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Introduction: Adverse reactions to antimicrobials in Cuba have taken place since 2003 to date, the first in the report of adverse reactions in general, as well as serious and fatal reactions, on the skin and schedules are the systems more affected. This research aimed to characterize the antibacterial dermatologic toxicities reported by the national coordinating pharmacovigilance unit from 2007 to 2009. Method: An observational study of Pharmacovigilance, descriptive and transversal using Spontaneous Reporting of Suspected Adverse Reaction database and the Cuban system of pharmacovigilance. Reports were analyzed for antibacterial dermatologic toxicities reported from 2007 through 2009, the primary endpoint was the dermatologic adverse effect reported. Results: A total of 3006 suspected adverse reactions to skin. Predominated in females (60.2%) and in adults, 53.7%. The antibacterial associated with increased number of notifications were 18.5% RL penicillin, amoxicillin, cephalexin, 17.3% and 9.7%. Dermatological adverse events predominated were rash and urticaria. Moderate adverse effects predominated (64.4%), 87.5% were probable and 81.8% common. Conclusions: Adverse dermatologic antibacterial dominated by females and in adults. RL Penicillin was the drug most associated with adverse reactions. Moderate adverse reactions, probable and common were the more frequent in the study. [ABSTRACT FROM AUTHOR]

Microorganism resistance to antibacterial drugs is a health problem throughout the world, for that reason it is necessary to find new therapeutic alternatives from natural sources. Propoaromiel (PHO) is a mixture of honey, propolis and essential oils. The objective of this work was to evaluate the in vitro antibacterial activity of PHO against 239 microorganisms isolated from clinical samples: S. aureus (N= 53); S. pneumoniae (N = 37) and S. B. hemoliticcus (N = 49) N. meningitidis (N= 42); M. catarrhalis (N=5). P.aeruginosa (N= 37); E. coli (N=5); Salmonella sp (N=8); Proteus sp (N=2) and Hafnia (N=1). The in vitro activity was tested by minimum inhibitory concentration (MIC) using the agar dilution method according to the National Committee for Clinical Laboratory Standards Guidelines (NCCLS). All the microorganism suspensions were adjusted to a 0.5 MacFarland standard. To determine MIC, PHO two-fold dilutions were prepared ranging from 5.07 to 650 mg/ml. Muller Hinton Agar plates containing 5% sheep blood were used for bacterial growth. The plates were incubated 24 hours at 37°C in 5% CO2 humid atmosphere. N. meningitidis and S. pneumoniae strains showed the highest sensitivity (MIC90 30,4mg/ml). On the other hand, S.aureus (MIC90 243,7mg/ml) and Gram negative bacilli (MIC90 243.7mg/ml) were more resistant to PHO activity. PHO displayed antibacterial activity against all the strains studied. [ABSTRACT FROM AUTHOR]