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The stability of rural credit cooperatives is closely linked to regional economic development in China's vast rural areas. This study aims to investigate how rural credit cooperatives in China can enhance their stability and achieve high-quality development using panel data from 87 county rural credit cooperatives in Shaanxi Province from 2008 to 2016. The Cov-AHP is employed to build an evaluation system and the effect of inclusive finance on the risk-taking capacity of rural credit cooperatives is analysed using a fixed effects model. Results demonstrate that inclusive finance can improve the risk-taking capacity of rural credit cooperatives and enhance their stability. This effect is more significant for rural credit cooperatives with a larger share of corporate shares, although property rights reform and the launch of community banks may weaken this effect. This study recommends vigorously promoting the development of inclusive finance, improving the operational mode of rural commercial banks, strengthening the corporate governance system of rural credit cooperatives, and enhancing the level of financial services for agriculture, rural areas, and farmers. These implications are important for promoting the further reform of rural credit cooperatives, especially in developing countries. [ABSTRACT FROM AUTHOR]

Aim: To construct a health empowerment framework for the Chinese older people with chronic conditions. Design: A Strussian grounded theory design was selected to generate the theoretical framework. Methods: Data were collected from 53 community‐dwelling older people with chronic conditions in China between November 2017 and August 2019, via semi‐structured interviews and with participating observation. The constant comparative method identified the key categories. Results: 'Responsibility endowing power', the health empowerment core theme, was defined as initiating, performing and realizing responsibility towards health through the interaction between the self, family and society. The framework enriches the meaning of health empowerment, changing older people's nursing practice. [ABSTRACT FROM AUTHOR]

Purpose: This paper according to the logic of the "digital access divide--digital capability divide--digital outcome divide" aims to systematically discuss the impact of the digital divide on individual happiness in China, accounting for the variations that exist across different groups, as well as the corresponding mechanisms. Design/methodology/approach: This paper presents cross-sectional analyses of the relationship between the digital divide and individual happiness in China. The analyses are based on data from the Chinese General Social Survey 2017, which academic institutions run on the Chinese Mainland. This database contains information on respondents' Internet access, skills and consequences of use, which can measure the digital divide of Chinese individuals at three levels. Findings: First, individual happiness declined when they experienced the digital access divide in China. For the digital capability divide, the lower the usage skills, the more individual happiness declined. When analyzing the digital outcome divide, the greater the negative consequences, the more individual happiness declined. Second, the impacts of digital access, capability and outcome divide vary according to age, gender, education degrees, hukou, region and sub-dimensions. Third, the digital access and capability divide reduce individuals' happiness by lowering their self-rated social and economic status, whereas the digital outcome divide reduce individual happiness by lowering their fairness perception and social trust. Originality/value: The authors believe that this is the first study to examine the impact and its variations among different groups of the three-level digital divide on individual happiness, as well as its mechanisms. [ABSTRACT FROM AUTHOR]

Background: Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic basis of eRNA expression may elucidate the molecular mechanisms underlying cancers. Methods: Initially, a comprehensive analysis of eRNA quantitative trait loci (eRNAQTLs) was performed in The Cancer Genome Atlas (TCGA), and functional features were characterized using multi-omics data. To establish the first eRNAQTL profiles for colorectal cancer (CRC) in China, epigenomic data were used to define active enhancers, which were subsequently integrated with transcription and genotyping data from 154 paired CRC samples. Finally, large-scale case-control studies (34,585 cases and 69,544 controls) were conducted along with multipronged experiments to investigate the potential mechanisms by which candidate eRNAQTLs affect CRC risk. Results: A total of 300,112 eRNAQTLs were identified across 30 different cancer types, which exert their influence on eRNA transcription by modulating chromatin status, binding affinity to transcription factors and RNA-binding proteins. These eRNAQTLs were found to be significantly enriched in cancer risk loci, explaining a substantial proportion of cancer heritability. Additionally, tumor-specific eRNAQTLs exhibited high responsiveness to the development of cancer. Moreover, the target genes of these eRNAs were associated with dysregulated signaling pathways and immune cell infiltration in cancer, highlighting their potential as therapeutic targets. Furthermore, multiple ethnic population studies have confirmed that an eRNAQTL rs3094296-T variant decreases the risk of CRC in populations from China (OR = 0.91, 95%CI 0.88–0.95, P = 2.92 × 10−7) and Europe (OR = 0.92, 95%CI 0.88–0.95, P = 4.61 × 10−6). Mechanistically, rs3094296 had an allele-specific effect on the transcription of the eRNA ENSR00000155786, which functioned as a transcriptional activator promoting the expression of its target gene SENP7. These two genes synergistically suppressed tumor cell proliferation. Our curated list of variants, genes, and drugs has been made available in CancereRNAQTL (http://canernaqtl.whu.edu.cn/#/) to serve as an informative resource for advancing this field. Conclusion: Our findings underscore the significance of eRNAQTLs in transcriptional regulation and disease heritability, pinpointing the potential of eRNA-based therapeutic strategies in cancers. [ABSTRACT FROM AUTHOR]

Large-scale management is the key to realizing long-term agricultural growth in smallholder countries. Land-scale management and service-scale management are two forms of agricultural large-scale management. The former is committed to changing the small-scale management pattern, but the latter tends to maintain it. There has been a lack of discussion and controversy about the relationship between the two. From the perspective of market maturity, this paper explores whether the two are complementary or mutually exclusive and how their complementary or mutually exclusive relationship affects agricultural green productivity. The results show the following: Land-scale management and service-scale management are complementary, not superficially contradictory. The benign interaction between the two has a consistent improvement effect on green productivity in both the short and long term, which has spatial spillovers appearing in the long term. The reasons are as follows: The farmland rental market can reverse the inhibitory effect of the current low-maturity outsourcing services market on green productivity. The outsourcing services market can delay the arrival of the inflection point beyond which expansion of farmland rental transactions reduces green productivity, and amplify the positive effect of farmland rental on it. Although the degree of benign interaction between the two forms of large-scale management has gradually increased in recent years, it is still low overall. Agricultural large-scale management in China is still in the stage driven by land-scale management. Smallholder countries such as China need not worry prematurely about which large-scale management path to take, and they should treat both forms of large-scale management with an equal perspective to accelerate the high-level interaction between them. [ABSTRACT FROM AUTHOR]

Problem definition: Content promotion policies are crucial for online content platforms to improve content consumption and user engagement. However, traditional promotion policies generally neglect the diffusion effect within a crowd of users. In this paper, we study the candidate generation and promotion optimization (CGPO) problem for an online content platform, emphasizing the incorporation of the diffusion effect. Methodology/results: We propose a diffusion model that incorporates platform promotion decisions to characterize the adoption process of online content. Based on this diffusion model, we formulate the CGPO problem as a mixed-integer program with nonconvex and nonlinear constraints, which is proved to be NP-hard. Additionally, we investigate methods for estimating the diffusion model parameters using available online platform data and introduce novel double ordinary least squares (D-OLS) estimators. We prove the submodularity of the objective function for the CGPO problem, which enables us to find an efficient (1−1/e) -approximation greedy solution. Furthermore, we demonstrate that the D-OLS estimators are consistent and have smaller asymptotic variances than traditional ordinary least squares estimators. By utilizing real data from a large-scale video-sharing platform, we show that our diffusion model effectively characterizes the adoption process of online content. Compared with the policy implemented on the platform, our proposed promotion policy increases total adoptions by 49.90%. Managerial implications: Our research highlights the essential role of diffusion in online content and provides actionable insights for online content platforms to optimize their content promotion policies by leveraging our diffusion model. Funding: R. Zhang is grateful for the financial support from the Hong Kong Research Grants Council General Research Fund [Grants 14502722 and 14504123] and the National Natural Science Foundation of China [Grant 72293560/72293565]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0172. [ABSTRACT FROM AUTHOR]

