1. Iminolactones from Schizophyllum commune.
- Author
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Liu X, Frydenvang K, Liu H, Zhai L, Chen M, Olsen CE, and Christensen SB
- Subjects
- Alkaloids chemistry, Animals, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Denmark, Drug Screening Assays, Antitumor, Female, Fruiting Bodies, Fungal chemistry, Humans, Lactones chemistry, Lactones pharmacology, Male, Molecular Structure, Oxazines chemistry, Oxazines pharmacology, Phenylalanine metabolism, Tryptophan metabolism, Antineoplastic Agents isolation & purification, Lactones isolation & purification, Oxazines isolation & purification, Schizophyllum chemistry
- Abstract
Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.
- Published
- 2015
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