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1. Unequal crossing-over: a common basis of single alpha-globin genes in Asians and American blacks with hemoglobin-H disease.

Author

Phillips JA 3rd, Vik TA, Scott AF, Young KE, Kazazian HH Jr, Smith KD, Fairbanks VF, and Koenig HM

Subjects
Black People, China, Chromosome Deletion, DNA Restriction Enzymes, Humans, Philippines, Thalassemia genetics, Black or African American, Crossing Over, Genetic, Genes, Globins genetics, Hemoglobin H genetics, Hemoglobins, Abnormal genetics
Abstract

The alpha-globin genes of five black Americans, two Chinese, and five Filipinos with HbH disease (an alpha-thalassemia state in which there is a single functional alpha gene) were analyzed by restriction endonuclease techniques. All subjects were found to have one chromosome 16, lacking both alpha genes, and another containing a single alpha gene (--/-alpha). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single alpha gene in these individuals.

Published
1980

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