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The coronavirus virus (COVID-19) epidemic has swept the world, with the World Health Organization defining it as a pandemic on March 11. This in turn has affected the approaches and methods used in education throughout the world. According to United Nations report, by the time of mid-April 2020, 94% of learners in more than 200 countries around the world have been affected, and 1.58 billion students from pre-school to higher education are affected. In response to increased learning needs regarding infection prevention, the Ministry of Education has also provided cloud educational resources and private online learning resources, platforms, and tools to schools at all levels to encourage teachers and students to make effective use of digital resources. Although the government provides abundant teaching resources, the implementation of distance teaching in college physical education still faced with many problems, such as the shortage of course resources, the lack of information literacy of teachers, the difficulty in implementing conventional teaching plans online, the limited conditions for students to exercise at home, and the doubts about online physical education. Therefore, this study proposes a new teaching method, and studies, analyzes and discusses this method. The method of experimental design was adopted in this study to divide the students into two groups: blended learning group (synchronous and asynchronous) and single type learning group (synchronous). The results show that blended learning students perform better than single type learning students in all these aspects, which proves the practicability and effectiveness of the proposed method.

The carcinogenicity of benzene was reevaluated by the International Agency for Research on Cancer in 2017, with the Working Group reaffirming positive yet inconclusive associations with non‐Hodgkin lymphoma (NHL). To extend our previous observation of a significant exposure‐response for cumulative occupational benzene exposure and NHL risk among Chinese women in a population‐based cohort in Shanghai, we extended follow‐up of this cohort and pooled the data with a similarly designed population‐based cohort of men in Shanghai. Cumulative exposure estimates were derived for 134,449 participants in the pooled analysis by combining ordinal job‐exposure matrix intensity ratings with quantitative benzene measurements from an inspection database of Shanghai factories. Associations between benzene exposure metrics and NHL (n = 363 cases including multiple myeloma [MM]) were assessed using Cox proportional hazard models. Ever occupational exposure to benzene in the pooled population was associated with NHL risk (HR = 1.5, 95% CI = 1.2–2.0), and exposure‐response relationships were observed for increasing duration (ptrend =.003) and cumulative exposure (ptrend =.003). Associations with ever exposure, duration, and cumulative exposure were similar for NHL with and without MM in the case definition, including lifetime cumulative exposures in the highest quartile (HR = 1.6, 95% CI = 1.1–2.4 with MM included; HR = 1.7, 95% CI = 1.1–2.7 with MM excluded). An elevated risk of the chronic lymphocytic leukemia subtype was suggested in the pooled analyses (HR for ever vs. never exposure = 2.3, 95% CI = 0.9–5.6). These observations provide additional support for a plausible association between occupational benzene exposure and risk of NHL. [ABSTRACT FROM AUTHOR]

This study is the first to examine the gender gap in academic patenting among faculty members in Chinese universities, a critical issue for the sustainable development of scientific research and innovation. Using a unique dataset that includes the patenting activities and professional status of 1,836 faculty members in life science-related departments at 36 top Chinese universities, this research reveals an evolving landscape of patenting dynamics. The trend of male faculty members leading in the annual number of patent applications and patents granted has shifted among newly graduated faculty members. Female faculty submit and receive their first patent applications significantly earlier than male faculty. However, male faculty are more likely to be lead inventors, and this gender gap remains difficult to close, with female faculty more likely to be supporting inventors. This research is contextualized within the broader framework of China's university tenure reform and the growing presence of women in the life sciences. While progress is evident, the study uncovers persistent systemic barriers that prevent women from fully translating their research into patentable innovations. By identifying these social and institutional barriers, our study not only sheds light on the gender gap, but also suggests policy measures to promote gender equity in scientific innovation, making it a critical read for policymakers and academic leaders. [ABSTRACT FROM AUTHOR]

Streptococcus pneumoniae infection is a major public health concern with high morbidity and mortality rates. This study aimed to evaluate the serotype distribution, antimicrobial resistance changes, clonal composition, and virulence factors of S. pneumoniae isolates causing pneumococcal disease in northeast China from 2000 to 2021. A total of 1,454 S. pneumoniae isolates were included, with 568 invasive strains and 886 non-invasive strains. The patients from whom the S. pneumoniae were isolated ranged in age from 26 days to 95 years, with those ≤ 5 years old comprising the largest group (67.19%). 19 F, 19 A, 23 F, 14, and 6B were the most common serotypes, of which 19 A and 19 F were the main serotypes of invasive and non-invasive S. pneumoniae, respectively. CC271 was the most common multilocus sequence type. Serotype 14 had the lowest expression of cbpA, rrgA, and psrP genes, but expression levels of 19 A and 19 F genes were similar. All isolates were sensitive to ertapenem, moxifloxacin, linezolid, and vancomycin but highly resistant to macrolides, tetracyclines, and cotrimoxazole. Simultaneous resistance to erythromycin, clindamycin, tetracyclines, and trimethoprim/sulfamethoxazole was common pattern among multidrug-resistant isolates. Non-invasive S. pneumoniae had higher resistance to β-lactam antibiotics than invasive strains. 19 A and 19 F were the main strains of penicillin-resistant S. pneumoniae. The resistance rate of β-lactam antibiotics decreased from 2017 to 2021 compared to previous periods. Including PCV13 in the national immunization program can reduce the morbidity and mortality rates of pneumococcal disease effectively. [ABSTRACT FROM AUTHOR]

Background Psoas abscess (PA) is an uncommon disease that has been increasingly reported in the recent years. We reviewed patients with PA and analyzed their clinical characteristics to improve our understanding of this rare disorder. Methods We retrospectively reviewed the clinical presentations, microbiology, and outcomes of patients with PA between 2011 and 2022 at the Zhejiang Provincial People's Hospital in China. Results There were 40 adult patients identified with the discharge diagnosis of PA. The mean age was 60 years, and 67.5% of the patients were male. Primary symptoms were typically nonspecific. In all, 20 abscesses were considered secondary, and the most common was infective spondylitis. The most common causative organism for primary PA was Staphylococcus aureus , followed by Escherichia coli , whereas multiple bacterial species were found in secondary abscesses. The overall in-hospital mortality rate was 5%. Patients with secondary PA had a longer hospital stay. Conclusion PA, as a serious infectious condition, usually presents with nonspecific symptoms and laboratory test results, making early diagnosis difficult. These profiles differed from those reported in the present study. The initial clinical status and subsequent imaging studies can lead to favorable outcomes. What is already known on this topic Psoas abscess (PA) is an uncommon disease with nonspecific symptoms and laboratory test results that few studies were seen. What this study adds Patients with psoas abscess showed clinical characteristics different from previous reports. The causative organism was found to be multiple. How this study might affect research, practice, or policy We suggest that a thorough medical history and subsequent imaging studies can be useful for the diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Background: Protothecosis is an infection of humans and animals caused by a rare conditionally pathogenic fungus (prototheca). It can occur in immunocompromised or normal patients. Aims: To describe the epidemiology of prototheca infection in China. Methods: We report a case of successful treatment of cutaneous protothecosis with fluconazole and analyzed the epidemiological characteristics, risk factors, clinical manifestations, diagnosis, treatment and prognosis of prototheca infections in China. Results: We describe this case and 29 cases of prototheca infections in China. At present, Prototheca wickerhamii (Pw) infection is the most common infection in China, and single or combined itraconazole is the preferred treatment. Conclusions: These results provide detailed information and relevant clinical treatment strategies for the diagnosis and treatment of protothecosis in China. [ABSTRACT FROM AUTHOR]

The visit of Bertrand Russell to China during 1920 to 1921 was one of the most significant events in May Fourth Movement, and Russell pointed out that education was the most important thing for Chinese reconstruction. The author argues that we should interpret Russell's educational idea of China from a theoretic and practical point of view. The man in Chinese education is the key to the future of China.

