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BACKGROUND Artemisia capillaris is among the most abundantly used traditional medicines, utilized in East Asia to treat diverse illnesses, including gastrointestinal tract diseases. We previously reported that an aqueous extract of A. capillaris (AEAC) inhibited gastric inflammation induced by HCl/ethanol via reactive oxygen species scavenging and NF‐κB downregulation. To date, the pharmacological potential of AEAC for promoting mucosal integrity has not been studied. RESULTS: Here, we report that a single treatment with AEAC increased mucus production, and repeated administration of AEAC abolished HCl/ethanol‐induced mucosal injury in vivo. Single‐ and multiple‐dose AEAC treatments measurably increased the expression of mucosal stabilizing factors in vivo, including mucin (MUC) 5 AC, MUC6, and trefoil factor (TFF) 1 and TFF2 (but not TFF3). AEAC also induced mucosal stabilizing factors in both SNU‐601 cells and RGM cells through phosphorylation of extracellular signal‐regulated kinases. CONCLUSION: Taken together, our results suggest that AEAC protects against HCl/ethanol‐induced gastritis by upregulating MUCs and TFFs and stabilizing the mucosal epithelium. © 2021 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

The article presents the case study of a 45 year old female patient who was born with erythema lesions in the right nuchal and occipital area. The lesions were flat and non-hypertrophic. Recently several nodules began forming above the erythema. The biopsy is performed in the nodules and flat erythema lesion site in the nuchal area and the tissues were sent for pathologic and genetic study.