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Copyright of Advances in Atmospheric Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A systematic research flow was applied to the Southern Metropolis in Taiwan not only to recount residents' considerations in this cultural area but also to compare them with those of other metropolitans on the island in relation to general housing concerns. The constructs and factors in housing decision-making were justified using the literature, confirmed with experts in the field, and organised as a decision hierarchy that formed the foundation of a survey. The investigation combined the analytic hierarchy process and Student's t-test, both of which are credible methods, to facilitate a grounded process for mind mining. The importance of constructs/factors were thus assessed on a numerical basis, and a set of unforeseen insights were explored for the different parties of interest (e.g., buyers, construction companies, agents, asset managers, etc.). Opinion gaps between different sample groups were identified. This set of empirical knowledge filled the gap in the literature. It is noteworthy that among the constructs in the region studied, (housing) 'conditions' dominated 'price', while 'location and transport' was the least important. A 'non-paradigmatic shift' in people's total housing preference structure, which changed gradually with decreasing population density and increasing plain geography from the north to the south between nearby metropoles, was observed, despite the niche but commensurable cultural norm in East Asia being the overall scenario of the island. Some existing claims about the housing preferences in this area were also either supported or rebutted by the quantitative evidence(s). [ABSTRACT FROM AUTHOR]

Background & Aims: Large‐scale data regarding the real‐world effectiveness and safety of glecaprevir/pibrentasvir (GLE/PIB) for patients with chronic hepatitis C virus (HCV) infection were limited in East Asia. We aimed to evaluate the clinical performance of GLE/PIB in different HCV populations in Taiwan. Methods: A total of 658 chronic HCV patients with compensated liver diseases receiving GLE/PIB for 8 (n = 549), 12 (n = 103) or 16 (n = 6) weeks were retrospectively enrolled. The effectiveness was determined by sustained virologic response at off‐therapy 12 weeks (SVR12). Patient characteristics potentially related to SVR12 and the safety profiles were also assessed. Results: By evaluable population (EP) and per‐protocol (PP) analyses, the overall SVR12 rate was 98.2% (95% confidence interval (CI): 96.8%‐99.0%) and 99.4% (95% CI: 98.4%‐99.8%). The SVR12 rates were 98.9% (95% CI: 97.6%‐99.5%), 94.2% (95% CI: 87.9%‐97.3%) and 100% (95% CI: 60.1%‐100%) in patients receiving 8, 12 and 16 weeks of treatment respectively. A total of 656 (99.7%) patients completed the scheduled treatment. The SVR12 rates were comparable regardless of baseline characteristics or week 4 viral decline. Twenty (3.0%) patients had serious adverse events (AEs), but none were not related to GLE/PIB. The two most common AEs were pruritus (7.8%) and fatigue (5.5%). Two (0.3%) and no patients had ≥3‐fold upper limit of normal (ULN) for total bilirubin and alanine aminotransferase (ALT) levels. Conclusions: GLE/PIB for 8‐16 weeks is effective and well‐tolerated for patients with chronic HCV infection in Taiwan. [ABSTRACT FROM AUTHOR]

Background and Aim: Data regarding the efficacy and safety of paritaprevir/ritonavir, ombitasvir plus dasabuvir (PrOD) for East Asian non‐cirrhotic hepatitis C virus genotype 1b (HCV GT1b) patients receiving hemodialysis were limited. Methods: Forty‐six HCV GT1b non‐cirrhotic patients receiving hemodialysis who received PrOD for 12 weeks were prospectively enrolled in seven academic centers in Taiwan. The primary efficacy endpoint was sustained virologic response 12 weeks off‐therapy (SVR12). Patients' baseline characteristics, early virokinetics, and HCV resistance‐associated substitutions (RASs) potentially related to SVR12 were analyzed. The safety profiles were also assessed. Results: The SVR12 rate was 100% (46 of 46 patients). Patients' baseline characteristics, on‐treatment viral decline, and baseline HCV resistance‐associated substitutions did not affect SVR12. All patients tolerated treatment well. One patient with folliculitis temporarily discontinued treatment, and another two patients had serious adverse events (SAEs), which were considered not related to PrOD treatment. The common adverse events were pruritus (19.6%), fatigue (15.2%), and upper respiratory tract infection (6.5%). Twelve (19.6%) and one (2.2%) patients had hemoglobin levels < 10 and 8.5 g/dL, respectively, which were related to renal impairment. Five (10.9%) patients had on‐treatment total bilirubin level of 1.5–3.0 mg/dL, but none developed hepatic decompensation. The bilirubin levels peaked at week 1 of treatment and then declined with continuous treatment. Conclusion: Treatment with PrOD for 12 weeks is efficacious and well‐tolerated for East Asian non‐cirrhotic HCV GT1b patients receiving hemodialysis. [ABSTRACT FROM AUTHOR]

Ancestry informative markers play an important role in medical genetics and forensic analyses. Several ancestry informative SNP panels have been developed and validated that can differentiate global populations into continental or major regional groups. These global panels have served as good first‐tier genetic markers; however, their performance in discriminating populations within regions appears unsatisfactory. To boost ancestry inference for regional populations, second‐tier panels with more refined discrimination power among subpopulations within each of the regions need to be developed. In East Asia, Han Chinese, Japanese, and Korean show highly similar externally visible characteristics and are genetically closely related. Reliable ancestry informative genetic markers appear invaluable in discriminating these populations. In the present study, we compiled a genome‐wide SNP dataset composing of 317,439 clean SNPs for a total of 1101 unrelated individuals from Han Chinese (817), Koreans (184), and Japanese (100). From this starting dataset, we developed a set of four nested ancestry informative SNP panels including 36, 59, 98, and 142 SNPs, respectively. The results of cross‐validation tests indicate that these panels can discriminate the Chinese Han, Japanese, and Korean populations with overall average accuracies ranging from 90% to 99%. In the further performance assessments, these panels also manifested high sensitivity and specificity. In combination with the first‐tier global panels, these second‐tier panels would contribute to medical genetics and forensic research in East Asia. [ABSTRACT FROM AUTHOR]

Copyright of Atmosphere -- Ocean (Taylor & Francis Ltd) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Non-linear behavioral links with atmospheric teleconnections were identified between the Indian Ocean Dipole (IOD) mode and seasonal precipitation over East Asia (EA) using statistical models. The analysis showed that the lower the lag time, the higher the correlation; more than a two-fold correlation for non-linear regression with a kernel density estimator than for the linear regression method. When the IOD peaked, a pattern of significant reductions in seasonal precipitation during the negative IOD period occurred throughout the Korean Peninsula (KP). The occurrence of the positive IOD was in line with the El Niño phenomenon and generated greater seasonal precipitation than only the positive IOD, which takes place from March to May. This change occurred more in the cold tongue El Niño than the warm pool El Niño, inducing much higher spring precipitation throughout the KP. When negative IODs and La Niña coincided, there was slightly greater precipitation from March to May compared to the sole occurrence of negative IODs. In positive (negative) IOD years, there was anti-cyclonic (cyclonic) circulation in the South China Sea (SCS), helping to transport moisture to EA. The composite precipitation anomalies in the positive (negative) IOD years show above (below) normal precipitation in southern China. In contrast, other parts of the EA experienced drier (humid) signals than normal years. In positive IOD years, the anti-cyclonic circulation strength of the Bay of Bengal and the SCS continued until autumn and spring of the following year. This shows possible remote connections between climate events related to the tropical Indian Ocean and variations in precipitation over EA. [ABSTRACT FROM AUTHOR]