The demand for the power grid system's capacity to undergo peak-shaving is increasing as the proportion of renewable energy rises. In China, nuclear power units usually only provide a base load operation in the view of safety and economic considerations, but they do not provide load adjustment services, which undoubtedly increases the pressure of grid load adjustment. In this paper, a novel flexibility load adjustment strategy of the CHP nuclear unit is studied, which is achieved by introducing the thermal storage tank (TST) into the Rankine cycle without changing the output of the nuclear reactor. The AP1000 pressurized water reactor nuclear power unit for combined heat and power is taken as an example, and the thermodynamic model is established through the water vapor equation. Furthermore, the reference system is simulated for the goal of minimizing the imbalance between power supply and demand, and the flexibility–environment–economy benefits are evaluated. The results show that the heat storage/release of the TST may achieve power output flexible adjustment of the nuclear unit, and the power imbalance of the reference energy system is reduced from 1107.99 MWh to 457.24 MWh, a reduction of 58.73%. The introduction of a 600 MWh TST can enable the reference unit to contribute 335 MWh of peak electricity within the reference day. From the perspective of replacing the power generation output increment of coal-fired power units with equal amounts, it can achieve a reduction of 106.09 tons of coal consumption in the case day, which means that 277.73 tons of CO2 emissions can be reduced. The profit of the reference unit can be improved by CHY 70,125 via participating in load adjustment in the case day if following the time-of-use electricity price. [ABSTRACT FROM AUTHOR]

Dissolved oxygen (DO) plays a pivotal role in sustaining marine ecosystems. The Bohai Sea in China is a semi-enclosed sea, and oxygen-deficit events occur from time to time due to human activities. At present, there is a notable absence of any convenient and precise method for obtaining three-dimensional spatial data on DO, and the exploration of the physical mechanisms influencing oxygen deficit remains incomplete. This investigation uses the linear radial basis function (RBF-Linear) fitting method to conduct three-dimensional spatial interpolation for DO, which demonstrates minimal inaccuracy. Then, the RBF-Linear fitting method is utilized to collect a comprehensive three-dimensional spatial dataset encompassing temperature, salinity, and DO in the Bohai Sea in August from 2016 to 2018. The results indicate discernible interannual variations in the extent, area, and distribution of oxygen deficiency during summer in the Bohai Sea. Mechanism analysis reveals that intense precipitation episodes and an increase in wind stress curl exacerbate oxygen depletion. Additionally, the degree, location, and area of the two oxygen-deficit cores (off the Yellow River Estuary and off the Qinhuangdao) in the Bohai Sea are influenced by several factors, including current velocity, direction, local circulation position, and net horizontal transport rate. Furthermore, the study suggests that oxygen deficiency in the Bohai Sea region is currently in its early stages, with a limited degree of injury and a restricted range of influence. The use of a three-dimensional spatial interpolation method to create a complete DO field in three-dimensional space simplifies the research challenges associated with marine oxygen deficit. Moreover, this study holds particular significance for guiding the development of marine fisheries. [ABSTRACT FROM AUTHOR]

Objectives: The timing of tracheostomy for critically ill patients on mechanical ventilation (MV) is a topic of controversy. Our objective was to determine the most suitable timing for tracheostomy in patients undergoing MV. Design: Retrospective cohort study. Setting and participants: One thousand eight hundred eighty-four hospitalisations received tracheostomy from January 2011 to December 2020 in a Chinese tertiary hospital. Methods: Tracheostomy timing was divided into three groups: early tracheostomy (ET), intermediate tracheostomy (IMT), and late tracheostomy (LT), based on the duration from tracheal intubation to tracheostomy. We established two criteria to classify the timing of tracheostomy for data analysis: Criteria I (ET ≤ 5 days, 5 days < IMT ≤ 10 days, LT > 10 days) and Criteria II (ET ≤ 7 days, 7 days < IMT ≤ 14 days, LT > 14 days). Parameters such as length of ICU stay, length of hospital stay, and duration of MV were used to evaluate outcomes. Additionally, the outcomes were categorized as good prognosis, poor prognosis, and death based on the manner of hospital discharge. Student's t-test, analysis of variance (ANOVA), Mann–Whitney U test, Kruskal–Wallis test, Chi-square test, and Fisher's exact test were employed as appropriate to assess differences in demographic data and individual characteristics among the ET, IMT, and LT groups. Univariate Cox regression model and multivariable Cox proportional hazards regression model were utilized to determine whether delaying tracheostomy would increase the risk of death. Results: In both of two criterion, patients with delayed tracheostomies had longer hospital stays (p < 0.001), ICU stays (p < 0.001), total time receiving MV (p < 0.001), time receiving MV before tracheostomy (p < 0.001), time receiving MV after tracheostomy (p < 0.001), and sedation durations. Similar results were also found in sub-population diagnosed as trauma, neurogenic or digestive disorders. Multinomial Logistic regression identified LT was independently associated with poor prognosis, whereas ET conferred no clinical benefits compared with IMT. Conclusions: In a mixed ICU population, delayed tracheostomy prolonged ICU and hospital stays, sedation durations, and time receiving MV. Multinomial logistic regression analysis identified delayed tracheostomies as independently correlated with worse outcomes. Trial registration: ChiCTR2100043905. Registered 05 March 2021.http://www.chictr.org.cn/listbycreater.aspx [ABSTRACT FROM AUTHOR]

On a global scale, soil respiration (Rs), representing the CO2 flux between the soil surface and the atmosphere, ranks as the second-largest terrestrial carbon (C) flux. Understanding the dynamics between Rs and its autotrophic (Ra) and heterotrophic (Rh) components is necessary for accurately evaluating and predicting global C balance and net ecosystem production under environmental change. In this study, we conducted a two-year root exclusion experiment in subtropical China's Camphor (Cinnamomum camphora (L.) Presl.) forests to assess seasonal changes in Ra and Rh and their relative contributions to Rs. Additionally, we examined the influence of environmental factors on the dynamics of Ra, Rh, and Rs. Our results showed that seasonal mean Rs values were 2.88 µmol m−2 s−1, with mean Ra and Rh of 1.21 and 1.67 µmol m−2 s−1, respectively, in the studied forests. On an annual basis, the annual values of mean Rs in the studied forests were 405 ± 219 g C m−2 year−1, with Rh and Ra accounting for 240 ± 120 and 164 ± 102 g C m−2 year−1, respectively. The seasonal mean ratio of Rh to Rs (Rh/Rs) was 58%, varying from 45 to 81%. Seasonal changes in Rs and Rh were strongly correlated with soil temperature but not soil water content. Both Rh and Rs increased exponentially with the average soil temperature measured in the topsoil layer (about 5 cm), with Q10 values of 2.02 and 1.73 for Rh and Rs, respectively. Our results suggest that the composition and activity of soil microbes and fauna play a primary role in releasing carbon flux from soil to the atmosphere in the studied forest ecosystems. [ABSTRACT FROM AUTHOR]

This study introduces a novel large three-dimensional physical model experimental system (PMES) for studying the geomechanical problems related to deep underground engineering. The apparatus is mainly composed of a counterforce frame, a hydraulic loading subsystem, a sample installation and transportation subsystem, an excavation subsystem, an integrated monitoring subsystem, and auxiliary facilities. During the design and development of the PMES apparatus, key technological issues were addressed. A high-stiffness frame structure with opening and closing function was developed. Uniform, gradient, and designed non-uniform stresses can be applied with high accuracy. An independent long-term load-holding unit and a surface dynamic disturbance unit were designed. The basic and innovative functions of the apparatus were verified through calibration experiments. A large physical model experiment was conducted to simulate the excavation of a deep-buried drainage tunnel in China's Jinping-II hydropower station. The experiment obtained the failure processes of the surrounding rock masses induced by high in-situ stress, specific engineering geological structures and excavation disturbance. The internal fracturing and strain evolution within the sample were successfully captured by the integrated monitoring subsystem. The results also validated the reliability of this novel apparatus. The development of this novel apparatus provides a new tool for the study of geomechanical problems in deep underground engineering. Highlights: A novel large three-dimensional physical model experimental system for studying the geomechanical problems related to deep underground engineering was established. The basic and innovative functions of the apparatus were verified through calibration experiments. A large physical model experiment was conducted to simulate the excavation of a deep tunnel in China's Jinping-II hydropower station. [ABSTRACT FROM AUTHOR]

This study aims to investigate the proportion and distribution of female HPB surgeons in China, describe their current status, and analyze the possible barriers and challenges in their careers. Tertiary hospitals with the division of HPB in mainland China in 2021 were enrolled and surgeon demographic information was collected through the review of official websites and/or telephone interviews. The majority of female HPB surgeons (72.92%) were located in the first or second-tier cities in mainland China, with an increasing number of new female HPB surgeons entering the field annually, particularly after 2005 (from 27 to 52 per 5 years). Despite no significant difference in academic backgrounds, female HPB surgeons initiated their careers at an earlier age and took a longer time to obtain chief titles (P < 0.05). Interestingly, female HPB surgeons performed laparoscopic complex HPB cases at a similar rate (95.42%) to their male counterparts and were more likely to specialize in endoscopic surgery (P = 0.021), with a similar ratio of obtaining administrative positions. Minimally invasive surgery may provide females with unprecedented opportunities in the HPB surgery field. However, despite the increasing numbers of female HPB surgeons, the proportion remains low in China. [ABSTRACT FROM AUTHOR]