Bilobalide has shown strong anti-inflammatory activity. Colorectal cancer (CRC) is closely associated with inflammation. However, no studies have reported on the use of bilobalide for treating CRC. This study aims to evaluate the effect of bilobalide on CRC prevention. Enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, and immunofluorescence showed that bilobalide significantly inhibits the M2 polarization of macrophages dependent on phorbol 12-myristate 13-acetate (PMA) and interleukin-4 (IL-4). Analysis of signaling pathways showed that the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and signal transducer and activator of transcription 3 (STAT3) was regulated. In particular, human CRC organoids were established. Western blotting, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL), and analysis of cell viability and morphology further supported the hypothesis that the anti-CRC effects of bilobalide could be explained by its ability to suppress M2 macrophage polarization and promote M1 transformation. C57BL/6 mice treated with azoxymethane (AOM)/dextran sodium sulfate (DSS) were divided into three groups, i.e., control, AOM/DSS, low (2.5 mg/kg), and high (5 mg/kg). High-dose bilobalide markedly inhibited the progression of CRC, as evidenced by the increased body weight, decrease in disease activity index (DAI) death rate, and alleviation of colon length reduction and tumorigenesis. According to the in vivo results, reduced levels of inflammatory cytokines in the serum included tumor necrosis factor (TNF-α), IL-6, IL-1β, and IL-10. Bilobalide reduced oxidative stress indices, lipid peroxide (LPO), and malondialdehyde (MDA) and increased reduced glutathione (GSH). In addition, the expression of proliferating cell nuclear antigen (PCNA), Ki67, cellular Myc (c-Myc), and CD206 was downregulated in the drug-treated groups, as confirmed by the immunohistochemical staining. Collectively, these results indicated that bilobalide administration improve experimental CRC by inhibiting M2 macrophage polarization and oxidative stress. Thus, bilobalide may prevent CRC and serve as a potential therapeutic target for CRC. [ABSTRACT FROM AUTHOR]

This paper explores the knowledge network structure of foreign research literature by applying the qualitative comparative analysis (QCA) method to the field of information science and library science (ISLS) from the perspective of the cocitation of social network actors such as authors, institutions, countries, and literature, and it further reveals the future application trends of this method. [Method/process] Based on 86 journals in the ISLS field that were downloaded from the Web of Science using the QCA method, the social network analysis (SNA) method and the visual analysis tool Gephi are used to analyse the author cooperation network, the research institution cooperation network, the national cooperation network, the cocitation network, the cutting-edge trends, etc., of journal papers. The analysis shows that the QCA method covers a wide range within the field of ISLS, but the research topics involved in this field are not concentrated, and the author cooperation network has scale-free characteristics. The application of the QCA method is still dominant in European and American countries, and China, the USA, and Italy all play key roles in the national cooperation network. Finally, the institutional cooperation network has certain small group attributes. [ABSTRACT FROM AUTHOR]

Mongolian willow (Salix linearistipularis) is a naturally occurring woody dioecious plant in the saline soils of north-eastern China, which has a high tolerance to alkaline salts. Although transcriptomics studies have identified a large number of salinity-responsive genes, the mechanism of salt tolerance in Mongolian willow is not clear. Here, we found that in response to Na2CO3 stress, Mongolian willow regulates osmotic homeostasis by accumulating proline and soluble sugars and scavenges reactive oxygen species (ROS) by antioxidant enzymes and non-enzymatic antioxidants. Our quantitative proteomics study identified 154 salt-sensitive proteins mainly involved in maintaining the stability of the photosynthetic system and ROS homeostasis to cope with Na2CO3 stress. Among them, Na2CO3-induced rubredoxin (RUB) was predicted to be associated with 122 proteins for the modulation of these processes. The chloroplast-localized S. linearistipularis rubredoxin (SlRUB) was highly expressed in leaves and was significantly induced under Na2CO3 stress. Phenotypic analysis of overexpression, mutation and complementation materials of RUB in Arabidopsis suggests that SlRUB is critical for the regulation of photosynthesis, ROS scavenging and other metabolisms in the seedlings of Mongolian willow to cope with Na2CO3 stress. This provides more clues to better understand the alkali-responsive mechanism and RUB functions in the woody Mongolian willow. [ABSTRACT FROM AUTHOR]

Brownfields have been receiving significant attention all over the world because of their potential threats to the environment and public health. However, a funding shortage constitutes the main obstacle to the brownfield remediation (BR). In China, to ease financial dilemmas, the governments seek collaborations with private-sector companies, i.e., the Public Private Partnership (PPP) mode. Despite all the benefits, BR and PPP contain high risks, making stakeholders extremely cautious about investing in such projects. To support the decision-making process of the public and private parties, this paper designs a comprehensive approach to evaluate the risks of BR PPP projects in China. In more detail, several commonly used risk methods, such as TOPSIS, GRE, and FSE, are employed to construct a combined risk evaluation process, which applies multiple combined evaluation techniques to iteratively integrate individual results from those methods until a valid common result is achieved. To show the practical implementation procedure of the proposed combined approach, a hypothetical case study is performed to assess the risks of seven BR PPP projects. The analytical process also verifies that the consistency and reliability of the risk evaluation result can be achieved effectively and efficiently by jointly deploying multiple risk methods through combined techniques. The proposed decision framework facilitates a novel research idea in evaluating complicated risk situations, and can be applied to other similar scenarios where uncertainties and inconsistencies are inevitable. [ABSTRACT FROM AUTHOR]

Rebuilding soil healthy microbiota is very important for preventing bacterial wilt. A 3-year-long field trial was conducted in China as follows: T1 (conventional fertilization), T2 (T1 + liming), T3 (T1 + bioorganic fertilizer), and T4 (T2 + bioorganic fertilizer). Fluorescence quantitative PCR and high-throughput sequencing were employed to study the dynamics of Ralstonia solanacearum population, microbial community, and network organizations between bacteria and quality-related variables. After 3 years of bioremediation, the control efficacy of tobacco bacterial wilt reached 61.30% and the occurrence delayed by approximately 40 days in T4, which had the highest tobacco yield and output value. The pathogen population of T4 remained below 106 copies/g soil during the entire growth period. Role-shifts prevailed among the network members. Microbes were unipathically associated with variables in T1 but multiplex in T4. In conclusion, soil bioremediation rebuilds a healthy soil microbiota and forms a more interactive and relevant micro-system, thus effectively controlling tobacco bacterial wilt. Key points: • This is the first time to effectively bio-control tobacco bacterial wilt in practical production in China, as well as to high-efficiently use the organic waste, thus promoting the organic cycling of the environment. • Soil bioremediation can effectively control soil-borne disease by rebuilding soil healthy microbiota and reducing abundance of pathogenic bacteria, thereby to prevent the soil borne disease occurrence. • After the soil remediated, microbes associated with soil and tobacco characteristics changed from unipathical to multiplex, and the keystone species play different roles compared with the original soil, thus signifying the complexity of multi-species interactions and achieving a closely relevant micro-system, which was ecologically meaningful to the environment. [ABSTRACT FROM AUTHOR]

Background and Purpose The management of older aneurysmal subarachnoid haemorrhage (aSAH) cases is a clinical challenge. This study aimed to analyse the survival and functional outcomes in older aSAH patients (age ≥ 70 years) to provide evidence for making treatment decisions for such patients. Methods We performed a 2-year follow-up analysis of the Chinese Multi-Centre Cerebral Aneurysm Database for older patients suffering from aSAH from 2017 to 2020. A survival analysis was used to investigate the mean survival and hazard ratios for death. Binary logarithmic regression was performed to investigate the odds ratio for independent survival and dependent survival. Results A total of 1,136 consecutive older patients with aSAH were assessed in this study, and 944 patients (83.1%) were followed up. The overall mean survival was 37.79 ± 1.04 months. A total of 380 (40.25%) patients died within 2 years after aSAH. In survival analysis, the predictors of mortality were older age, intracerebral haemorrhage (ICH) history, Hunt-Hess (H-H) grade, World Federation of Neurosurgical Societies (WFNS) grade and operative treatment decreased the risk of mortality compared to conservative treatment. In binary logarithmic regression, the predictors of dependent survival were hypertension, diabetes, WFNS grade. Conclusions The risk for 2-year mortality after aSAH increases markedly with older age, ICH history, H-H grade and WFNS grade. Risk factors for 2-year dependent survival were associated with hypertension, diabetes and WFNS grade in older patients with aSAH. Operative treatment markedly decreased mortality but did not significantly decrease the morbidity of dependent survival compared to conservative treatment. [ABSTRACT FROM AUTHOR]

