1. Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines.
- Author
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Chavez KJ, Feng X, Flanders JA, Rodriguez E, and Schroeder FC
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Breast Neoplasms drug therapy, Cell Line, Tumor, Dominican Republic, Humans, Lignans chemistry, Molecular Structure, Spiro Compounds chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Apoptosis drug effects, Guaiacum chemistry, Lignans isolation & purification, Lignans pharmacology, Spiro Compounds isolation & purification, Spiro Compounds pharmacology
- Abstract
We investigated the composition of extracts derived from Guaiacum spp. (Zygophyllaceae), a group of neotropical tree species with varied uses in Central and South American traditional medicine. Activity-guided fractionation of Guaiacum heartwood extracts led to the identification of four new spirocyclic lignans, named ramonanins A-D (1-4). The ramonanins exhibit cytotoxic activity against human breast cancer cell lines with an IC50 value of 18 μM and induce cell death via apoptotic mechanisms. The ramonanins are derived from four units of coniferyl alcohol and feature an unusual spirocyclic ring system.
- Published
- 2011
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