We conducted a short-term laboratory soil warming incubation experiment, sampling both warmed and un-warmed soils from a subtropical plantation in southeastern China, incubating them at 20 °C, 30 °C, and 40 °C. Our aim was to study the SOC mineralization response to increasing temperatures. Our findings revealed that the temperature sensitivity (Q10) of SOC mineralization to short-term experimental warming varied between the warmed soil and the un-warmed soil. The Q10 of the un-warmed soil escalated with the temperature treatment (20–30 °C: 1.31, 30–40 °C: 1.63). Conversely, the Q10 of the warmed soil decreased (20–30 °C: 1.57, 30–40 °C: 1.41). Increasing temperature treatments decreased soil substrate availability (dissolved organic C) in both un-warmed and warmed soil. The C-degrading enzyme in un-warmed soil and warmed soil had different trends at different temperatures. In addition, warming decreased soil microbial biomass, resulting in a decrease in the total amount of phospholipid fatty acids (PLFAs) and a decrease in the abundance of fungi and Gram-negative bacteria (GN) in both un-warmed and warmed soil. The ratio of fungal to bacterial biomass (F:B) in un-warming soil was significantly higher than that in warmed soil. A drop in the microbial quotient (qMBC) coupled with a rise in the metabolic quotient (qCO2) indicated that warming amplified microbial respiration over microbial growth. The differential Q10 of SOC mineralization in un-warmed and warmed soil, in response to temperature across varying soil, can primarily be attributed to shifts in soil dissolved organic C (DOC), alterations in C-degrading enzyme activities, and modifications in microbial communities (F:B). [ABSTRACT FROM AUTHOR]

Objectives: The incidence of multiple primary lung cancer (MPLC) has increased in recent years. The risk factors of MPLC are not well studied, especially in the Asian population. This case-control study investigated the association between a family history of cancer and MPLC risk. Methods: We used data from people who surgically confirmed MPLC with at least 2 nodes of Fujian Medical University Union Hospital and matched 1:2 normal individuals as controls between 2016 and 2017. Information on age, sex, lifestyle, personal history, and family history of cancer was collected using a self-administered questionnaire, and odds ratios (OR) were estimated using unconditional logistic regression. Results: We included 2 104 patients. In total, 321 patients with histologically confirmed MPLC and 642 healthy controls were studied. The significantly higher ratio of current smokers was observed for the cases than the controls (54.1% vs. 30.0%). A family history of LC in first-degree relatives of the cases reported a significantly higher proportion than in the controls (15.3% vs. 8.6%). Family history of all cancers and LC significantly increased the risk of MPLC (OR = 1.64, P = 0.009 and OR = 2.59, P = 0.000, respectively). The multivariate analysis identified a significantly increased risk of MPLC (OR = 2.45, P = 0.000) associated with parents and siblings influenced by LC history. The younger age (aged < 55 years) of LC cases at diagnosis exhibited a significantly increased risk of MPLC (OR = 2.39, P = 0.000). A significant association with a family history of LC was found for male squamous carcinoma and male adenocarcinoma (OR = 1.59, p = 0.037 and OR = 1.64, p = 0.032, respectively). A positive association with LC history was only observed for female adenocarcinoma (OR = 2.23, p = 0.028). The risk of MPLC was not significantly associated with A family history of cancers in non-smokers (OR = 0.91, P = 0.236). Ever-smokers with a positive family history of cancer or LC had a significantly elevated risk of MPLC (OR = 4.01, P = 0.000 and OR = 6.49, P = 0.000, respectively). We also observed a very elevated risk for smokers with no family history (OR = 3.49, P = 0.000). Such a positive association was also observed in ever-smokers with no family history of LC (OR = 3.55, P = 0.000). Adenocarcinoma in females was prevalent and significantly associated with a family history of LC in risk of MPLC compared with other histologic subtypes. Conclusions: Our findings suggest an association between a family history of LC and MPLC risk among an Asian population. Smoking status and family history of LC have a synergistic effect on MPLC. These findings indicate that MPLC exhibits familiar aggregation and that inherited genetic susceptibility may contribute to the development of MPLC. [ABSTRACT FROM AUTHOR]

Recent psycholinguistic research has made significant progress in understanding the meaning-access process during pun comprehension. However, to date, little research has directly investigated how the two retrieved meanings are integrated into the pun context afterwards. In the current ERP study, we examined this process by comparing homophone puns with two control conditions. Different from previous ERP studies on jokes, we did not observe significantly enhanced N400 amplitudes (300-500 ms) in the pun condition, indicating no apparent detection of incongruity. However, we observed a sustained positivity around the left anterior regions (500-900 ms) and enhanced LPC amplitudes around the central-parietal regions (600-900 ms). These two components could index the sudden access to the second meaning and the additional integration operations to establish a new cognitive model respectively. These findings were compatible with the Space Structure Model, which emphasises the frame-shifting process as a crucial element for understanding verbal humour. [ABSTRACT FROM AUTHOR]

Background: Previous studies have reported that after laparoscopic cystectomy of ovarial endometrioma, the ovarian response to gonadotropin (Gn) significantly decreased. However, for patients with diminished ovarian reserve (DOR) after ovarian surgery, how to choose the most appropriate controlled ovarian hyperstimulation protocol has not been concluded. Compared with the traditional agonist regimen, the gonadotropin (Gn)-releasing hormone (GnRH) antagonist, microstimulation, and progestin-primed ovarian stimulation (PPOS) protocols are simple to operate and have a shorter cycle, which are often used in patients with DOR. So the purpose of our study is to compare the assisted reproductive outcomes of these three controlled ovarian hyperstimulation protocols in patients with DOR following laparoscopic cystectomy of ovarial endometrioma. Methods: In this retrospective cohort study, 89 patients with DOR who had undergone in vitro fertilisation/intracytoplasmic sperm injection at the Department of Reproductive Medicine at the Third Affiliated Hospital of Zhengzhou University from 1 to 2018 to 31 December 2020 were included. According to the controlled ovarian hyperstimulation protocols employed, the patients were divided into GnRH antagonist (38 patients), PPOS (27 patients), and microstimulation (24 patients) groups. The basic data and clinical outcomes of the three groups were compared. The main outcome measure was the cumulative live birth rate. Results: No significant differences in the age of the female patients and their spouses and female patients' body mass index and basal endocrine levels (follicle-stimulating hormone and oestradiol) were noted among the three groups (P > 0.05). The GnRH antagonist group had higher antral follicle counts, greater endometrial thickness on the human chorionic Gn injection day, greater number of oocytes retrieved, and higher two pronuclear embryo counts than did the other two groups. However, the starting dosage of Gn was lower in the GnRH antagonist group than in the other two groups. The microstimulation group had a significantly higher oocyte output rate and high-quality embryo rate than did the other two groups (P < 0.05). No significant differences in the total dosage of Gn, cumulative pregnancy rate, cumulative live birth rate, viable embryo rate, and blastocyst formation rate were observed among the three groups (P > 0.05). Conclusion: In conclusion, for patients aged under 40 years who experienced DOR after laparoscopic cystectomy of ovarial endometrioma, GnRH antagonist protocol and PPOS protocol can obtain better ovulation induction outcomes and cumulative live birth rate than microstimulation protocol, and are more suitable ovulation induction protocols. [ABSTRACT FROM AUTHOR]

Background: Sheep genomes undergo numerous genes losses, gains and mutation that generates genome variability among breeds of the same species after long time natural and artificial selection. However, the microevolution of native sheep in northwest China remains elusive. Our aim was to compare the genomes and relevant reproductive traits of four sheep breeds from different climatic environments, to unveil the selection challenges that this species cope with, and the microevolutionary differences in sheep genomes. Here, we resequenced the genomes of 4 representative sheep breeds in northwest China, including Kazakh sheep and Duolang sheep of native breeds, and Hu sheep and Suffolk sheep of exotic breeds with different reproductive characteristics. Results: We found that these four breeds had a similar expansion experience from ~ 10,000 to 1,000,000 years ago. In the past 10,000 years, the selection intensity of the four breeds was inconsistent, resulting in differences in reproductive traits. We explored the sheep variome and selection signatures by FST and θπ. The genomic regions containing genes associated with different reproductive traits that may be potential targets for breeding and selection were detected. Furthermore, non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds with different reproductive characteristics were found. We identified PAK1, CYP19A1 and PER1 as a likely causal gene for seasonal reproduction in native sheep through qPCR, Western blot and ELISA analyses. Also, the haplotype frequencies of 3 tested gene regions related to reproduction were significantly different among four sheep breeds. Conclusions: Our results provide insights into the microevolution of native sheep and valuable genomic information for identifying genes associated with important reproductive traits in sheep. [ABSTRACT FROM AUTHOR]