The carbon emission trading market (carbon market) is an important policy tool for China to achieve the goal of "carbon peak and carbon neutrality" through market mechanism. This paper uses panel data of 30 provinces in China from 2005 to 2019 to examine the emission reduction effect (ERE) of China's carbon market pilots using multi-period Difference-in-Differences (DID)method, and then analyzes the factors influencing ERE and the economic impact of carbon market. According to the Bacon decomposition and a series of robustness tests, the results reveal that China's carbon market pilots have significant ERE. Both the expansion of the carbon market scale and the improvement of market activity level can significantly boost the carbon market's ERE. Meanwhile, the establishment of carbon market has no negative impact on the economic growth. Therefore, we propose to accelerate the construction of the national carbon market, incorporating more industries in a systematic manner, expand the scale of the carbon market, steadily promote the innovation of carbon financial instruments, improve the activity of the carbon market, so as to promote the transformation of China's green and low-carbon economy and achieve the emission reduction target as scheduled. [ABSTRACT FROM AUTHOR]

Aquatic life criteria (ALC) serve as the scientific foundation for establishing water quality standards, and in China, significant strides have been made in the development of freshwater ALC. This comprehensive review traces the evolution of China's WQC, focusing on the methodological advancements and challenges in priority pollutants selection, test organism screening, and standardized ecotoxicity testing protocols. It also provides a critical evaluation of quality assurance measures, data validation techniques, and minimum data requirements essential for ALC assessments. The paper highlights China's technical guidelines for deriving ALC, and reviews the published values for typical pollutants, assessing their impact on environmental quality standards. Emerging trends and future research avenues are discussed, including the incorporation of molecular toxicology data and the development of predictive models for pollutant toxicity. The review concludes by advocating for a tiered WQC system that accommodates China's diverse ecological regions, thereby offering a robust scientific basis for enhanced water quality management. [ABSTRACT FROM AUTHOR]

The Northwest Indian Ocean is a key fishing ground for China's pelagic fisheries, with the purpleback flying squid being a significant target. This study uses commercial fishing logs of the Indian Ocean between 2015 and 2021, alongside pelagic seawater temperature and its vertical temperature difference within the 0–200 m depth range, to construct generalized additive models (GAMs) and gradient boosting tree models (GBTs). These two models are evaluated using cross-validation to assess their ability to predict the distribution of purpleback flying squid. The findings show that factors like year, latitude, longitude, and month significantly influence the distribution of purpleback flying squid, while surface water temperature, 200 m water temperature, and the 150–200 m water layer temperature difference also play a role in the GBT model. Similar factors also take effects in the GAM. Comparing the two models, both GAM and GBT align with reality in predicting purpleback flying squid resource distribution, but the precision indices of GBT model outperform those of the GAM. The predicted distribution for 2021 by GBT also has a higher overlap with the actual fishing ground than that by GAM, indicating GBT's superior forecasting ability for the purpleback flying squid fishing ground in the Northwest Indian Ocean. [ABSTRACT FROM AUTHOR]

Zhang, S.; Tang, F.; Fan, W.; Yang, S.; Zhu, W.; Zhang, H., and Cui, X., 2023. Analysis of hauling net hours for Gazami crab (Portunus trituberculatus) gillnets based on the Beidou vessel monitoring system (BDVMS). Journal of Coastal Research, 39(4), 663–674. Charlotte (North Carolina), ISSN 0749-0208. Gillnets are among the most widely used fishing gear in the world, and there are nearly 97 thousand gillnetters in China's offshore. With the decline of resource fisheries, the fishing quota has remained a topic of concern for the world's fishing nations. At the beginning of 2017, the Ministry of Agriculture and Rural Affairs of the People's Republic of China implemented the total management of marine fishery resources and began to launch the quota fishing experiment. The vessel monitoring system (VMS) provides a new data source for fisheries research. It is a new attempt to estimate fishing yield from VMS. Refined fishing intensity can be obtained through calculation of hauling time or net length. In China, the shipboard Beidou satellite navigation system terminal was installed on well-equipped fishing vessels. It sends vessel identification and location information at three minute intervals and with 10 m spatial resolution. In this paper, the speed threshold was used to consider the hauling duration of the net. The hauling nets' hours were calculated to estimate the catch rate with the hours. The speed thresholds of the 56 vessels were from 1.7 to 2.4 m/s. The hauling duration in hour of the vessels were distributed throughout eight fishing grounds in 2017. Hauling duration was divided into 0.01° × 0.01° grids based on coordinate locations. The average hauling duration of the nets was 1.7 h, and the maximum value was 41.5 h. There were approximately 514 thousand net hauling points, and the catch weight of the swimming crab (Portunus trituberculatus) was calculated to be approximately 4.7 million kg in 2017 based on the hauling duration data. [ABSTRACT FROM AUTHOR]

To analyze the diversity in endoscopic manifestations of Meckel's diverticulum (MD) in adults by using balloon-assisted enteroscopy (BAE) and supply more information on the application of BAE. A retrospective study was carried out on adult patients diagnosed with MD by BAE in two tertiary general hospitals in China, from May 2007 to September 2021. The patients were divided into a small bowel bleeding (SBB) group and a control group according to their main symptoms. Clinical charts and endoscopic images were reviewed, analyzed, and summarized. Single diverticulum in the ileum and double-lumen sign were observed in all patients. The SBB group consisted of 51 patients, among which 35 cases of ulcerative lesions, 9 cases of erosive lesions, 9 cases of active bleeding/blood clots, and 4 cases of lumps inside the diverticulum were observed respectively. Majority of ulcerative lesions were inside the diverticulum (23/35). A circumferential stricture inside the diverticulum was discovered in 11 cases, and ulcerative lesions tended to occur at this structure (10/11). In the control group consisting of 15 patients, 1 case of erosive lesions at the orifice edge was observed. The percentage of patients with MD-associated ulcerative lesions was significantly higher in the SBB group than that in the control group (p < 0.001). The endoscopic manifestations of MD in adults are extraordinarily complex and connected with the patients' primary symptoms. The internal features of MD should be regarded as crucial observational objectives in adult patients. [ABSTRACT FROM AUTHOR]

Sheep are highly susceptible to Toxoplasma gondii, and miscarriage is the main clinical feature. This study investigated 227 sheep samples (210 myocardial tissues from slaughterhouses, 6 ewe serum samples, 3 aborted fetuses, and 8 dead lambs from veterinary clinics) from central China for T. gondii infection. Antibodies against T. gondii were detected using the modified agglutination test (MAT). PCR was performed to detect T. gondii DNA in the tissue samples. The results showed that four samples were seropositive (MAT titer ≥ 1:100), with a seroprevalence of 1.8% (4/227). The seropositive samples included two myocardial samples from a slaughterhouse, one ewe and its aborted fetus from a veterinary clinic. The results revealed that 7 out of 207 (3.4%) sheep tissue samples were PCR-positive, including two myocardial tissue samples from slaughterhouses, three aborted fetuses, and two lambs from veterinary clinics. Toxoplasma gondii vertical transmission had occurred in two of three pairs of ewes and her pups. One viable T. gondii strain (TgSheepCHn14) was isolated from the myocardial tissues of sheep from a slaughterhouse. Tachyzoites were obtained from cell cultures at 70 days following seeding in the brains and lungs of mice. This strain was non-lethal to Swiss mice. The number of parasite brain cysts in mice decreased with time post-infection (p < 0.05). Overall, the prevalence of T. gondii in the sheep samples was low. Although the samples were scattered, and not from planned collections, the current study detected T. gondii antibodies and DNA in aborted fetuses, indicating that vertical transmission could occur and maintain the parasites in sheep herds without exogenous infection. [ABSTRACT FROM AUTHOR]

