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Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

With the global increase in population and urban expansion, the simultaneous rise of social demand and degradation of ecosystems is omnipresent, especially in the urban agglomerations of China. In order to manage environmental problems and match ecosystem supply and social demand, these urban agglomerations promoted regional socio-ecological integration but ignored differential city management during the process of integration. Therefore, it is necessary to design a general framework linking ecosystem supply and social demand to differential city management. In addition, in previous studies, ecosystem services supply-demand amount (mis)match assessment was emphasized, but ecosystem services supply-demand type (mis)match assessment was ignored, which may lead to biased decisions. To deal with these problems, this study presented a general ecosystem services framework with six core steps for differential city management and developed a double-indices (amount and type) method to identify ecosystem services supply-demand (mis)matches in an urban agglomeration. This framework and the double-indices method were applied in the case study of the Yangtze River Delta Urban Agglomeration. Ecosystem supply-demand amount and type (mis)match levels and spatial pattern of twenty-six cities were identified. Twenty-six cities in the YRDUA were classified into five kinds of cities with different levels of ES supply-demand (mis)matches for RS, three kinds of cities for PS, and four kinds of cities for CS. Differential city management strategies were designed. Despite its limitations, this study can be a reference to giving insights into ES supply-demand (mis)match assessment and management.

On March 1, 2012, the Chinese government implemented the Administrative Measures on Heatstroke Prevention (AMHP2012) to combat the occupational health impacts of extreme heat, and reducing occupational injury was one of the main purposes. This study aimed at quantifying the intervention effects of the AMHP2012 on extreme heat-related occupational injuries and subsequent insurance payouts in Guangzhou, China. Data on occupational injuries and insurance payouts were collected from March 1, 2011, to February 28, 2013, from the occupational injury insurance system of Guangzhou. A quasi-experimental design with before-after control was adopted. Interrupted time series analysis was performed to quantify the change of occupational injuries and insurance payouts after policy implementation. The distributed lag non-linear model was used to explore whether injury claims and insurance payouts due to extreme heat decreased. A total of 9851 injury claims were included in the analysis. After policy implementation, the risk of occupational injuries and insurance payouts decreased by 13% (RR = 0.87, 95%CI: 0.75, 0.99) and 24% (RR = 0.76, 95% CI: 0.58, 0.94), respectively. The attributable fraction of extreme heat-related occupational injuries decreased from 3.17% (95%eCI: 1.35, 4.69) to 1.52% (95%eCI: -0.36, 3.15), which contributed to 0.86 million USD reduction of insurance payouts. Both males and females, low-educated, young and middle-aged workers, workers at small or medium-sized enterprises, engaging in manufacturing, and with both minor and severe injuries were apparently associated with decreased rates of extreme heat-related occupational injuries. The AMHP2012 policy contributed to the reduction of extreme heat-related occupational injuries and insurance payouts in Guangzhou, China, and this research provided novel evidence for decision-makers to better understand the necessity of implementing health protection policies among laborers under climate change., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2020 Elsevier Inc. All rights reserved.)