STUDY QUESTION What is the effect of defects in the manchette protein IQ motif-containing N (IQCN) on sperm flagellar assembly? SUMMARY ANSWER Deficiency in IQCN causes sperm flagellar assembly defects and male infertility. WHAT IS KNOWN ALREADY The manchette is a transient structure that is involved in the shaping of the human spermatid nucleus and protein transport within flagella. Our group recently reported that the manchette protein IQCN is essential for fertilization. Variants in IQCN lead to total fertilization failure and defective acrosome structure phenotypes. However, the function of IQCN in sperm flagellar assembly is still unknown. STUDY DESIGN, SIZE, DURATION Fifty men with infertility were recruited from a university-affiliated center from January 2014 to October 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS Genomic DNA was extracted from the peripheral blood samples of all 50 individuals for whole-exome sequencing. The ultrastructure of the spermatozoa was assessed by transmission electron microscopy. Computer-assisted sperm analysis (CASA) was used to test the parameters of curvilinear velocity (VCL), straight-line velocity (VSL), and average path velocity (VAP). An Iqcn knockout (Iqcn−/−) mouse model was generated by CRISPR–Cas9 technology to evaluate sperm motility and the ultrastructure of the flagellum. Hyperactivation and sperm fertilizing ability were assessed in a mouse model. Immunoprecipitation followed by liquid chromatography–mass spectrometry was used to detect IQCN-binding proteins. Immunofluorescence was used to validate the localization of IQCN-binding proteins. MAIN RESULTS AND THE ROLE OF CHANCE Biallelic variants in IQCN (c.3913A>T and c.3040A>G; c.2453_2454del) were identified in our cohort of infertile men. The sperm from the affected individuals showed an irregular '9 + 2' structure of the flagellum, which resulted in abnormal CASA parameters. Similar phenotypes were observed in Iqcn−/− male mice. VSL, VCL, and VAP in the sperm of Iqcn−/− male mice were significantly lower than those in Iqcn+/+ male mice. Partial peripheral doublet microtubules (DMTs) and outer dense fibers (ODFs) were absent, or a chaotic arrangement of DMTs was observed in the principal piece and end piece of the sperm flagellum. Hyperactivation and IVF ability were impaired in Iqcn−/− male mice. In addition, we investigated the causes of motility defects and identified IQCN-binding proteins including CDC42 and the intraflagellar transport protein families that regulate flagellar assembly during spermiogenesis. LIMITATIONS, REASONS FOR CAUTION More cases are needed to demonstrate the relation between IQCN variants and phenotypes. WIDER IMPLICATIONS OF THE FINDINGS Our findings expand the genetic and phenotypic spectrum of IQCN variants in causing male infertility, providing a genetic marker for sperm motility deficiency and male infertility. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the National Natural Science Foundation of China (81974230 and 82202053), the Changsha Municipal Natural Science Foundation (kq2202072), the Hunan Provincial Natural Science Foundation (2022JJ40658), and the Scientific Research Foundation of Reproductive and Genetic Hospital of CITIC-Xiangya (YNXM-202114 and YNXM-202201). No conflicts of interest were declared. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]

Gestational weight management in obese women is critical in clinical work. Adverse pregnancy outcomes are associated with improper gestational weight gain (GWG). However, the pattern of GWG (PGWG) and its correlation with hypertensive disorders of pregnancy (HDP) in obesity are still unclear in China. This retrospective cohort study evaluates clinical data from 799 women through multivariate analyses and trajectory analyses. All the participants are stratified per first trimester weight gain category into three groups (Inadequate‐1st, <0.5 kg; Adequate‐1st, 0.5–2.0 kg; Excessive‐1st, >2.0 kg) and PGWG refers to the weekly weight gain during each gestational period. GWG is positively associated with first trimester weight gain. 78.4% of the Excessive‐1st participants have excessive total GWG, in contrast to Inadequate‐1st (32.7%) and Adequate‐1st (48.2%). After 20 weeks, the weekly weight gain rapidly accelerates, and 77.3% have a weekly weight gain exceeding the Institute of Medicine recommendations. Trajectory analysis of weekly weight gain based on HDP shows two separate weight gain curves after 20 weeks in women with and without a high risk of HDP. Especially in Excessive‐1st participants, weekly weight gain after 20 weeks over 0.32 kg/w is positively related to the risk of HDP (<0.32 kg/w vs. 0.32–0.61 kg/w, adjusted odds ratios [aOR]: 2.999, 95% confidence interval [CI]: 1.054–8.537; <0.32 kg/w vs. >0.61 kg/w, aOR: 5.362, 95% CI: 1.719–16.729). In summary, the first trimester is critical for gestational weight management in obesity. Excessive weight gain during the first trimester and after 20 weeks predicts a high risk of HDP, which should be noted in clinical practice. Highlights: The pattern of gestational weight gain in women with obesity is intricate.The first trimester is the critical period for gestational weight management.Improper gestational weight gain reminds a potentially high risk of hypertensive disorders of pregnancy. [ABSTRACT FROM AUTHOR]

Proto‐Tethyan orogenic processes prior to the late Ordovician collision remain unclear. Both whole‐rock La/Yb‐ and zircon Eu/Eu*‐based crustal thickness proxies along with petrological and geological observations were used to reconstruct mountain‐building history for the West Kunlun orogenic belt, China, over the span of Early Palaeozoic. Here, we demonstrate that Proto‐Tethyan West Kunlun crust has observed significant accretionary orogeneses at 520–480 Ma and 480–450 Ma and collisional orogenesis at 450–400 Ma. The 520–480 Ma accretionary orogenesis in West Kunlun together with the coeval Delamerian accretionary contractional orogenesis in eastern Australia were simultaneously induced by continent‐continent collisions that welded the Gondwana landmass. Ca. 440 Ma docking of Tarim and its eastern neighbouring blocks along the northern margin of Gondwana in turn triggered the Lachlan accretionary orogenesis along the opposite margin. This study highlights that accretionary orogenesis could be a manifestation of far‐field compressional stress from continent‐continent collision. [ABSTRACT FROM AUTHOR]

The purpose of this study is to add new insights into the mechanism through which job satisfaction relates to job performance. Affective commitment was tested as a potential mediator between job satisfaction and job performance, and traditionality was used as a potential moderator between job satisfaction and affective commitment. A survey study was conducted on 292 employees from seven companies in China. The study findings suggest that affective commitment serves as one of the mechanisms through which job satisfaction influences job performance. Job satisfaction can strengthen people's identification with, involvement in, and emotional attachment to their organization which in turn can foster better performance. The second major finding of this study is that cultural values influence how well people translate job satisfaction into affective commitment. People who are culturally more traditional tend to transfer their satisfaction with their job into stronger commitment than people lower in cultural traditionality. HRD implications are drawn. (Contains 1 figure and 4 tables.)

Background: In China, many ornamental plants associated with Buddhist figures, including the Sakyamuni, Bodhisattva, and Arhat, were grown and worshiped because of their cultural and religious significance. However, the systematic collation and ethnobotanical information about these culturally important plants have yet to be fully understood. Methods: Online information was collected from 93 e-commercial platforms for ornamental plants all over China. Field sampling was conducted in 16 ornamental markets and 163 Buddhist temples using key informant interviews and participatory observation with traders, tourists, and local disciples. The types, distributions, and associated characteristics of the screened plants were summarized and the evolving characteristics of these ornamental plants were analyzed. Results: A total of 60 ornamental plants, including six varieties and one subspecies, were screened, of which 43 species were associated with Sakyamuni, 13 with Bodhisattva, and four with Arhat. Among the 60 species, three were regarded as the Asoka tree related to Buddha's birth, ten as the Bodhi tree connected to Buddha's enlightenment, three as the Sal tree associated with Buddha's nirvana, nine were related to Buddha's head, belly, or hand, and 18 were connected with Buddha as lotus throne, bamboo monastery, or Bodhi beads. The evolving characteristics of these ornamental plants primarily constituted the substitution of the original plants by similar native plant species, followed by the introduced species with comparable morphology to the Buddhist figures. Conclusions: People grow ornamental plants associated with Buddhist figures to reflect their love and praise for plants and Buddha. The association between the ornamental plants and Buddhist figures will aid the inheritance of Buddhist culture and promote ornamental plants in the commercial market. Thus, the ethnobotany of ornamental plants associated with Buddhist figures can serve as a basis for future investigation of modern Buddhist culture. [ABSTRACT FROM AUTHOR]

