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China has made huge efforts to increase the efficiency of its resources and change its resource-intensive economic trajectory. A question which should be raised is whether the impacts of such shifts can be measured. Exergy analysis provides a unified method of ecological diagnosis of resource allocation and metabolism in social systems from a biophysical perspective. This paper explores the resource utilization pattern within Chinese society by employing an exergy-based accounting method. Nationally total resource consumption amounted to 153.7 EJ in 2017, and non-biological resources reached 137.1 EJ. China's resource self-sufficiency rate was revealed as 79.1%. After China experienced a transition period with a medium–high economic growth rate, the total net resource input into Chinese society marked an increase of around 1% from 2012 to 2017. The per capita resource consumption dropped from 112.0 GJ in 2012 to 110.6 GJ in 2017. The proportion of resource exergy consumption in the tertiary sector was upregulated from 10.0% in 2012 to 17.6% in 2017. To be specific, the exergy conversion efficiency of the domestic sector rose from 1.3% in 2012 to 20.6% in 2017. The results confirm that the resource exergy utilization structures and the conversion efficiencies of the main social sectors in China's economic transition period were significantly optimized towards a more sustainable future. A reasonable analysis of the resource exergy utilization pattern provides a solid reference for assessing the comprehensive effect of the changed development speed, industrial structure, and driving force of a developing society. [ABSTRACT FROM AUTHOR]

Severe acute diarrhea syndrome coronavirus (SADS-CoV) was first detected in Guangdong province of China in 2017. And yet from May 2021 to Jun 2023, there were no SADS-CoV outbreaks. In this study, we reported the recent outbreak of SADS-CoV in China on Jun 2023. Phylogenetic analysis showed the novel strain was derived from the ongoing transmission and evolution of SADS-CoV in China, rather than a separate cross-species transmission from bats. Also, the novel strain was found to participate in a recombant event as a minor parent and a missing base in the genome was discovered indicating an novel evolutionary pathway. Through virulence assays in piglets, we further determined that novel strain (SADS-CoV/HNNY/2023) was a highly virulent SADS-CoV strain with typical clinical symptoms: acute diarrhea, vomiting, rapid weight loss. Therefore, the re-emergence of SADS-CoV strains should be brought to people's attention. • We report the first re-appearance of SADS-CoV since 2021. • This is the first outbreak of SADS-CoV in inland China. • The novel strain was derived from the ongoing transmission and evolution of SADS-CoV. • The novel strain (SADS-CoV/HNNY/2023) was a highly virulent SADS-CoV strain. [ABSTRACT FROM AUTHOR]

The objective of this research was to evaluate and compare the pharmacokinetic profiles and safety of lisinopril/hydrochlorothiazide (10 mg/12.5 mg) tablets in the test and reference formulations administered to participants in both fasting and postprandial states and to evaluate the bioequivalence of the 2 products in healthy Chinese volunteers. This study employed a single-center, randomized, open-label, single-dose dosing trial involving a cumulative 96 healthy adult participants (60 in the fasting group and 36 in the postprandial group). Each group comprised 2 sequence sets, and a 2-week washout period was implemented. There were no statistically significant differences in time to maximum concentration and terminal elimination half-life between the test and control groups under fasting and postprandial conditions (P > .05), and the 90% CIs for area under the plasma concentration-time curve and maximum plasma concentration were within the bioequivalence range of 80%-125%. Pharmacokinetic results indicate a large food effect for lisinopril, meaning that there is a loss of approximately 20%-25% of systemic exposure from fasting to postprandial administration for both preparations. The study demonstrated that a single oral dose of generic lisinopril/hydrochlorothiazide is bioequivalent to the reference product and well tolerated, with no significant adverse events observed, and that both products are similarly safe in a cohort of healthy Chinese male and female participants, following administration under fasting and postprandial conditions., (© 2023, The American College of Clinical Pharmacology.)

China's trade of agricultural products has expanded rapidly over the past two decades, resulting in considerable shifts in greenhouse gas (GHG) emissions worldwide. This study aims to explore the evolution of GHG emissions embodied in China's trade of agricultural products from 1995 to 2015. The GHG emissions embodied in China's exports of agricultural products experienced three stages of fluctuation, showing a significant upward trend (1995-2003), a fluctuating trend (2004-2007), and a fall back to the previous level (2008-2015). The embodied GHG emissions in China's imports were witnessed at times of sustained growth, rising from 10.5 Mt CO 2 -eq in 1995 to 107.7 Mt CO 2 -eq in 2015. The net import of embodied GHG emissions has grown at an average annual rate of 25.1% since 2008. In terms of regional contribution, the distribution of China's trading partners tended to be diversified. The increasing net imports of oil crops to China resulted in a significant GHG emissions shift from China to the US and Brazil. Asian countries contributed to 76.9% of the total GHG emissions embodied in China's agricultural exports. The prominent impacts of China's trade of agricultural products on global GHG emissions provide important implications for climate-related policy choices.