1. Candida auris in Dog Ears.
- Author
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Yadav, Anamika, Wang, Yue, Jain, Kusum, Panwar, Vijay Amrit Raj, Kaur, Hardeep, Kasana, Vikas, Xu, Jianping, and Chowdhary, Anuradha
- Subjects
EAR canal ,CANDIDA ,NUCLEOTIDE sequencing ,OTITIS externa ,MICROBIAL cultures ,EAR ,ANTIFUNGAL agents - Abstract
Candida auris is an emerging global public health threat and is resistant to most antifungal agents. Though fungi are significant pathogens for animals, the role of C. auris in animal health remains unexplored. Here, we analysed the microbial cultures of skin and ear swabs of 87 dogs in Delhi and performed fungal meta-barcode sequencing of ear and skin samples of 7 dogs with confirmed otitis externa (OE). Overall, 4.5% of dogs (4/87) with chronic skin infections contained evidence of C. auris in their ear canal (n = 3) and on their skin surface (n = 1). Of the three OE dogs with C. auris infection/colonisation, a diversity of fungi was observed, and their meta-barcode ITS sequence reads for C. auris ranged from 0.06% to 0.67%. Whole-genome sequencing of six C. auris strains obtained in culture from two dogs showed relatedness with Clade I clinical strains. The report highlights the isolation of C. auris from an animal source; however, the routes of transmission of this yeast to dogs and the clinical significance of transmission between dogs and humans remain to be investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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