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Abstract: Effects of randomness in fault rupture and in soil parameters (shear wave velocity and thickness of soil layers) and structural parameters of a R. C. portal frame ((shear stiffness and mass density) on the seismic response of the portal frame in the Delhi region has been studied. Bedrock outcrop ground motions have been generated for three earthquakes of magnitudes (MW of 7.5, 8.0 and 8.5) using stochastic finite fault model. One dimensional equivalent linear ground response analyses that takes into account the variations in soil parameters have been carried out at three typical sites. It is seen that randomness in fault rupture contributes predominantly to the variability in the response. It is further seen that the effect of randomness in soil and structural parameters on the seismic response may also be significant. [Copyright &y& Elsevier]