Wildfires exert strong influences on the environment, ecology, economy and public security. However, the existing hourly Himawari-8 fire product produced by the Japan Meteorological Agency (JMA) presents large uncertainties and is not suitable for reliable real-time fire monitoring in China. To fill this gap, the National Satellite Meteorological Center (NSMC) proposed an adaptive hourly Himawari-8 fire product for China based on the original Himawari-8 source by employing a dynamical threshold for fire extraction and a database of ground thermal sources. According to the visually extracted reference and consistency check, we found that the NSMC-Himawari-8 fire product effectively removed a majority of false fire alarms included in the original Himawari-8 fire product. Based on a rare field-collected ground reference dataset, we evaluated the reliability of original Himawari-8 and NSMC-Himawari-8 fire products across China. The overall accuracy of the raw Himawari-8 fire product was 54 % and 59 % (not considering the omission errors), respectively. As a comparison, by identifying more real fire pixels and avoiding a majority of false fire alarms, the overall accuracy of the NSMC-Himawari-8 fire product was 80 % and 84 % (not considering the omission errors), respectively, making it an ideal source for improved real-time fire monitoring across China. This research also provides a useful reference for employing a local dataset of underlying surfaces and thermal sources to enhance the accuracy of global fire products in specific regions. The NSMC-Himawari-8 fire product can be downloaded at http://figshare.com (last access: 17 April 2023) with the following DOI: 10.6084/m9.figshare.21550248 (Chen et al., 2022a). [ABSTRACT FROM AUTHOR]

Aim: Mycorrhiza play key roles for ecosystem structure and functioning in forests. However, how different mycorrhizal types influence mountain forest biodiversity–ecosystem functioning (BEF) relationships are largely unknown. We evaluate how the diversity of distinct mycorrhiza‐associated fungi and trees shapes forest carbon storage along elevational gradients. Location: Gaoligong Mountains within Hengduan Mountains, Southwest China. Taxon: Seed plants and mycorrhizal fungi. Methods: We used the data from 31 subtropical forest plots along elevational gradients on two aspects (east and west) of the mountain. We quantified species richness of trees and symbiotic fungi and assigned both to their mycorrhizal type (arbuscular mycorrhiza [AM], ectomycorrhiza [EcM] and ericoid mycorrhiza [ErM]). We then examined the diversity effects of mycorrhiza‐associated fungi and trees on above‐ground carbon stored in trees and organic carbon stored in soils. Results: Species richness was highest for AM trees (79.5%), followed by ErM trees (13.4%) and then EcM trees (7.1%). Species richness of AM‐associated trees and fungi decreased with increasing elevation, while ErM‐associated trees and fungi showed an opposite trend. EcM‐associated diversity followed a hump‐shaped relationship with elevation. Positive relationships between diversity and above‐ground carbon were detected in all three mycorrhizal associations, but despite low species number, canopy‐dominating EcM trees comprised 64.4% of the amount of above‐ground carbon. Furthermore, community‐weighted means of height exhibited positive correlations with forest above‐ground carbon, indicating that positive selection effects occur. Soil organic carbon was positively related to EcM‐associated fungi diversity, above‐ground carbon mass and soil nitrogen availability, with the latter having strongest direct effects. Main Conclusions: The distributions of forest biodiversity and carbon storage can be modulated by distinct mycorrhizal fungi and trees. Moreover, future global changes (e.g. climate warming, intensifying nitrogen deposition) could alter the mycorrhizal‐mediated BEF relationships in mountain forests. [ABSTRACT FROM AUTHOR]

Background: Cancer-related fatigue (CRF) is one of the most commonly reported symptoms impacting cancer survivors. This study evaluated and compared the effectiveness and safety of acupuncture treatments for CRF. Methods: We searched PubMed, Embase, Web of Science, Cochrane Library, China Biology Medicine China National Knowledge Infrastructure, China Science and Technology Journal Database, and WanFang Database from inception to November 2022 to identify eligible randomized controlled trials (RCTs) comparing acupuncture treatments with sham interventions, waitlist (WL), or usual care (UC) for CRF treatment. The outcomes included the Cancer Fatigue Scale (CFS) and Pittsburgh Sleep Quality Index (PSQI), and pair-wise and Bayesian network meta-analyses were performed using STATA v17.0. Results: In total, 34 randomized controlled trials featuring 2632 participants were included. In the network meta-analysis, the primary analysis using CFS illustrated that point application (PA) + UC (standardized mean difference [SMD] = -1.33, 95% CI = -2.02, -0.63) had the highest probability of improving CFS, followed by manual acupuncture (MA) + PA (SMD = -1.21, 95% CI = -2.05, -0.38) and MA + UC (SMD = -0.80, 95% CI = -1.50, -0.09). Moreover, the adverse events of these interventions were acceptable. Conclusion: This study demonstrated that acupuncture was effective and safe on CRF treatment. However, further studies are still warranted by incorporating more large-scale and high-quality RCTs. [ABSTRACT FROM AUTHOR]

Microbes depolymerize soil organic matter to supply themselves with carbon (C), and nutrients such as nitrogen (N) and phosphorus (P). In this way, microbial resource limitations play an important role in characterizing the biogeochemical cycle dynamics of the ecosystem. However, the effect of warming on microbial resource limitations, especially in resource-poor subsoils, remains unclear. Therefore, this study aimed to examine the effects of warming (+ 5 °C above ambient) on microbial resource limitation and explored their relationships with soil physicochemical properties and microbial community structure in topsoil (0–10 cm) and subsoil (40–60 cm) in a Chinese fir (Cunninghamia lanceolata) plantation in southern China. Microbial resource limitation with warming treatment was assessed via vector analysis of soil extracellular enzymatic stoichiometry after two years. We found warming aggravated microbial C limitation in the topsoil but alleviated microbial C limitation in the subsoil, while it shifted the relative nutrient limitation from P limitation to N limitation in the subsoil. Soil microbial C limitation was explained by soil properties (specifically, ammonium nitrogen) in the topsoil while by microbial community composition in the subsoil based on variance partition analysis. The soil microbial nutrient limitation was explained by soil properties in the topsoil and subsoil. The decrease in actinomycetes abundance in the warming treatment may have led to a decreased microbial C limitation in the subsoil. Our study highlighted the differences in warming effects between the topsoil and subsoil. We argue that the microbial resource demand of the subsoil should be further implemented in the study of soil biogeochemistry to improve the prediction of the impact of climate warming on soil C dynamics. [ABSTRACT FROM AUTHOR]

Evolution of terrestrial infauna in the Early Triassic enables to understand terrestrial biotic recovery after the end‐Permian mass extinction (EPME). Six ichnospecies in two ichnogenera, including Skolithos linearis, S. verticalis, S. annulatus, S. isp., Planolites montanus, and P. beverleyensis, were recognized from the Lower Triassic Liujiagou Formation (Induan Stage) and Heshanggou Formation (Olenekian Stage) in the Baiping section of the Dengfeng area, North China. The ichno‐ecological analyses of ichno‐taxonomic abundance, ichnodiversity, bioturbation index, burrow size, and tiering level revealed that terrestrial infauna expanded from epibenthic to endobenthic through the Early Triassic. The tiering deepening suggested that tracemakers gradually began to excavate into the sediments instead of moving on the microbial mats, indicating that the burrowing capability of trace‐making animals has recovered in the Olenekian. Four types of sedimentary substrates were summarized: non‐bioturbated matground, matground with bioturbated patches, weakly bioturbated mixed ground, and moderately bioturbated mixed ground. Occurrence of the substrate of mixed ground may be a sign of the initial recovery of the terrestrial ecosystem after the EPME. [ABSTRACT FROM AUTHOR]

As train speeds continuously increase, the crosswind stability of high-speed trains (HSTs) has been a prominent research topic. Benefiting from advances in railway technology, the coupled operation of different HSTs has been proven to be permissible, but the crosswind performance of double-connected train groups composed of different kinds of HSTs has rarely been studied. This paper therefore studied the differences in the aerodynamic performance of double-connected train groups composed of same and different train units under crosswinds. We employed an improved delayed detached-eddy simulation (IDDES) method to investigate the flow features around different groups of double-connected train. Two one-eighth-scale standard HSTs—Train 1 (T 1) and Train 2 (T 2)—currently operating in China were selected to form different group configurations for double-connected trains: T 1-T 1 (Case 1–1), T 1-T 2 (Case 1–2), T 2-T 1 (Case 2–1), and T 2-T 2 (Case 2–2). First, the reliability of the numerical algorithm and mesh independence were verified to ensure the accuracy of the numerical results. Second, the aerodynamic force coefficients, time-averaged, and instantaneous flow structures of different double-connected train group types were compared and analyzed. [ABSTRACT FROM AUTHOR]