To systematically analyze the spatiotemporal heterogeneity, diurnal variation characteristics, and influencing factors of karst cave microclimate environments in Mahuang Cave, a cave in the Shuanghe Cave National Geological Park in Guizhou Province, China, was investigated. Monthly monitoring of meteorological and environmental parameters, such as wind speed, air pressure, humidity, and temperature indicators inside the cave and atmospheric temperature and precipitation outside the cave, was conducted from 2019 to 2021, as well as encrypted monitoring in August and December 2019. The results showed that: (1) The meteorological parameters of Mahuang Cave exhibited seasonal characteristics and cyclical interannual variation. Cave wind speed, relative humidity, and temperature were high in summer and autumn and lowest in winter, whereas cave air pressure was high in winter and low in summer. The atmospheric temperature outside the cave was the main controlling factor. (2) On a short time scale, the dewpoint and temperature of Mahuang Cave did not change significantly, and an abrupt change phenomenon occurred mostly around noon. The warm season was more sensitive than the cold season, and the closer to the entrance of the cave, the stronger the response. (3) In terms of spatial distribution, the overall microclimate factors of Mahuang Cave became increasingly stable and entered a constant state with the increasing depth of the cave passage. The related effects of cave morphology and structure, the physical environment of the cave passage, air movement, and groundwater dynamics were important factors leading to an abrupt change phenomenon in cave microclimates. Local meteorological conditions and cave geometry controlled the temporal variability and spatial heterogeneity of the cave microclimate environment. [ABSTRACT FROM AUTHOR]

Unlike most brownfields located in the urban center, there is a kind of special brownfields produced in the Third Front Construction (TFC) period of China, and in turn they are named the Third Front Brownfield (TFB) in this paper. In addition to commercial value, other values should also be considered when TFBs are redeveloped, which makes they may need a specific protective reuse way and their revitalization process is relatively slower. Therefore, it is of great significance to study the redevelopment mode of TFBs. Accordingly, this paper presents a redevelopment mode selection framework to support stakeholders' investment decision-making and facilitate the reuse of TFBs. First, a previous case base including two sets is developed to conduct experience mining. In specific, an attribute set and a TFB redevelopment mode set of previous successful cases are established through literatures and expert interviews. Second, the weights of abovementioned attributes are determined by using the G1 method. Third, a concept of matching rate is defined based on the Attribute Similarity Model (ASM) to search the similarity between the new TFB and previous cases so that stakeholders can get advice on the redevelopment of the new TFB. A case study is conducted to show the effectiveness of the proposed framework and some policy suggestions are made according to the study process. [ABSTRACT FROM AUTHOR]

In October 2021, a wild bird-origin H3N8 influenza virus-A/Chinese pond heron/Jiangxi 5-1/2021 (H3N8)-was isolated from Chinese pond heron in China. Phylogenetic and molecular analyses were performed to characterize the genetic origin of the H3N8 strain. Phylogenetic analysis revealed that eight gene segments of this avian influenza virus H3N8 belong to Eurasian lineages. HA gene clustered with avian influenza viruses is circulating in poultry in southern China. The NA gene possibly originated from wild ducks in South Korea and has the highest homology (99.3%) with A/Wild duck/South Korea/KNU2020-104/2020 (H3N8), while other internal genes have a complex and wide range of origins. The HA cleavage site is PEKQTR↓GLF with one basic amino acid, Q226 and T228 at HA preferentially bind to the alpha-2,3-linked sialic acid receptor, non-deletion of the stalk region in the NA gene and no mutations at E627K and D701N of the PB2 protein, indicating that isolate A/Chinese pond heron/Jiangxi 5-1/2021 (H3N8) was a typical avian influenza with low pathogenicity. However, there are some mutations that may increase pathogenicity and transmission in mammals, such as N30D, T215A of M1 protein, and P42S of NS1 protein. In animal studies, A/Chinese pond heron/Jiangxi 5-1/2021 (H3N8) replicates inefficiently in the mouse lung and does not adapt well to the mammalian host. Overall, A/Chinese pond heron/Jiangxi 5-1/2021 (H3N8) is a novel wild bird-origin H3N8 influenza virus reassortant from influenza viruses of poultry and wild birds. This wild bird-origin avian influenza virus is associated with wild birds along the East Asian-Australasian flyway. Therefore, surveillance of avian influenza viruses in wild birds should be strengthened to assess their mutation and pandemic risk in advance. [ABSTRACT FROM AUTHOR]

The construction of large-scale hydropower stations could solve the problem of China's power and energy shortages. However, the construction of hydropower stations requires reservoir water storage. Artificially raising the water level by several tens of meters or even hundreds of meters will undoubtedly change the hydrogeological conditions of an area, which will lead to surface deformation near the reservoir. In this paper, we first used SBAS-InSAR technology to monitor the surface deformation near the Xiluodu reservoir area for various data and analyzed the surface deformation of the Xiluodu reservoir area from 2014 to 2019. By using the 12 ALOS2 ascending data, the 100 Sentinel-1 ascending data, and the 97 Sentinel-1 descending data, the horizontal and vertical deformations of the Xiluodu reservoir area were obtained. We found that the Xiluodu reservoir area is mainly deformed along the vertical shore, with a maximum deformation rate of 250 mm/a, accompanied by vertical deformation, and the maximum deformation rate is 60 mm/a. Furthermore, by analyzing the relationship between the horizontal deformation sequence, the vertical deformation sequence, and the impoundment, we found the following: (1) Since the commencement of Xiluodu water storage, the vertical shore direction displacement has continued to increase, indicating that the deformation caused by the water storage is not due to the elastic displacement caused by the load, but by irreversible shaping displacement. According to its development trend, we speculate that the vertical shore direction displacement will continue to increase until it eventually stabilizes; (2) Vertical displacement increases rapidly in the initial stage of water storage; after two water-storage cycles, absolute settlement begins to slow down in the vertical direction, but its deformation still changes with the change in the storage period. [ABSTRACT FROM AUTHOR]

The financing issue is increasingly becoming a key problem for brownfield remediation in public land ownership, and Public Private Partnership (PPP) mode is considered a potentially effective solution. However, some barriers impede the utilization of the PPP mode into brownfield remediation projects in the situation of public land ownership. By taking China as an example, the study investigates the barriers when the PPP mode is used in brownfield remediation projects to deal with financing dilemmas. Specifically, 39 original barriers are first obtained from existing related literature. Based on these original barriers, a semi-structured questionnaire is designed and used in a Delphi process to achieve 14 final barriers, which can reflect the particular situation in China. To identify the interrelationship among these barriers, Interpretative Structural Modeling (ISM) is used to map the hierarchical structure of the final barriers, and the Cross-Impact Matrix Multiplication Applied to Classification (MICMAC) analysis is applied to show the relationship strengths of barriers. According to the results of the ISM and MICMAC analyses, three key barriers are determined, and several corresponding recommendations are provided from the perspective of the public administration. [ABSTRACT FROM AUTHOR]

Fire prevention policies during different periods may lead to changes in the drivers of forest fires. Here, we use historical fire data and apply the boosted regression tree (BRT) model to analyze the spatial patterns and drivers of forest fires in the boreal forests of China from 1981 to 2020 (40 years). We divided the fire data into four periods using the old and new Chinese Forest Fire Regulations as a dividing line. Our objectives here were: to explore the influence of key historical events on the drivers of forest fires in northern China, establish a probability model of forest fire occurrence, and draw a probability map of forest fire occurrence and a fire risk zone map, so as to interpret the differences in the drivers of forest fires and fire risk changes over different periods. The results show that: (1) The model results from 1981 to 2020 (all years) did not improve between 2009 and 2020 (the most recent period), indicating the importance of choosing the appropriate modeling time series length and incorporating key historical events in future forest fire modeling; (2) Climate factors are a dominant factor affecting the occurrence of forest fires during different periods. In contrast with previous research, we found that here, it is particularly important to pay attention to the relevant indicators of the autumn fire prevention period (average surface temperature, sunshine hours) in the year before the fire occurrence. In addition, the altitude and the location of watchtowers were considered to have a significant effect on the occurrence of forest fires in the study area. (3) The medium and high fire risk areas in our three chosen time periods (1981–14 March 1988; 15 March 1988–2008; 2009–2020) have changed significantly. Fire risks were higher in the east and southeast areas of the study area in all periods. The northern primeval forest area had fewer medium-risk areas before the new and old regulations were formulated, but the medium-risk areas increased significantly after the old regulations were revised. Our study will help understand the drivers and fire risk distribution of forest fires in the boreal forests of China under the influence of history and will help decision-makers optimize fire management strategies to reduce potential fire risks. [ABSTRACT FROM AUTHOR]

