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Objective: Two large randomized trials of patients with differentiated thyroid cancer (DTC) reported recently (HiLo and ESTIMABL1) found that the recurrence rate among patients who underwent 1.1 GBq radioactive iodine (RAI) ablation was not higher than that of patients who underwent 3.7 GBq radioactive iodine (RAI) ablation. However, no similar studies have been conducted in China. We aimed to report clinical outcomes in Chinese patients with low/intermediate risk of recurrence DTC after long‐term follow‐up, and evaluate the risk factors that influence the presence or absence of incomplete response at the final follow‐up. Design: A long‐term follow‐up of a Chinese randomized clinical trial (October 2014 and February 2021) was conducted. Patients: A total of 506 DTC patients at low/intermediate risk of recurrence who were randomized into two groups to receive 1.1 (n = 251) or 3.7 GBq (n = 255) RAI ablation following thyroid hormone withdrawal were followed on levothyroxine treatment for a median of 4.5 years (range: 1.6−6.3). Measurements: Suppressed serum thyroglobulin (Tg) and anti‐thyroglobulin antibody (TgAb) levels were determined, and neck ultrasonography was performed. Results: At the final follow‐up, 499 (98.6%) patients showed an excellent response. The other seven patients (two patients underwent 1.1 GBq and five patients underwent 3.7 GBq RAI ablation, respectively) showed either structural incomplete response (lymph node metastasis, n = 1), biochemical incomplete response (increased serum Tg ≥ 1 ng/ml, or increased positive TgAb levels, n = 5), or indeterminate response (stable positive TgAb levels, n = 1). The risk of incomplete response at the final follow‐up was significantly increased in patients with stimulated serum Tg ≥ 10 ng/ml at ablation (p =.003) and in patients with unsuccessful ablation (p =.008). Conclusion: Our findings indicated that there was no difference in the long‐term outcomes with RAI ablation using either 1.1 or 3.7 GBq in patients with low/intermediate risk of recurrence DTC, and 1.1 GBq RAI might be suitable for patients who are recommended for ablation. [ABSTRACT FROM AUTHOR]