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1. Pro- and anti-fibrotic effects of TGF-β in scleroderma.

Author

Sgonc, R. and Wick, G.

Subjects
*SCLERODERMA (Disease), *COLLAGEN diseases, *SYSTEMIC scleroderma, *TRANSFORMING growth factors, *IMMUNOMODULATORS
Abstract

The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-β1) and anti-fibrotic (TGF-β2 and -β3) TGF-β isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition. [ABSTRACT FROM PUBLISHER]

Published
2008
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