Aedes albopictus is an indigenous primary vector of dengue and Zika viruses in China. Understanding the population spatial genetic structure, migration, and gene flow of vector species is critical to effectively preventing and controlling vector-borne diseases. The genetic variation and population structure of Ae. albopictus populations collected from 22 cities along the Yangtze River Basin were investigated with nine microsatellite loci and the mitochondrial CoxI gene. The polymorphic information content (PIC) values ranged from 0.534 to 0.871. The observed number of alleles (Na) values ranged from 5.455 to 11.455, and the effective number of alleles (Ne) values ranged from 3.106 to 4.041. The Shannon Index (I) ranged from 1.209 to 1.639. The observed heterozygosity (Ho) values ranged from 0.487 to 0.545. The FIS value ranged from 0.047 to 0.212. All Ae. albopictus populations were adequately allocated to three clades with significant genetic differences. Haplotype 2 is the most primitive molecular type and forms 26 other haplotypes after one or more site mutations. The rapid expansion of high-speed rail, aircraft routes and highways along the Yangtze River Basin have accelerated the dispersal and communication of mosquitoes, which appears to have contributed to inhibited population differentiation and promoted genetic diversity among Ae. albopictus populations. [ABSTRACT FROM AUTHOR]

Magnetotactic bacteria (MTB) biomineralize intracellular magnetic nanocrystals and swim along geomagnetic field lines. While few axenic MTB cultures exist, living cells can be separated magnetically from natural environments for analysis. The bacterial universal 27F/1492R primer pair has been used widely to amplify nearly full‐length 16S rRNA genes and to provide phylogenetic portraits of MTB communities. However, incomplete coverage and amplification biases inevitably prevent detection of some phylogenetically specific or non‐abundant MTB. Here, we propose a new formulation of the upstream 390F primer that we combined with the downstream 1492R primer to specifically amplify 1100‐bp 16S rRNA gene sequences of sulfate‐reducing MTB in freshwater sediments from Lake Weiyanghu, Xi'an, northwestern China. With correlative fluorescence in situ hybridization and scanning/transmission electron microscopy, three novel MTB strains (WYHR‐2, WYHR‐3 and WYHR‐4) from the Desulfobacterota phylum were identified phylogenetically and structurally at the single‐cell level. Strain WYHR‐2 produces bullet‐shaped magnetosome magnetite, while the other two strains produce both cubic/prismatic greigite and bullet‐shaped magnetite. Our results expand knowledge of bacterial diversity and magnetosome biomineralization of sulfate‐reducing MTB. We also propose a general strategy for identifying and characterizing uncultured MTB from natural environments. [ABSTRACT FROM AUTHOR]

Organophosphate esters (OPEs), substitutes of polybrominated diphenyl ethers, have been found in a variety of marine environmental matrices, whereas little is known about the feature and sources of seawater OPEs from the environments simultaneously affected by multiple anthropogenic activities. Jiaozhou Bay is one typical bay heavily disturbed by human activities, which was semi-enclosed and surrounded by large amounts of discharged rivers and catchments, various types of ports, and aquaculture farms. This study found that concentrations of Σ13OPEs ranged from 23.90 to 366.40 ng/L (median: 37.76 ng/L) in the seawater and from 90.15 to 1183.14 ng/L (median: 940.61 ng/L) in the inflowing river water. Tris (2-chloroisopropyl) phosphate, triethyl phosphate, and tris (2-chloroethyl) phosphate were the predominant congener, with the percentage of 43.76%, 22.80%, and 14.01%, respectively, in the bay water and 52.47%, 11.31%, and 23.66% in the river water. The overall spatial distribution was characterized by a higher concentration of Σ13OPEs and halogenated-OPEs in the nearshore sites and in the inflowing rivers, which were surrounded by urbanized areas with dense anthropogenic activities, especially along the eastern coast. Effluent discharge and vehicular and marine traffic emissions were distinguished as two main plausible sources of OPEs to Jiaozhou Bay, based on the principal component analysis and Spearman correlations. Ecological risk analysis indicated that Σ13OPEs posed a low risk to aquatic organisms in the bay and low-to-medium risks in the inflowing rivers. [ABSTRACT FROM AUTHOR]

This study combines data-driven-based logistic functions with prediction–area (P–A) plot for delineating target areas of orogenic Au deposits in the eastern margin of the Qinling metallogenic belt, central China. First, appropriate geological and geochemical factors were identified, optimized, and transformed into a series of fuzzy numbers with a range of 0–1 through a data-driven-based logistic function in order to determine the evidence layer for prospecting orogenic Au. In addition, the P–A plot was derived on the above evidence layers and their corresponding fuzzy overlay layers to pick out a proper prediction scheme, in the process of which acidic magmatic activity proved to be the most important factor of ore-controlling. Moreover, to further prove the advantages of this method, a traditional linear knowledge-driven approach was carried out for comparative purposes. Finally, based on concentration–area (C–A) fractal theory, the fractal thresholds were determined and a mineral prospecting map was generated. The obtained prediction map consisted of high, medium, low, and weak metallogenic potential areas, accounting for 2.5%, 16.1%, 38.4%, and 43% of the study area, containing 2, 3, 1, and 0 of the 6 known mine occurrences contained, respectively. The P–A plot indicated that the result predicted 83% of Au deposits with 17% of the area, confirming the joint application of the data-driven-based logistic function and P–A plot to be a simple, effective, and low-cost method for mineral prospectivity mapping, that can be a guidance for further work in the study area. [ABSTRACT FROM AUTHOR]

Background: A lack of adequate dietary knowledge may result in poor health. The purpose of this study was to study the association between dietary knowledge and overweight/obesity in children and adolescents.  METHOD: Data from the China Health and Nutrition Survey (CHNS) 2004, 2006, 2009, 2011, and 2015 were used in this cross-sectional study. The dietary knowledge of children and adolescents was evaluated by the questionnaire in the database. The overweight and obesity status was evaluated by body mass index (BMI). Cluster analysis was performed to establish different groups based on dietary knowledge level. Logistic regression analysis and subgroup analysis were conducted.Results: A total of 2,701 children and adolescents were finally selected. Cluster A (n = 837, 30.99%), Cluster B (n = 1,264, 46.80%) and Cluster C (n = 600, 22.21%) were high, medium and low dietary knowledge level, respectively. Participants with high dietary knowledge levels [OR = 0.56 (95%CI: 1.40-0.78)] may be negatively associated with overweight and obesity. Similar results were found among adolescents, males, females, people living in eastern and northeastern China, and rural areas, after adjusting for age, gender, geographic region, maternal education level, alcohol consumption, waist-to-hip ratio, systolic blood pressure and diastolic blood pressure.Conclusion: Improving the dietary knowledge level of children and adolescents was associated with decreased risk of overweight and obesity. Our study provided a theoretical basis for the relationship between dietary knowledge and overweight/obesity in Chinese children and adolescents and suggested strengthening the publicity and popularization of dietary knowledge in schools and communities. [ABSTRACT FROM AUTHOR]

Carbonate reservoirs commonly have significant heterogeneity and complex pore systems due to the multi-scale characteristic. Therefore, it is quite challenging to predict the petrophysical properties of such reservoirs based on restricted experimental data. In order to study the heterogeneity and size of the representative elementary volume (REV) of vuggy dolostones, a total of 26 samples with pore sizes ranging from micrometers to centimeters were collected from the Cambrian Xiaoerbulake Formation at the Kalping uplift in the Tarim Basin of northwestern China. In terms of the distribution of pore size and contribution of pores to porosity obtained by medical computed tomography testing, four types of pore systems (Types I–IV) were identified. The heterogeneity of carbonate reservoirs was further quantitatively evaluated by calculating the parameters of pore structure, heterogeneity, and porosity cyclicity. The results indicate that different pore systems yield variable porosities, pore structures, and heterogeneity. The porosity is relatively higher in Type-II and Type-IV samples compared to those of Type-I and Type-III. It is caused by well-developed large vugs in the former two types of samples, which increase porosity and reduce heterogeneity. Furthermore, the REV was calculated by deriving the coefficient of variation. Nine of the twenty-six samples reach the REV within the volume of traditional core plugs, which indicates that the REV sizes of vuggy dolostones are commonly much larger than the volume of traditional core plugs. Finally, this study indicates that REV sizes are affected by diverse factors. It can be effectively predicted by a new model established based on the relationship between REV sizes and quantitative parameters. The correlated coefficient of this model reaches 0.9320. The results of this study give more insights into accurately evaluating the petrophysical properties of vuggy carbonate reservoirs. [ABSTRACT FROM AUTHOR]

Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan (5-HTP) → serotonin (5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan; meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation, and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood–brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide, as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. Up-regulating gut microbiota tryptophan hydroxylase levels and down-regulating 5-hydroxytryptophan decarboxylase activity is the molecular mechanism of action of the anti-depressant drug Morinda officinalis oligosaccharides. [Display omitted] [ABSTRACT FROM AUTHOR]

The large amounts of emissions released by forest fires have a significant impact on the atmospheric environment, ecosystems, and human health. Revealing the main components of emissions released by forest fuel under different combustion states is of great importance to evaluate the impact of forest fires on the ecological environment. Here, a self-designed biomass combustion system was used to simulate the combustion of different parts (i.e., branch, trunk, and bark) of five tree species and branches, and three layers of surface dead fuel (i.e., litter layer, semi-humus layer, and humus layer) of three shrub species, in the Daxing'an Mountains, Inner Mongolia. The emission characteristics of the main gas pollutants (i.e., CO, CO2, HC, and NOx) and PM2.5 released under the two combustion states of smoldering and flaming, along with the correlation ratio among emission factors, were measured. The results show that the average amounts of emissions released by different trees and the three layers of surface dead fuel from a smoldering state are higher than those from the flaming state, while shrub combustion shows the opposite. The emissions released by trees, shrubs, and surface dead fuel from the flaming state are ordered from high to low as follows: CO2 > CO > HC > NOx > PM2.5; and from the smoldering state as CO2 > CO > HC > PM2.5 > NOx, indicating that the primary emissions under both conditions are mainly due to CO2, CO, and HC, while the emissions of NOx and PM2.5 are dependent on the combustion state—flaming promotes the emission of NOx, while smoldering promotes the emission of PM2.5. The average emissions of PM2.5 from the branches, bark, and trunks of Quercus mongolica are significantly higher than those of the other four tree species in the smoldering state, and the emissions of PM2.5 from the five tree species are ordered as follows: bark > branch > trunk. This study will help to further understand the impact of forest fires on the atmospheric environment and ecosystems in Northern China. [ABSTRACT FROM AUTHOR]

• Confirming the random distribution of JE cases both on the scale of villages. • Detecting different spatial cluster pattern in two sites on the level of district. • Diversity correlated features for JE cases on the level of district and village. Japanese encephalitis (JE) is a mosquito-borne disease with a spatial distribution that is linked to geo-environmental factors. The spatial distribution of JE cases and correlated geo-environmental factors were investigated in two critical counties in southern and northern China. Based on maps, enhanced thematic mapper (ETM) remote sensing datasets from Landsat and spatial datasets of JE cases, spatial distribution and spatial cluster analyses of JE cases at the village scale were performed by using the standard deviational ellipse and Ripleys K-function. Global and regional spatial cluster analyses of JE cases were also performed by using Moran's index. Regression analysis was used to analyze the relationships between geo-environmental characteristics and the risk of JE cases. At the study sites, the JE cases were not spatially clustered at the village or district (global) level, whereas there was a spatial cluster at the district (local) level. Diversity-related features for JE patients at the district and village levels were detected at two sites. In the southern counties, the distance of a village from a road was related to the village-level JE risk (OR: 0.530, 95 CI: 0.297–0.947, P = 0.032), and the number of township-level JE cases was linked to the distance of the district center from the road (R =-0.467, P = 0.025) and road length (R = 0.516, P = 0.012) in the administrative area. In northern China, the modified normalized difference water index (MNDWI) in the 5 km buffer around the village was related to village-level JE risk (OR: 0.702, 95% CI: 0.524–0.940, P = 0.018), and the number of township-level JE cases was related to the MNDWI in the administrative region (R =-0.522, P = 0.038). This study elucidates the spatial distribution patterns of JE cases and risk, as well as correlated geo-environmental features, at various spatial scales. This study will significantly assist the JE control efforts of the local Centers for Disease Control and Prevention (CDC), which is the base-level CDC, particularly concerning the allocation of medicine and medical staff, the development of immunological plans, and the allocation of pesticides and other control measures for the mosquito vectors of JE. [ABSTRACT FROM AUTHOR]

Purpose: To retrospectively collect and analyze demographic information as well as symptoms, laboratory results, endoscopic and pathologic findings, and treatment of ulcerative colitis (UC) and Crohn's disease (CD) patients in Wuhan, China. Methods: Patients who were diagnosed as inflammatory bowel disease (IBD) and hospitalized from January 2012 to December 2017 were enrolled in this study. The clinical characteristics including symptoms, laboratory results, and treatment were reviewed and analyzed. Results: Totally 821 cases were screened, and finally 430 UC patients and 286 CD patients were selected and enrolled in this study. The most common symptom in UC patients was bloody stool (90.7%) followed by diarrhea (87.7%), mucus in stool (72.1%), and abdominal pain (66.3%), which were significantly different from those of CD patients (P < 0.01). In contrast, the most common symptom in CD patients was abdominal pain (80.0%) followed by diarrhea (58.4%), bloody stool (27.6%), and fever (18.2%). Erythrocyte sedimentation, C-reactive protein, and platelets were significantly increased, while hemoglobin was decreased, in the moderately or highly active IBD. The percentage of positive perinuclear anti-neutrophil cytoplasmic antibody was significantly higher in UC patients (31.1%) than that in CD patients (4.8%, P < 0.001), while the percentage of positive anti-intestinal goblet cell antibody was significantly higher in CD patients (23.1%) than that in UC patients (14.9%, P = 0.037). Conclusion: The findings of the current study may provide evidence-based information for Chinese gastroenterologists to treat IBD more effectively in the future. [ABSTRACT FROM AUTHOR]

For a typical pipeline-lifting deep-sea mining system, marine mining pipelines have higher requirements for steel welding. After the pipeline steel is welded, a large amount of residual stress will be generated inside the component because the heat treatment is not carried out, causing the pipeline to form stress corrosion cracks in the seawater environment. For high residual stress, the blind hole method has inaccurate measurement accuracy. Based on the theory of solid mechanics, this paper comprehensively considers the distance between the strain grid and the center of the hole. It introduces the ratio γ of the applied stress to the yield strength of the specimen. The strain relief coefficients under the values were investigated. The variation trend of the strain release coefficient distribution with the γ value of the three kinds of strain gauge flowers commonly used in China was discussed. Finally, the variation law of strain release coefficient with γ value was obtained by fitting. The strain release coefficient was corrected to improve the accuracy of the blind hole method for measuring high residual stress, which provides a reference value for the engineering application of the blind hole method. This has important theoretical significance and engineering value for guiding the welding construction of high-strength pipeline steel in a deep-sea environment. [ABSTRACT FROM AUTHOR]

Background: To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital. Methods: From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. We analyzed age-related gender preferences, tumor locations, and the histological grades of the tumors. In addition, the epidemiological characteristics of the five most common intracranial tumors were compared to the previous studies. Results: In this study, intracranial and spinal tumors account for 96.4% (3066) and 3.6% (114) of all tumors, with a preponderance of supratentorial tumors (57.9%). Among all pediatric patients, low-grade tumors comprise 67.1% (2 135). The integral gender ratio of males to females is 1.47: 1 and the average age of patients is 7.59 years old. The five most common intracranial tumors are craniopharyngioma (15.4%), medulloblastoma (14.3%), pilocytic astrocytoma (11.8%), diffuse astrocytoma (9.8%), and anaplastic ependymoma (4.8%). Conclusions: Due to the lack of national data on childhood brain tumors, we used a large nationally representative population sample based on the largest pediatric neurosurgery center in China. We analyzed the data of the past 5 years, reflecting the incidence of CNS tumors in Chinese children to a certain extent, and laying a data foundation for subsequent clinical studies. [ABSTRACT FROM AUTHOR]

