1. Australeols A−F, neuroprotective meroterpenoids from Ganoderma australe.
- Author
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Zhang, Jiao-Jiao, Dong, Yun, Qin, Fu-Ying, and Cheng, Yong-Xian
- Subjects
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ANALYSIS of variance , *CELL lines , *CRYSTALLOGRAPHY , *FUNGI , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *RESEARCH funding , *SPECTRUM analysis , *STATISTICS , *T-test (Statistics) , *TERPENES , *DATA analysis , *NEUROPROTECTIVE agents , *PHARMACODYNAMICS - Abstract
Six new meroterpenoids, australeols A−F (1 – 6), together with nineteen known compounds (7 – 25), were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods, CD comparison, and X-ray crystallography analysis. Biological evaluation reveals that compounds 13 , (–)- 19 , and 23 exhibit potent neuroprotective activities in glutamate-stimulated SH-SY5Y cells. Unlabelled Image [ABSTRACT FROM AUTHOR]
- Published
- 2019
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