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Nowadays, extensive research has been conducted to generate electricity from ocean waves, but there are not too many studies on the capture of wave energy in a specific ocean area. As the largest sea area in China's offshore waters, the South China Sea contains a large amount of wave energy and is regarded as a natural wave energy power plant. A comparative study was conducted to investigate the effects of wave energy converter (WEC) parameters on the long-term power capture performance of a bistable point absorber WEC installed in the South China Sea in this paper. Combined with the joint probability distribution of significant wave height H s and peak wave period T p in South China Sea, a mathematical model was developed for the evaluation of long-term power performance of WECs. The governing equations of the point absorber WEC were established using the hybrid frequency-time domain method. The dynamic response and captured power can be obtained after numerically solving the equations of motion with the 4th order Runge-Kutta Method. The results show that the bistable mechanism has great advantages in the long-term captured power of WEC. In general, a circular truncated cone-shaped buoy WEC with a larger buoy size and smaller nonlinear parameter tend to result in better long-term power capture performance. The insights given in this study provide a motivation and foundation for developing a complete set of performance optimization methods of point absorber WECs installed in South China Sea. • A mathematical model was developed for evaluation of long-term power performance of a point absorber WEC (PAWEC). • The long-term power performance of the WECs with and without bistable mechanism was numerically simulated. • The advantages of the bistable mechanism in the long-term captured power of WEC were confirmed. • The effects of WEC parameters on the long-term performance of the PAWEC were clarified. [ABSTRACT FROM AUTHOR]

Purpose: Metastatic prostate cancer (PCa) has become a major obstacle in the treatment of PCa. The study's purpose is to find biomarkers of tumor metastasis by proteomics and enzyme-linked immunosorbent assay (ELISA), and to design related experiments to study its role in the progress and metastasis of PCa. Method: We analyzed serum from primary PCa stage and metastatic stage of 12 patients to find metastatic PCa serum protein biomarkers using isobaric tags for relative and absolute quantitation (iTRAQ). An effective diagnostic model based on validated biomarkers using logistic regression was established. In vivo and in vitro biological behavior experiments (wound healing, CCK8, and Transwell tests) were carried out after obtaining the biomarkers. Related mechanism has been studied, which may be associated with metastatic PCa. Result: Actin gamma 1 ( ACTG1 ) is a potential biomarker in the metastasis of PCa. Bioinformatics and related experiments show that ACTG1 is high-expressed in PCa tissues and cells. In vivo and in vitro experiments illustrated that the ability of proliferation, migration, and invasion of PCa cells was significantly inhibited after the knockdown of ACTG1 expression. Surprisingly, ERK protein expression was downregulated after ACTG1 knockdown. At the same time, the expression of epithelial-mesenchymal transition-related markers in PCa cells decrease after treated with ERK1/2 inhibitor, which indicating that ACTG1 may affect the metastatic ability of PCa cells through MAPK/ERK signaling pathway. Conclusion: ACTG1 is a marker of metastasis PCa. It mediates cell proliferation and may regulate the metastasis of PCa through MAPK/ERK signaling pathway, which provides a useful theoretical basis for exploring the treatment of PCa.