Peanut (Arachis hypogaea L.) is one of the most important crops produced worldwide. Peanut is the dominant crop in the typical upland red soil areas of China; however, phosphorus bioavailability in red soil is very low, which severely affects peanut production. To improve the phosphorus bioavailability, which substantially promotes the green development of peanut production, a peanut–green manure rotation field experiment was conducted with six treatments (milkvetch; radish; brassica rape; mustard rape; winter fallow and no-tillage), commencing in September 2017 in the red soil area of Jiangxi province, China. The results show that compared with no-tillage (NT) treatments, different green manure returning treatments had significant effects on soil pH, soil phosphorus components and available potassium content. The particulate phosphorus and soil available phosphorus contents in the green manure treatments were significantly higher than those in the winter fallow (WF) treatment. Compared with the WF treatment, the content of particulate phosphorous in brassica rape (BR), radish (R) and milkvetch (MV) treatments was significantly increased by 6.55%, 3.66% and 2.50%, respectively; the available phosphorus content in mustard rape (MR), BR, R and MV was significantly increased by 20.93%, 25.60%, 23.76% and 18.10%, respectively. In addition, the total phosphorus content of peanut shell in the MV and R treatment was significantly higher than that in the WF treatment, increasing by 33.47% and 60.66%, respectively. Compared with the WF treatment, the peanut biomass of MR, BR and R treatments increased significantly by 19.51%, 29.83% and 19.77%, respectively. The total phosphorus accumulation in all green manure treatments was higher than that in the WF treatment, and the MV treatment reached a significant level at 18.83%. Based on these results, the particulate phosphorus (PP) and available phosphorus were significantly affected by different green manure treatments; green manure amendment improves peanut phosphorus uptake. The use of green manure (especially milkvetch and brassica rape) can be recommended to improve phosphorus bioavailability and yield of peanut in red soil areas. [ABSTRACT FROM AUTHOR]

Purpose: Evidence from several cohorts has suggested that a higher intake of isoflavone is associated with lower risk of lung cancer in never smokers, but the association has not been investigated by histologic type of lung cancer. Adenocarcinoma is a common histologic type found in never smokers. We hypothesized that a higher intake of isoflavone is associated with a lower risk of lung adenocarcinoma among never smokers. Here, we examined the associations of isoflavone and soy food intake with lung cancer and its histologic types in never smokers. Methods: We performed a pooled analysis using data from the Japan Public Health Center-based Prospective Study, Shanghai Women's Health Study and Shanghai Men's Study with 147,296 never smokers aged 40–74 years with no history of cancer. During 1,990,040 person-years of follow-up, 1247 lung cancer cases were documented. Dietary isoflavone and soy food intake were assessed using a food-frequency questionnaire. Multivariable Cox proportional hazards models assessed the associations between isoflavone and soy intake with incidence of lung cancer by histologic type. Results: A higher intake of dietary isoflavone and soy food were associated with reduced risk of lung adenocarcinoma. The multivariable hazard ratios (HRs) (95% CI) of risk of lung adenocarcinoma for the highest versus lowest intakes of isoflavone and soy food were 0.74 (0.60–0.92) and 0.78 (0.63–0.96), respectively. The multivariable HRs of risk of lung adenocarcinoma associated with each 10 mg/day increase in isoflavone and each 50 g/day increase in soy food intake were 0.81 (0.70–0.94) and 0.84 (0.73–0.96), respectively. Conclusion: Higher intake of isoflavone and soy food was associated with lower risk of lung adenocarcinoma in never smokers. [ABSTRACT FROM AUTHOR]

Inorganic fertilizers have been widely used to achieve high apple yields throughout China, especially in Northwest China. This approach has adverse effects on apple orchard soil environments and greenhouse gas (GHG) emissions. Therefore, we investigated the effects of combined organic and inorganic fertilizers on GHG emissions, soil properties, and apple yield to assess the greenhouse gas inventory and to determine which fertilization manner is good for the sustainable development of apple orchards. A split plot design was used, with main treatment of fertilizer ditch (FD) site and a bare soil (BS) site, each with four subtreatments: organic fertilizer–goat manure (M), chemical fertilizer (NPK), chemical fertilizer combined with organic fertilizer–goat manure (MNPK), and control (CK). The cumulative N2O emissions at the FD site were higher than those at the BS site (by 105.72%). The N2O emissions ranged from approximately 0.95–5.91 kg ha−1 and were higher in the MNPK treatment than in the other treatments. The cumulative CH4 uptake from each treatment was generally negative (1.06–7.67 kg ha−1). Compared to the other treatments, the MNPK treatment applied at the FD site led to an increased global warming potential. At both the FD and BS sites, the MNPK treatment led to a lower greenhouse gas intensity than the NPK treatment. Nitrates nitrogen (NO3−-N), water-filled pore space, and temperature all influenced GHG emissions. These results showed that the MNPK treatment was more conducive than the other treatments to the sustainable development of apple orchards in the Loess Plateau region of China. [ABSTRACT FROM AUTHOR]

Background: In clinical practice, combined segmental resection (CSS) can avoid resection of multiple segments to preserve lung function. When two or more distant lung segments or subsegments of the same lobe present with a ground glass opacity (GGO) that meets the indications for sublobar resection, conventional CSS or wedge resection could not remove all the nodules, and lobectomy is performed in most of these patients. For these particular types of nodules, we perform a single lobe noncombined subsegmental resection, or "separated" precise subsegmentectomy, to preserve more lung tissue. This study was designed to initially assess the feasibility and safety of "separated" precise subsegmentectomy. Methods: Selected cases of specific GGO were subjected to "separated" precise subsegmentectomy and the results of general clinical data, perioperative operative time, bleeding, length of stay, computed tomography (CT) review, lung function and its dynamic changes were collected and analyzed in these patients. Results: "Separated" precise subsegmentectomy was performed in 12 patients and successfully completed. The median operation time, bleeding amount, and length of hospital stay were 96 min, 50 ml and 4 days, respectively. There was one case of pulmonary infection and one case of persistent air leakage, no death or pulmonary torsion, bronchopleural fistula and other pulmonary complications occurred. After 3 months, the median percentage of lung function retention was 91.7%, and the CT scan showed that the reserved lung tissue of 12 patients was well inflated and there was no obvious imaging manifestation of atelectasis. Conclusion: "Separated" precise subsegmentectomy is a novel and safe surgical method that provides a more optimized way for patients with specific multiple nodules to preserve lung function. Further prospective large studies are needed to verify this finding. [ABSTRACT FROM AUTHOR]

Background: To compare the diagnostic positive rate and complication rate between the electromagnetic navigation bronchoscopy (ENB) technique and computed tomography (CT)‐guided lung puncture for the biopsy of lung nodules located in the middle of an anatomic lung segment. Methods: Electronic medical records of 114 patients who underwent lung nodule biopsy between June 2021 and June 2022 were retrospectively evaluated. In all patients, the nodules were located in the middle third lung segment. To compare the diagnostic positive and complication rates between the two biopsy modalities performed in this lung region, clinical data, complication rates, nodule pathology, and imaging results were reviewed based on nodule characteristics retrieved from the electronic medical records. Results: Ninety‐three patients underwent CT‐guided lung puncture, while the remaining 21 patients underwent the ENB technique. No significant difference was observed in the diagnostic positive rate between the two groups (73.6 and 76.1%, respectively). In the CT‐guided lung puncture group, pneumothorax incidence, tube placement, postoperative hemorrhage, and symptomatic hemorrhage rates were 16.1, 6.5, 6.5, and 1.1%, respectively. In contrast, no complications occurred in the ENB group. Conclusions: The ENB technique is a safe and effective method for performing biopsies of pulmonary nodules with a diagnostic positive rate comparable to that of CT‐guided lung puncture and with a lower postoperative complication rate. [ABSTRACT FROM AUTHOR]

