1. Molecular genetic characterisation of frontotemporal dementia on chromosome 3.
- Author
-
Ashworth A, Lloyd S, Brown J, Gydesen S, Sorensen SA, Brun A, Englund E, Humphreys C, Housman D, Badura M, Stanton V Jr, Taylor K, Cameron J, Munroe D, Johansson J, Rossor M, Fisher EM, and Collinge J
- Subjects
- Adult, Child, Cosmids genetics, DNA Fingerprinting, Dementia metabolism, Denmark, Disease Progression, Genetic Linkage genetics, Humans, Immunohistochemistry, Pedigree, Trinucleotide Repeats, Chromosomes, Human, Pair 3 physiology, Dementia genetics, Frontal Lobe metabolism, Temporal Lobe metabolism
- Abstract
We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion involvement. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence.
- Published
- 1999
- Full Text
- View/download PDF