1. Y-Chromosome Evidence of Southern Origin of the East Asian-Specific Haplogroup O3-M122.
- Author
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Hong Shi, Yong-li Dong, Bo Wen, Chun-Jie Xiao, Underhill, Peter A., Pei-Dong Shen, Chakraborty, Ranajit, Li Jin, and Bing Su
- Subjects
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Y chromosome abnormalities , *SEX chromosome abnormalities , *HUMAN chromosome abnormality diagnosis , *GENETIC testing , *MEDICAL screening - Abstract
The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred ∼25,000–30,000 years ago, consistent with the fossil records of modern humans in East Asia. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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