Background and aim: In China, hepatorenal syndrome is a serious complication in the decompensated stage of hepatitis B cirrhosis, which requires early clinical intervention, so the early diagnosis of hepatorenal syndrome is crucial. This study establishes a new predictive model based on serum biomarkers for the early diagnosis of hepatorenal syndrome. Methods: Patients with decompensated hepatitis B cirrhosis who met the inclusion and exclusion criteria were retrospectively enrolled. Patients were randomly assigned to the training dataset and validation dataset at a 7:3 ratio. Univariate and multivariate logistic regression analyses were used to screen the risk factors for hepatorenal syndrome. The identified risk factors were used to establish and verify a model. Results: This study included 255 patients with decompensated hepatitis B cirrhosis, including 184 in the training group and 71 in the validation group. The multivariate logistic regression model was established in the training group and verified in the validation group. Logistic regression showed that hemoglobin (OR 0.938, 95% CI 0.908–0.969), total bilirubin (OR 1.014, 95% CI 1.008–1.021) and creatinine (OR 1.079, 95% CI 1.043–1.117) were independent risk factors for hepatorenal syndrome (P < 0.05). These were used to establish the model. In the training group and the validation group, the area under the ROC curve of the nomogram for the diagnosis of hepatorenal syndrome was 0.968 and 0.980, respectively. Conclusion: The three serum biomarkers, including hemoglobin, total bilirubin and creatinine, can be used as independent early predictors of hepatorenal syndrome in patients with decompensated hepatitis B cirrhosis. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study is to investigate the relationship between physical fitness (PF) level and Chinese middle-school students' perceived well-being, motivation, and enjoyment. Method: In this study, the participants were randomly selected from 16 Beijing-based middle schools in China. In addition to the collection of demographic data (i.e., gender, age, and parental education), tools including the Warwick-Edinburgh Mental Well-Being Scale, the Behavioural Regulation in Sport Questionnaire, and the Physical Activity Children's Enjoyment Scale were employed for collecting data on other variables of well-being, motivation, and enjoyment, respectively. Results: A total of 1678 adolescents (M age = 14.66 years, SD = 1.80) participated in this study. According to the results, significant gender differences could be observed in the PF categories of mean age, BMI, vital capacity, 50-m sprint, muscular strength, and flexibility (all p < 0.05). In contrast, there was no significant gender difference in the levels of well-being, motivation, and enjoyment observed, with similar scores for boys and girls (p > 0.05). Indeed, adolescents with low BMI scores and high levels of vital capacity, muscular strength, and flexibility showed better well-being, motivation, and enjoyment. However, no association was observed between timed sit-ups and pull-ups and well-being, motivation, and enjoyment. Conclusions: This study produced preliminary findings on the relationship between PF and Chinese adolescents' perceived well-being, motivation, and enjoyment. To improve the health of adolescents, it is necessary to adopt prospective and experimental research designs for advocating for fitness education in school-based programs in future research. [ABSTRACT FROM AUTHOR]

We study how pension participation and expected pension benefits affect working-age adults' consumption based on a nationally representative dataset from the China Health and Retirement Longitudinal Study (CHARLS) during the period 2011–2018. We find that the consumption of working-age adults who participate in China's Residents' Basic Pension is 15.4% higher than that of non-participants. Furthermore, we find that if working-age adults' expected pension benefits increase by RMB 1, their consumption will increase by RMB 0.34. Overall, our findings suggest that pension expectations are critical to the consumption decisions of working-age adults and can, therefore, positively affect total domestic consumption. [ABSTRACT FROM AUTHOR]

Impatiens chenmoui (Balsaminaceae), a new species from southern Yunnan, China, was described and illustrated based on morphological and molecular evidence. This new species is morphologically most similar to Impatiens oblongata Ruchis. & Niet, but can be distinguished by 7-9 pairs of leaf veins, glabrous perianth, obovate upper petal, and capsule with trichome. [ABSTRACT FROM AUTHOR]

As the largest groundwater drainage region in China, the per capita water resources in the North China Plain (NCP) account for only one-seventh of the country's available water resources. Currently, the NCP is experiencing a serious water shortage due to the overexploitation of groundwater resources and a subsequent series of natural disasters. Thus, accurate regional assessments and effective water resource management policies are of critical importance. To accomplish this phenomenon, the daily terrestrial water storage anomaly (TWSA) over the NCP is calculated from the combination of the GNSS vertical deformation sequences (seasonal items) and GRACE (trend items). The groundwater storage anomaly (GWSA) in the NCP is obtained by subtracting the canopy water, soil water, and snow water equivalent components from the TWSA. The inversion results of this study are verified by comparisons with the Global Land Data Assimilation System (GLDAS) data products. The elevated annual amplitude areas are located in Beijing and Tianjin, and the Pearson correlation coefficient (PCC), root mean square error (RMSE), and Nash–Sutcliffe efficiency (NSE) between the two GWSA results are 0.67, 4.01 cm, and 0.61, respectively. This indicates that the methods proposed in this study are reliable. Finally, the groundwater drought index was calculated for the period from 2011 to 2021, and the results showed that 2019 was the driest year, with a drought severity index value of −0.12, indicative of slightly moderate drought conditions. By calculating and analyzing the annual GWSA, this work shows that the South–North Water Transfer Project does provide some regional drought mitigation. [ABSTRACT FROM AUTHOR]

Melampsora larici-populina (Mlp), M. medusae (Mmed), M. magnusiana (Mmag), and M. pruinosae (Mpr) are epidemic rust fungi in China. The first two are macrocyclic rust fungi distributed in temperate humid environments. The latter two are hemicyclic rusts, mainly distributed in arid and semi-arid areas. Ontogenetic variation that comes with this arid-resistance is of great interest—and may help us predict the influence of a warmer, drier, climate on fungal phylogeny. To compare the differences in the life history and ontogeny between the two types of rust, we cloned mating type genes, STE3.4 and STE3.3 using RACE-smart technology. Protein structures, functions, and mutant loci were compared across each species. We also used microscopy to compare visible cytological differences at each life stage for the fungal species, looking for variation in structure and developmental timing. Quantitative PCR technology was used to check the expression of nuclear fusion and division genes downstream of STE3.3 and STE3.4. Encoding amino acids of STE3.3 and STE3.4 in hemicyclic rusts are shorter than these in the macrocyclic rusts. Both STE3.3 and STE3.4 interact with a protein kinase superfamily member EGG12818 and an E3 ubiquitin protein ligase EGG09709 directly, and activating G-beta conformational changes. The mutation at site 74th amino acid in the conserved transmembrane domain of STE3.3 ascribes to a positive selection, in which alanine (Ala) is changed to phenylalanine (Phe) in hemicyclic rusts, and a mutation with Tyr lost at site 387th in STE3.4, where it is the binding site for β-D-Glucan. These mutants are speculated corresponding to the insensitivity of hemicyclic rust pheromone receptors to interact with MFa pheromones, and lead to Mnd1 unexpressed in teliospora, and they result in the diploid nuclei division failure and the sexual stage missing in the life cycle. A Phylogenic tree based on STE3.4 gene suggests these two rust types diverged about 14.36 million years ago. Although these rusts share a similar uredia and telia stage, they show markedly different wintering strategies. Hemicyclic rusts overwinter in the poplar buds endophytically, their urediniospores developing thicker cell walls. They form haustoria with a collar-like extrahaustorial membrane neck and induce host thickened callose cell walls, all ontogenetic adaptations to arid environments. [ABSTRACT FROM AUTHOR]

Camellia vietnamensis Huang is an important woody oil crop in China, which has attracted much attention because of its abundant nutritional components and pharmaceutical value. Its seeds undergo a complex series of physiological and biochemical changes during maturation, with consequent alterations in metabolites. In order to investigate the endogenous metabolism of C. vietnamensis on Hainan Island during seed development, in this study, ultra-high-performance liquid tandem chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) and multivariate statistical analysis (MSA) were used to analyze the differences in the chemical compounds of C. vietnamensis seeds among the four maturation stages. A total of 293 metabolites were identified from the methanol extract of the seeds of C. vietnamensis. Five metabolites, belonging to benzene and substituted derivatives, 5′-deoxyribonucleosides and linear 1,3-diarylpropanoids, were found in all three comparison groups, with consistently down-regulated trends. The Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that phloretin and 5′-methylthioadenosine were the differentially expressed metabolites when seeds were in the growth periods of S2 and S3, and indole and L-tryptophan were the differentially expressed metabolites when seeds were in the growth periods of S3 and S4. In addition, 34 flavonoid metabolites were detected, of which 4 were differentially expressed. It was indicated that flavonoids dynamically change during all the oil-tea camellia seed development stages. The findings provide data for the better understanding of endogenous metabolic pathways during C. vietnamensis seed development. [ABSTRACT FROM AUTHOR]