Dengue fever virus (DENV) is a mosquito-borne flavivirus that poses a serious risk to human health. Aedes albopictus is a widely distributed vector of dengue fever in China. Based on the impact of physiological activity, the microbiome in A. albopictus will provide a novel environment-friendly approach to control DENV transmission. We performed metagenomic sequencing on A. albopictus before and after exposure to DENV blood meal to detect microbiome variation of A. albopictus with different susceptibilities to DENV. The dominant phyla in A. albopictus microbiome were Proteobacteria and Ascomycota , and the dominant genera were Aspergillus and Metarhizium. Gammaproteobacteria bacterium , Lactobacillus harbinensis , and Neurospora crassa differed significantly after DENV infection. There were 15 different microorganisms found to be involved in mosquito immunity and metabolism, such as Alphaproteobacteria bacterium , Methyloglobulus morosus , and Shigella sonnei , which might have an impact on the DENV susceptibility of A. albopictus. It was hypothesized that the lack of specific bacteria may lead to increased susceptibility of A. albopictus to DENV. Interventions in the microbiome composition or specific bacteria of A. albopictus may affect the susceptibility to DENV and control the mosquito-borne diseases efficiently. [ABSTRACT FROM AUTHOR]

The failure depth of the working face floor caused by mining is a key parameter to predict water inrush from the working face floor. Extensive research has been conducted on the floor failure zone of the working face. However, in recent years, there have been few studies on the floor failure law of the working face with a super-large mining height (over 20 m) in the western mining area of China. In this paper, the working face with a super-large mining height of 24 m in Longwanggou Coal Mine was studied. Electrical monitoring and numerical simulation of the working face floor were carried out. The measured floor failure depth of the working face is 15 m while the average numerical simulation result is 11 m. When compared with the calculation results of the statistical analysis formulas, the floor failure depth of the working face with a super large mining height obtained from field measurement and numerical simulation is smaller. The reason for the smaller failure zone of the floor of the super large mining height working face is that the falling roof inhibits the pressure relief of the floor, the large mining height reduces the advance pressure, and the shear stress of the floor decreases. The research methods and findings are of great significance to the prediction of floor failure and water inrush in working face with a super-large mining height, the prevention and control of water disasters in coal seam roof and the monitoring of mine pressure. [ABSTRACT FROM AUTHOR]

The intelligent regulation and control strategies for rice and wheat combine harvesters' operation are lacking and the rule of parameter matching is fuzzy in China, around these issues. The dynamic correlation control law among the parameters of rice and wheat, cleaning operation parameters of combine harvesters, the cleaning loss rate and impurity rate, and so on are studied. The intelligent control model for the rice and wheat combine harvester is established based on case-based reasoning (CBR). According to different rice and wheat varieties, water content and other rice and wheat properties, the control scheme of cleaning fan speed, air distributor plate angle and upper sieve opening with low cleaning impurity rate and cleaning loss rate is provided. Through the development of web-based cleaning intelligent control expert system and experimental evaluation, the feasibility and effectiveness of the CBR method in the intelligent control filed of rice and wheat combine harvesters are verified. [ABSTRACT FROM AUTHOR]

Most of the existing sluices in China have been in operation for more than 40 years, and the aging problem is becoming increasingly prominent. The selection of reinforcement schemes for sluices in vulnerable conditions is of great significance to the whole project. A reasonable reinforcement scheme can ensure their safe operation and reduce unnecessary resource investment. This study focuses on the diversion gate of a bridge in China that through aging has emerged insufficient capacity of downstream energy dissipation and scour prevention, severe scour of the diversion dike foundation, and insufficient flood control and rescue capacity. Two reinforcement schemes are examined by analyzing the engineering parameters of the bridge diversion sluice and the necessity of engineering construction, namely, raising the flood discharge level and increasing the width of the overflow section. In this study, Super Decisions software was first used to simulate the reinforcement scheme of the bridge diversion sluice, calculate the weight of the factors, and obtain the optimization scheme from the two aforementioned reinforcement schemes, which was based on the analytic network process (ANP), and the related factors affecting the reinforcement scheme of the bridge diversion sluice are determined and evaluated. The relevant calculation and analyses of the optimization scheme are conducted using ANSYS finite-element software. The selection process of reinforcement scheme for such sluices provides a reference for other similar projects. [ABSTRACT FROM AUTHOR]

This paper constructs an evaluation index system for the development level of inclusive finance from four dimensions: the availability of financial services, the degree of utilization of financial services, the depth of financial services, and the sustainability of financial services. We use the standard deviation modified G1 combination weighting method to determine index weight and measure the development level of inclusive finance in China's 31 provincial administrative regions. The research results show that the overall level of development of inclusive finance in China is quite different, and the development of various regions is unbalanced. We should focus on increasing the depth of use of financial services and promote the sustainability of inclusive finance. [ABSTRACT FROM AUTHOR]

Background: Though many randomized control trials had examined the effectiveness and safety of taking insulin therapy with or without metformin, there are limited real-world data, especially among Chinese type 2 diabetes patients initiating basal insulin (BI) with uncontrolled hyperglycemia by oral agents. This study was designed to assess the effectiveness and safety of BI therapy combined with or without metformin in a real-world national cohort study. Methods: Patients with type 2 diabetes mellitus who initiated BI treatment due to uncontrolled hyperglycemia (HbA1c≥7 %) by oral antidiabetic drugs (OADs) were recruited in Chinese real-world settings between 2011 and 2013. A total of 12,358 patients initiated BI without bolus insulin and completed a 6-month follow-up were selected as the study population and divided into BI with metformin or BI without metformin group based on whether metformin was simultaneously prescribed or not at baseline. Propensity score adjustment was used to balance baseline covariates between two groups. A sub-analysis was also conducted among 8,086 patients who kept baseline treatment regimen during the follow-up. Outcomes were HbA1c, hypoglycemia, weight gain and insulin dose in two groups. Results: 53.6 % (6,621 out of 12,358) patients initiated BI therapy concomitant with metformin. After propensity score adjustment, multivariate regression analysis controlled with number of OADs, total insulin dose, physical activity and diet consumption showed that BI with metformin group had a slightly higher control rate of HbA1c <7.0 % (39.9 % vs. 36.4 %, P = 0.0011) at 6-month follow-up, and lower dose increment from baseline to 6-month (0.0064 vs. 0.0068 U/day/kg, P = 0.0035). The sub-analysis with patients remained at same BI therapy further showed that BI with metformin group had higher HbA1c control rate (47.9 % vs. 41.9 %, P = 0.0001), less weight gain (-0.12 vs. 0.15 kg P = 0.0013), and lower dose increment during 6-month follow-up (0.0033 vs. 0.0037 U/day/kg, P = 0.0073) when compared with BI without metformin group. Conclusions: In alliance with current guidelines, the real-world findings also support the insulin initiation together with metformin. Continuous patients' education and clinicians training are needed to improve the use of metformin when initiating BI treatment. [ABSTRACT FROM AUTHOR]

The Huangmaohai estuary (HE) is a funnel-shaped microtidal estuary in the west of the Pearl River Delta (PRD) in southern China. Since China reformed and opened up in 1978, extensive human activities have occurred and greatly changed the estuary's topography and modified its hydrodynamics. In this study, we examined the morphological evolution by analyzing remote sensing data with ArcGIS tools and studied the responses of hydrodynamics to the changes in topography from 1977 to 2010 by using the Delft3D model. We took the changes in estuarine circulation during neap tides in dry seasons as an example. The results show that human reclamation caused a narrowing of the estuary, and channel dredging deepened the estuary. These human activities changed both the longitudinal and lateral estuarine circulations. The longitudinal circulation was observed to increase with the deepening and narrowing of the estuary. The lateral circulation experienced changes in both the magnitude and pattern. The momentum balance analysis shows that when the depth and width changed simultaneously, the longitudinal estuarine circulation was modulated by both the channel deepening and width reduction, in which the friction, pressure gradient force, and advection terms were altered. The analysis of the longitudinal vortex dynamics indicates that the changes in the vertical shear of the longitudinal flow, lateral salinity gradient, and vertical mixing were responsible for the change in the lateral circulation. The changes in water depth are the dominant factors affecting lateral circulation intensity. This study has implications for sediment transport and morphological evolution in estuaries heavily impacted by human interventions. [ABSTRACT FROM AUTHOR]

