1. Epidemiological factors associated with ESBL- and non ESBL-producing E. coli causing urinary tract infection in general practice.
- Author
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Hertz FB, Schønning K, Rasmussen SC, Littauer P, Knudsen JD, Løbner-Olesen A, and Frimodt-Møller N
- Subjects
- Adult, Amdinocillin Pivoxil pharmacology, Amdinocillin Pivoxil therapeutic use, Anti-Bacterial Agents pharmacology, Case-Control Studies, Denmark epidemiology, Escherichia coli drug effects, Escherichia coli isolation & purification, Escherichia coli Infections drug therapy, Escherichia coli Infections microbiology, Female, General Practice, Humans, Male, Middle Aged, Patient Admission, Penicillin V pharmacology, Penicillin V therapeutic use, Retrospective Studies, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology, beta-Lactamases genetics, Anti-Bacterial Agents therapeutic use, Escherichia coli enzymology, Escherichia coli Infections epidemiology, Urinary Tract Infections epidemiology, beta-Lactam Resistance, beta-Lactamases biosynthesis
- Abstract
The purpose of the study was to evaluate how use of antibiotics precedes the presence of ESBL-producing E.coli in general practice. The authors performed a triple-case-control study where three case groups were individually compared to a single control group of uninfected individuals. Urine samples were prospectively collected and retrospective statistical analyses were done. This study included 98 cases with urinary tract infection (UTI) caused by ESBL-producing E. coli, 174 with antibiotic-resistant (non-ESBL) E. coli, 177 with susceptible E. coli and 200 with culture negative urine samples. Case groups had significantly higher use of antibiotics than the control group within 30 days before infection (p < 0.0001). The ESBL group had significantly more hospital admissions than the other case groups (p < 0.05). Hospital admission was an independent risk factor for community onset UTI by ESBL-producing E. coli. Exposure to antibiotics was a risk factor for UTI with E. coli, while prior antibiotic usage was not an indisputable predictor for infection with ESBL-producing E.coli in general practice.
- Published
- 2016
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