The prevalence of allergic rhinitis (AR) has increased tremendously in the recent year in China. Evidence-based medicine to objectively evaluate the prevalence and risk factors for AR in China is urgently required. Toward this, we systematically searched four English and four Chinese databases to identify the literature on the same, from the year of website establishment until November 2021. A total of 51 studies were evaluated, and data were obtained through Stata 16 analysis. Overall pooled risk factors for adult AR were smoking (odds ratio [OR] = 1.89, 95% confidence interval [CI]: 1.25, 2.87), asthma (OR = 3.30, 95% CI: 1.48, 7.39), a family history of AR (OR = 3.17, 95% CI: 2.31, 4.34), a family history of asthma (OR = 3.99, 95% CI: 2.58, 6.16), drug allergy (OR = 1.62, 95% CI: 1.38, 1.89), food allergy (OR = 2.29, 95% CI: 1.39, 3.78), pollen allergy history (OR = 2.41, 95% CI: 1.67, 3.46), antibiotic use (OR = 2.08, 95% CI: 1.28, 3.36), occupational dust exposure (OR = 2.05, 95% CI: 1.70, 2.47), home renovation (OR = 1.73, 95% CI: 0.99, 3.02), and middle school education (OR = 1.99, 95% CI: 1.29, 3.06). Overall pooled risk factors for AR in children were passive smoking (OR = 1.70, 95% CI: 1.02, 2.82), asthma (OR = 3.26, 95% CI: 2.42, 4.39), a family history of AR (OR = 2.59, 95% CI: 2.07, 3.24), a family history of allergy (OR = 4.84, 95% CI: 3.22, 7.26), a history of allergic diseases (OR = 2.11, 95% CI: 1.52, 2.94), eczema(OR = 2.29, 95% CI: 1.36, 3.85), owning pets (OR = 1.56, 95% CI: 1.37, 1.77), eating seafood (OR = 1.30, 95% CI: 1.10, 1.55), boys (OR = 1.58, 95% CI: 1.43, 1.74), and breastfeeding (OR = 0.82, 95% CI: 0.55, 1.22). The results of our meta-analysis showed that the prevalence of allergy rhinitis was 19% (95% CI 14–25) among adults and 22% (95% CI 17–27) among children, with boys showing a higher prevalence than girls. The development of AR in China is associated with several factors, including allergic diseases (eczema, asthma, pollen allergy, and food allergy), a family history of allergy (AR, asthma, and other allergies), and dwelling and working environment (smoking or passive smoking, occupational dust exposure, and owning pets); conversely, breastfeeding can reduce the risk. [ABSTRACT FROM AUTHOR]

Since the formal accession to the Washington Accord, the cultivation of the ability to solve complex engineering problems has become the focus of China's undergraduate engineering education. Because complex engineering problems are innovative, it is necessary to study the effect of TRIZ teaching on the cultivation ofthe ability to solve complex engineering problems. However, there are few studies on the effect of TRIZ on the cultivation of ability to solve complex engineering problems. Taking China's civil engineering major as an example, based on the network questionnaire, this paper investigates the ability of 1532 junior and senior students to solve complex engineering problems at four universities. The findings were that the ability of the surveyed students to solve complex engineering problems needs to be improved, especially their ability in the areas of engineering design. problem identification and problem analysis. At present, the cultivation of systematic thinking in China's engineering education is also inadequate. Normative research, course teaching and graduation design were used to verify the effectiveness of TRIZ in training Chinese civil engineering students' ability to solve complex engineering problems. Based on the text analysis of students' course reports and graduation designs, combined with the results of students' self-assessment questionnaires and TRIZ expert interviews, the results indicate that TRIZ can effectively cultivate students' ability to solve complex engineering problems, especially problem identification, problem analysis and innovative thinking. This paper provides guidance for further exploring the cultivation of the ability to solve complex engineering problems and for the integration of innovative methods and professional education. [ABSTRACT FROM AUTHOR]

Karst rocky desertification is a common phenomenon in terrestrial ecosystems, and the deterioration of soil quality has a serious side effect on the aboveground vegetation and underground environmental factors. To clarify the variety of soil quality in different rocky desertification grades in typical karst areas of southwest China, the soil quality of four rocky desertification grades was calculated by a single model (SQI: soil quality index), two screening processes (TDS: total dataset and MDS: minimum dataset) and three scoring methods (SSF: standard scoring function, SL: linear scoring function and SNL: nonlinear scoring function). The key results are as follows: Significant differences were found in the soil environment factors in non-rocky desertification (NRD), light rocky desertification (LRD) and moderate rocky desertification (MRD) as compared to intense rocky desertification (IRD) (p < 0.01). Except for total potassium (TK), manganese (Mn) and amylase, the other soil environmental factors showed U-shaped changes. In contrast, TK, Mn and amylase increased first and then decreased. Additionally, the SQI based on MDS in SSF, SL and SNL was IRD (0.58) > NRD (0.48) > LRD (0.45) > MRD (0.43), IRD (0.53) > NRD (0.42) > LRD (0.39) > MRD (0.36) and IRD (0.57) > NRD (0.47) > MRD (0.42) > LRD (0.40), respectively. However, the SQI was always in the trend of IRD > NRD > MRD > LRD based on the TDS. Overall, although the soil area is scarce, the edaphic properties, enzyme activities and soil quality are not poor in the IRD. Furthermore, we found that SNL was more suitable for the evaluation of soil quality in the karst rocky desertification area (R2 = 0.63, p < 0.001 and the coefficient of variation = 30.69%). This research helps to clarify the variation in soil properties and quality during the succession of rocky desertification and provides guidelines for the sustainable management of soil quality in areas of southwest China. [ABSTRACT FROM AUTHOR]

Introduction: Large artery intracranial occlusive disease including middle cerebral artery (MCA) is a major contributor to the incidence of stroke in China. The data on the prognosis of symptomatic atherosclerotic MCA occlusions (MCAO) are limited. We aimed to investigate the related factors of unfavorable outcomes in patients with stroke associated with MCAO.Material and methods: A total of 119 patients with MCAO symptom were enrolled in this retrospective longitudinal cohort study. All patients met inclusion criteria of cerebral angiography by CT angiography or magnetic resonance angiography. Stroke severity was assessed on admission using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS).Results: We showed an average follow-up time of 46.8 months, within which 20 (19.6%) cases died and 14 (13.7%) cases had stroke recurrence. Using mRS as an evaluation index, the patients were divided into an unfavourable outcome group (mRS > 2, 48 cases) and a favourable outcome group (mRS ≤ 2, 54 cases). Logistic regression analysis suggests that age and NIHSS score were independent risk factors for a poor outcome value. Coexisting other cerebral vascular occlusion was an independent risk factor for stroke recurrence. Age was an independent risk factor for death.Conclusions: The prognosis of patients with MCAO was generally optimistic, with higher survival rate and longer survival time. As compared, elder age and higher NIHSS score both tend to be associated with worse prognosis of survival. MCAO patients with other extracranial or intracranial vascular occlusion have higher risk of recurrent stroke. Death rate increases with age among the MCAO patients. [ABSTRACT FROM AUTHOR]

This paper reviews the characteristics of leachate produced from municipal solid waste landfills, incineration plants, transfer stations, and food waste anaerobic fermentation plants. In addition, the development of the leachate treatment technology used in China is investigated. The development period of leachate treatment technology in China can be divided into five stages: the early 1990s with simple biological treatment, the mid-to-late 1990s with ammonia stripping + anaerobic + aerobic treatment, from 2000 to 2008 with a two-stage disc tube reverse osmosis (DT-RO) process, from 2008 to 2015 with an anaerobic + aerobic + advanced treatment process, and from 2015 until the present with a diversified and full quantitative process. Furthermore, under the requirements of ecological environmental protection and "dual carbon" development concepts, this paper advises the future development trend of Chinese municipal solid waste leachate, which will enact more scientific emission standards and local standards, become inevitable for the green ecology of the technical route, be more professional and intelligent for construction and operation, and diversify resource utilization of the treatment facilities process. [ABSTRACT FROM AUTHOR]

Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan (5-HTP) → serotonin (5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan; meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation, and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood–brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide, as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. Up-regulating gut microbiota tryptophan hydroxylase levels and down-regulating 5-hydroxytryptophan decarboxylase activity is the molecular mechanism of action of the anti-depressant drug Morinda officinalis oligosaccharides. [Display omitted] [ABSTRACT FROM AUTHOR]

Since the 2000s, there has been an increasing number of returning and migrant farmers across China. In 2012, China initiated a program for fostering professional farmers, which has caused greater changes for farmers and led to an agricultural shift towards commercial production. Migration has been recognized as a crucial factor affecting the diversity of agricultural production. However, scant attention has been paid to how different types of farmers influence agricultural diversification. Therefore, this study examines the influence of migrant farmers, returning farmers, and local non-migrant farmers on food production diversity. This study collected farm-level data on food production and farmers' characteristics and applied a negative binomial regression model to estimate the impacts of different types of farmers on agricultural development. The results show that farms operated by migrant farmers had a significantly lower level of food production diversity while farms operated by returning farmers had no significant difference in food production diversity, using farms operated by local non-migrant farmers as the reference category. The variation in agricultural production diversity lies in differences in food production purposes, agricultural and market skills, and various risk-related capacities among the different types of farmers. Farm-level production specialization does not necessarily reduce food diversity and agrobiodiversity at the rural community and regional level. • Program for Cultivating New-type Professional Farmers has been implemented for agriculture commercialisation in China. • Migrant farmers tend to prefer specialized farming while returning farmers prefer diversification. • Specialized agricultural production has not reduced the diversity of regional food production. [ABSTRACT FROM AUTHOR]