The understanding of the initial ground stress field in a deep and long tunnel can help to optimize the support structure design and reduce the occurrence of collapse and other failures in tunnel construction and operation periods. Daxiangling Tunnel is a deep and long tunnel under multiple faults condition, many collapses, rock bursts, and large deformations occurring during construction. This paper presents a study of initial ground stress field regression analysis in Daxiangling Tunnel. A three-dimensional geomechanical model with faults is established first, which satisfies the deformation compatibility equation at the fault location. Then, according to the superposition principle, the distribution of regional stress field under the fault condition is obtained by the method of partition inversion. The results show that the distribution of the ground stress field in the Daxiangling Tunnel areas is mainly tectonic stress. The horizontal stress in the area is greater than the vertical stress, and the extreme value appears at the maximum excavation depth. Owing to fault extrusion shear, the stress relaxation exists in the stratum near the fault. The regression analysis results are generally consistent with the measured results, and the relative error is controlled within 10%. However, owing to the boundary effect of the finite element model, the regression stress values near the tunnel entrance and exit are distorted. This can be corrected by applying a mathematical statistical method to obtain the initial stress field of the Daxiangling tunnels with higher applicability. [ABSTRACT FROM AUTHOR]

In this study, 84 scenes Sentinel-1A satellite datasets from October 2016 to September 2019 were used to analyze surface deformation in East Dongting Lake, China, by employing the small baseline subset interferometric synthetic aperture radar (SBAS-InSAR) method. The data are divided into two seasons, i.e., the flood and dry seasons. It was suggested that the surface deformation is related to the distribution of the river network and water flow activities. During the dry season, the water flow is active along the internal river, scouring the surrounding soil. During the flood season, the water flow basically occurs around the external drainage network. By qualitatively comparing surface deformation and precipitation changes as well as changes in soil erosion, it is found that the deformation was highly related to soil erosion and seasonal precipitation. The precipitation in the flood period is heavy than that in the dry season. Therefore, the runoff with amount silt will scour the soil in the passing area, resulting obvious surface deformation. During the dry period, surface deformation is smaller due to the less precipitation. [ABSTRACT FROM AUTHOR]

The main purpose of this study was to investigate the effect of work-related factors, fatigue, risky behaviours on accident involvement among different age groups of taxi drivers in China. A total of 2391 taxi drivers were selected to complete a self-reported questionnaire about their demographic data and information on working conditions, fatigue, risky behaviours, as well as involvement in traffic accidents between 2014 and 2016. The drivers were divided into three categories according to their age. Then, a set of comparative analyses and three structural equation models were used to analyze the samples of specific age groups. The results indicated that taxi drivers in the younger group rest the least with the most dissatisfaction with income while those in the mid-age group worked the longest time and were charged the most management fee, but the older taxi drivers more frequently engaged in risky behaviours and traffic accidents. Furthermore, two mediating chain processes were confirmed (i.e. 'work-related factors – fatigue – accidents' and 'work-related factors – risky behaviours – accidents') across the three age groups. However, the causes of fatigue, risky behaviours and accidents in different age groups are not exactly the same. These findings suggest that the regulation of the taxi industry should be carefully improved. Incentive policy and education aimed at taxi drivers may also hold promise. [ABSTRACT FROM AUTHOR]

Today, strategy of repair remains controversial and rare analyses on annular integrity associated with outcomes in complete repair by RVOT incision were performed in a large TOF cohort in China. This is a retrospective cohort study involving patients with TOF who had undergone complete repair by RVOT incision between January 2012 and December 2017 in Fuwai hospital. The primary outcome was a composite of reintervention, significant pulmonary regurgitation (PR) and significant annular peak gradient (APG). Multivariate Cox proportional-hazards model analyses were used to assess the relationships between annular integrity and outcomes. In total, 1673 survival patients with the median age of 318 days were included, and 1002 were male. During a median follow-up of 49 months, 538 participants developed the primary outcome (27 reinterventions). Multivariate Cox analyses showed that compared with AS, TAP was associated with an increased risk of primary outcome (adjusted HR, 1.94 [95% CI 1.60–2.37]) and the results remained unchanged even in most subgroups defined. In secondary outcomes analyses, TAP is associated with a higher risk of reintervention (adjusted HR, 3.32 [95% CI 1.25–8.79]) and significant PR (adjusted HR, 2.51 [95% CI 2.00–3.16]). However, TAP is not associated with a decreased risk of significant APG (adjusted HR, 1.33 [95% CI 0.94–1.88]). PVA integrity preservation is important in complete repair of TOF with RVOT incision. TAP is associated with a higher risk of reintervention and significant PR, and with a similar risk of significant APG. Significant APG in AS patients at discharge has a downtrend over time. [ABSTRACT FROM AUTHOR]

Background: Aedes albopictus is an indigenous primary vector for dengue and Zika viruses in China. Compared with its insecticide resistance, biology and vector competence, little is known about its genetic variation, which corresponds to environmental variations. Thus, the present study examines how Ae. albopictus varies among different climatic regions in China and deciphers its potential dispersal patterns. Methods: The genetic variation and population structure of 17 Ae. albopictus populations collected from three climatic regions of China were investigated with 11 microsatellite loci and the mitochondrial coxI gene. Results: Of 44 isolated microsatellite markers, 11 pairs were chosen for genotyping analysis and had an average PIC value of 0.713, representing high polymorphism. The number of alleles was high in each population, with the ne value increasing from the temperate region (3.876) to the tropical region (4.144). Twenty-five coxI haplotypes were detected, and the highest diversity was observed in the tropical region. The mean Ho value (ca. 0.557) of all the regions was significantly lower than the mean He value (ca. 0.684), with nearly all populations significantly departing from HWE and displaying significant population expansion (p value < 0.05). Two genetically isolated groups and three haplotype clades were evaluated via STRUCTURE and haplotype phylogenetic analyses, and the tropical populations were significantly isolated from those in the other regions. Most genetic variation in Ae. albopictus was detected within populations and individuals at 31.40 and 63.04%, respectively, via the AMOVA test, and a relatively significant positive correlation was observed among only the temperate populations via IBD analysis (R2 = 0.6614, p = 0.048). Recent dispersions were observed among different Ae. albopictus populations, and four major migration trends with high gene flow (Nm > 0.4) were reconstructed between the tropical region and the other two regions. Environmental factors, especially temperature and rainfall, may be the leading causes of genetic diversity in different climatic regions. Conclusions: Continuous dispersion contributes to the genetic communication of Ae. albopictus populations across different climatic regions, and environmental factors, especially temperature and rainfall, may be the leading causes of genetic variation. [ABSTRACT FROM AUTHOR]

Caledonian orogeny is another important tectonic event in South China Block after the breakup of the Rodinia supercontinent. With a view to constrain the tectonic evolution and proto–basin in South China, this paper reports the geochemical and zircon U‐Pb dating data of the Ordovician strata in central Hunan, South China. Geochemical features and paleocurrent directions suggest that the lower Ordovician deposited in a passive continental margin basin with a provenance of quartzose components and showing an affinity with the Yangtze Block. U‐Pb age data for 260 detrital zircons from upper Ordovician identify three major age populations as: 900–1200 Ma, 1400–1800 Ma and 2400–2700 Ma. The detrital zircon age spectrum as well as the paleocurrent directions suggest that upper Ordovician deposited in a foreland basin and showing a close affinity with the Cathaysia Block. It is also suggest that the lower Ordovician continuously accepted the mineral from the Yangtze Block, whereas the provenance of the upper Ordovician sedimentary basin changed from the Yangtze Block to the Cathaysia Block. This change implies a tectonic movement, which caused the transformation of the proto–basin in the Hunan area in SCB from passive continental margin basin to foreland basin probably took place during late Ordovician. This fact also demonstrate that the Caledonian orogeny in South China Block began no later than 453 Ma, and a new crustal evolution model is proposed. [ABSTRACT FROM AUTHOR]