1. Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage
- Author
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Wang, Yanchao, Su, Wei, Zhang, Cuiyu, Xue, Changhu, Chang, Yaoguang, Wu, Xiaolin, Tang, Qingjuan, and Wang, Jingfeng
- Subjects
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SEA cucumbers , *PEPTIC ulcer , *NUTRITION , *MITOGEN-activated protein kinases , *METALLOPROTEINASES , *BODY weight , *FOOD consumption , *ETHANOL - Abstract
Abstract: Sea cucumber is a nutritional aquatic food that is widely consumed in East Asian countries. Employing a rat model of ethanol-induced gastric ulcer, we examined the protective effect of sea cucumber fucoidan (SC-FUC) extracted from Acaudina molpadioides and explored the related mechanisms. Oral administration with 100mg/kg body weight SC-FUC for 5days can significantly prevent the formation of gastric ulcer. Moreover, SC-FUC pretreatment could alleviate ethanol-induced histological damage, reverse changes in tissue oxidation and antioxidase activities, and regulate the signalling pathways of mitogen-activated protein kinases and matrix metalloproteinases. This study investigated the ethanol-induced gastric ulcer protective effect of SC-FUC for the first time, and elucidated that the protective mechanisms included anti-oxidation, gastric matrix hydrolysis suppression, and anti-inflammation. [Copyright &y& Elsevier]
- Published
- 2012
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