Search

Your search keyword '"Jarolim, Petr"' showing total 2 results
Start Over Author "Jarolim, Petr" Region dominican republic
2 results on '"Jarolim, Petr"'

1. Using regional sero-epidemiology SARS-CoV-2 anti-S antibodies in the Dominican Republic to inform targeted public health response

Author

Martin, Beatris Mario, Restrepo, Angela Cadavid, Mayfield, Helen J, Paulino, Cecilia Then, De St Aubin, Micheal, Duke, William, Jarolim, Petr, Gutierrez, Emily Zielinski, Ramm, Ronald Skewes, Dumas, Devan, Garnier, Salome, Etienne, Marie Caroline, Pena, Farah, Abdalla, Gabriela, Lopez, Beatriz, de la Cruz, Lucia, Henriquez, Bernarda, Baldwin, Margaret, Sartorius, Benn, Kucharski, Adam, Nilles, Eric James, and Lau, Colleen L

Published
2023

2. Monitoring Temporal Changes in SARS-CoV-2 Spike Antibody Levels and Variant-Specific Risk for Infection, Dominican Republic, March 2021-August 2022.

Author

Nilles, Eric J., de St. Aubin, Michael, Dumas, Devan, Duke, William, Etienne, Marie Caroline, Abdalla, Gabriela, Jarolim, Petr, Oasan, Timothy, Garnier, Salome, Iihoshi, Naomi, Lopez, Beatriz, de la Cruz, Lucia, Puello, Yosanly Cornelio, Baldwin, Margaret, Roberts, Kathryn W., Peña, Farah, Durski, Kara, Sanchez, Isaac Miguel, Gunter, Sarah M., and Kneubehl, Alexander R.

Subjects
NUCLEIC acid amplification techniques, SARS-CoV-2, BIOMARKERS, ANTIBODY titer, IMMUNOGLOBULINS
Abstract

To assess changes in SARS-CoV-2 spike binding antibody prevalence in the Dominican Republic and implications for immunologic protection against variants of concern, we prospectively enrolled 2,300 patients with undifferentiated febrile illnesses in a study during March 2021-August 2022. We tested serum samples for spike antibodies and tested nasopharyngeal samples for acute SARS-CoV-2 infection using a reverse transcription PCR nucleic acid amplification test. Geometric mean spike antibody titers increased from 6.6 (95% CI 5.1-8.7) binding antibody units (BAU)/mL during March-June 2021 to 1,332 (95% CI 1,055-1,682) BAU/mL during May-August 2022. Multivariable binomial odds ratios for acute infection were 0.55 (95% CI 0.40-0.74), 0.38 (95% CI 0.27-0.55), and 0.27 (95% CI 0.18-0.40) for the second, third, and fourth versus the first anti-spike quartile; findings were similar by viral strain. Combining serologic and virologic screening might enable monitoring of discrete population immunologic markers and their implications for emergent variant transmission. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results