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Cardiovascular diseases (CVD) are the leading cause of death in the world, and they are considered a serious public health problem in Colombia. The main goal of this study was to analyze CVD mortality spatially and temporarily in the Pacific region of Colombia during the 2002-2015 period, and its association with some municipal socio-economic indicators using spatial statistical analysis techniques. It involved a descriptive-ecological study in the 177 municipalities of the Pacific region that used CVD mortality data, under codes I00-I99 of the International Classification of Diseases (ICD-10), and seven municipal socio-economic indicators. The analysis included the calculation of crude and standardized mortality rates, according to sex, for CVD and its main causes, and modeling of CVD death counts using Bayesian hierarchical models. During the 2002-2015 period, standardized rates of CVD mortality showed a downward trend in men (129.0 to 119.3) and in women (129.0 to 110.0), the main causes of death being ischemic heart diseases, followed by cerebrovascular diseases. In general, the risk of CVD mortality was higher in the less economically and socially privileged municipalities.