1. Obstetrical and gynecological complications in fragile X carriers: a multicenter study.
- Author
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Schwartz CE, Dean J, Howard-Peebles PN, Bugge M, Mikkelsen M, Tommerup N, Hull C, Hagerman R, Holden JJ, and Stevenson RE
- Subjects
- Abortion, Spontaneous etiology, Adult, Colorado, DNA Mutational Analysis, Denmark, Female, Fragile X Syndrome genetics, Humans, Menstruation Disturbances genetics, Mutation, Ontario, Oogonia physiology, Pregnancy, Repetitive Sequences, Nucleic Acid, Risk Assessment, South Carolina, Virginia, Fragile X Syndrome complications, Heterozygote, Menopause, Premature genetics, Menstruation Disturbances etiology
- Abstract
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
- Published
- 1994
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