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Objective: To analyze the epidemiological, occupational characteristics and clinical manifestations of reported cases of occupational brucellosis (OB) in Hulunbeier city from 2008 to 2018, so as to provide scientific basis for the formulation of prevention and control measures for occupational brucellosis. Methods: China Information System for Disease Control and Prevention had exported the network report data of "occupational diseases and occupational health information monitoring" from January 1, 2008 to December 31, 2018 and had created the database; The epidemiological characteristics, clinical manifestations and laboratory examinations of OB were analyzed. Results: There were 262 OB cases in Hulunbuir from 2008 to 2018, including male in 235 cases, female in 27 cases. The most age was 41-50 years old (97 cases, 37%) . The length of service was concentrated in 0-10 years (146 cases, 55.7%) ; in the time distribution, the incidence in January was mostly (87 cases, 33.2%) . The industry distribution of veterinarians was the most (139 cases, 53.1%) , followed by epidemic prevention workers (58 cases, 22.1%) . The regional distribution is mainly concentrated in Ergun city (51 cases, 19.5%) , Hailar District (43 cases, 16.4%) , Orogen Autonomous Banner (40 cases, 15.3%) . The main clinical features were asthenia (194 cases, 74.0%) , hyperhidrosis (144 cases, 55.0%) , joint and muscle pain (156 cases, 59.5%) . The course of disease was mostly chronic (181 cases, 69.1%) . Conclusion: The cases of OB in Hulunbuir city are distributed in the developed areas of animal husbandry, and the incidence months are concentrated. Veterinarians are the key high-risk occupational groups.