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Abstract: Perfluorooctane sulfonic acid (PFOS) could be commonly detected in water bodies around many cities in China recently, which mainly comes from the industrial production and utilization in the fabric processing, metal plating, semiconductor manufacturing and fire-fighting foam. China is currently one of the few countries with increasing PFOS production and usage, so the treatment and safe disposal of PFOS pollutants is critical to effectively protect human health from those toxic chemicals. Life cycle assessment (LCA) by Simapro 7.2 was carried out in this paper to study the environmental impacts concerned with the treatment of PFOS in supercritical water, and proven process for the decomposition of PFOS pollutants with high concentration. This study focuses on not only the main environmental factors from emissions of toxic pollutants, but also the influence from technical characteristics of the iron-induced supercritical water technology including energy and substances consumption during treatment processes. The results of LCA were supposed to be provided for the environmental officials and factory managers as a theoretical basis for the PFOS technology selection and management. [Copyright &y& Elsevier]

Background: Whether and to what extent multiple healthy lifestyles affect the longevity of people with disabilities, including those in basic activities of daily living, mobility, vision, hearing and cognition, is crucial to policymakers. We aimed to determine the impact of combined lifestyles on life expectancy (LE) lived with and without five disabilities., Methods: We recruited participants (n = 15 121 from the China Longitudinal Healthy Longevity Survey between 2008 and 2018. Healthy lifestyle levels were estimated from six factors: smoking, drinking, physical exercise, diet, cognitive activity, and sleep, which we categorised as favourable and unfavourable using the latent class growth mixture model throughout the follow-up period. We used Multi-state Markov models to assess the different disability stages of LE., Results: Of the total LE at age 65, older adults with a favourable lifestyle spent 59.60% (disability-free LE (DFLE) = 10.24 years) without five disabilities in combination, whereas those with unfavourable lifestyle spent 56.74% (DFLE = 7.28 years). Furthermore, the percentage of DFLE was 64.98 (7.71 years) and 68.38 (9.91 years) in males with unfavourable and favourable lifestyle levels, respectively, and 47.92 (6.62 years) and 55.12 (10.30 years) for females. Compared to older adults with low socioeconomic status (SES) and unfavourable lifestyle level, those with lower SES and favourable lifestyle level had more 3.77 years of DFLE, those with higher SES and unfavourable lifestyle level had more 1.94 years, as well as those with higher SES and favourable lifestyle level had more 5.10 years at age 65. Corresponding associations were found separately for each of the five individual disabilities., Conclusions: A favourable lifestyle level was associated with longer total LE along with a higher proportion of DFLE and may contribute to narrowing socioeconomic health inequalities. Policymakers should develop lifestyle interventions and scale up rehabilitation services in primary care, thereby delaying disabilities to later ages, especially in low- and middle-income countries., Competing Interests: Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests., (Copyright © 2024 by the Journal of Global Health. All rights reserved.)

Background: Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population., Methods: Here we investigated the association between genetic variants in three calcium signaling pathway genes ( CACNB2 , CACNA1C and CACNA1I ) and SCZ in 1615 SCZ cases and 1597 controls., Results: A single nucleotide polymorphism (SNP) (rs4522708) in CACNA1I is significantly associated with SCZ in our Chinese sample (OR A allele  = 1.19, corrected P  = 0.042), suggesting that CACNA1I may also be a risk gene for SCZ in Chinese population. Of note, the risk allele (A allele) of SNP rs4522708 is same in European and Chinese populations. Meta-analysis of Chinese and European samples further strengthened the association of rs4522708 with SCZ (OR A allele  = 1.074, P  = 6.26 × 10 -11 ). Expression analysis showed that CACNA1I was significantly up-regulated in hippocampus of SCZ cases compared with controls, implying that dysregulation of CACNA1I may have a role in schizophrenia pathogenesis., Conclusions: Our study suggests that CACNA1I is a risk gene for SCZ in Chinese population and provides further evidence that supports the potential role of neuronal calcium signaling in schizophrenia., Competing Interests: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.