure that all load demand is met with high reliability and the lowest energy cost of an isolated hybrid system. The optimal size of this hybrid system is determined through simulation and analysis in order to service a tiny distant location in Egypt while reducing costs. Photovoltaic panels, biomass gasifier, and fuel cell units compose the majority of this hybrid system's configuration. To confirm the mOPA technique's superiority, its outcomes have been compared with the original OPA and other well-known metaheuristic algorithms. [ABSTRACT FROM AUTHOR]

Peptic ulcer associated with H. pylori infection and antibiotics resistance warranted the execution of the foregoing study to produce natural and safe alternatives. GC-MS analysis of the essential oil derived from the ripe and unripe peel of Citrus sinensis var. Valencia grown in Egypt was investigated besides its anti-Helicobacter pylori and COX-2 inhibition actions. Ripe mature peels displayed a higher oil yield than unripe ones (0.8 and 0.6%, respectively). Twenty-nine compounds were identified in all samples with volatile monoterpenes as the predominant class, (88.90% and 90.62% in fresh ripe peel (P1) and dried ripe peel (P2), respectively, however unripe fresh orange peel (P3) showed a lower quantity (83.95%). D-Limonene was the major compound in P1 and P2 (85% and 88 %, respectively), while 73% were found in P3. In comparison to standard Clarithromycin (MIC90 = 1.95 ± 0.002 μg/ml), the nano-hexosomal formula of P1 reduced H. pylori action more than P1 alone with MIC90= 1.95 ± 0.0029 μg/ml and MIC90= 3.90 ± 0.006 μg/ml for formulated and unformulated P1, respectively. An anti-inflammatory assay via COX-2 inhibition revealed that the formulated P1 is more potent (IC50= 0.85 μg/ml) than P1 alone (IC50= 2.04 μg/ml) in comparison with Celecoxib® (IC50= 0.28 μg/ml). To unravel the mechanism of the anti-Helicobacter pylori activity, an in silico study on D-Limonene has been performed, using H. pylori urease enzyme, which revealed that D-Limonene showed promising binding scores. Thus, Valencia orange peel essential oil offers a natural, cheap, and relatively safe candidate to combat Helicobacter pylori infection. [ABSTRACT FROM AUTHOR]