1. Sulfated triterpene derivatives from Fagonia arabica.
- Author
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Perrone A, Masullo M, Bassarello C, Hamed AI, Belisario MA, Pizza C, and Piacente S
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Drug Screening Assays, Antitumor, Egypt, Humans, Molecular Structure, Sulfuric Acid Esters chemistry, Sulfuric Acid Esters pharmacology, Triterpenes chemistry, Triterpenes pharmacology, Antineoplastic Agents, Phytogenic isolation & purification, Plants, Medicinal chemistry, Sulfuric Acid Esters isolation & purification, Triterpenes isolation & purification, Zygophyllaceae chemistry
- Abstract
Two new sulfated triterpenes (1, 6) and four new sulfated triterpene glycosides (2-5) have been isolated from the aerial parts of Fagonia arabica. Their structures were established by spectroscopic data analysis. Compounds 1/2 and 3/4 are sulfated derivatives of the rare sapogenins 3beta,27-dihydroxyolean-12-en-28-oic acid and 3beta,27-dihydroxyurs-12-en-28-oic acid, respectively. Compound 5 is an unusual disulfated oleanene derivative characterized by the occurrence of a 13,18-double bond, while compound 6 is the first reported naturally occurring saturated and sulfated pentacyclic triterpene of the taraxastane series with a C-20,28 lactone unit.
- Published
- 2007
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