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This article reports the findings of a small-scale, follow-up investigation into the transfer problems encountered by first-year teachers in China, and the interactions that emerged among the teachers' preconceptions of teaching, university teacher preparation programmes and teaching school contexts in their first year. Participants were surveyed both pre-graduation, after finishing their teaching practice in Year 4 of their B.Ed. programme and after their first year of teaching, when the transfer problem was newly emerged. This study finds that first-year teachers were not challenged solely by transfer problems emerging from differences among their preconceptions of teaching, university teacher preparation programmes and teaching school contexts, but also by the lack of learning support they had when teaching in the wider, radical changing social context. This study gives voice to the perceived learning needs and related supports of first-year teachers in China.

Achieving the goals of "carbon peaking" and "carbon neutrality" becomes one of the important elements of the ecological civilization strategy in China. Based on the strong balanced panel data of 281 prefecture-level cities in China from 2006 to 2019, we investigate the impact of Low-carbon city pilot policy (LCCP policy) on FDI inflows by using the multi-period DID model and intermediary model. After that, we discuss the heterogenous impact in terms of both policy tools and geographic locations. Furthermore, we investigate the spillover effects of the LCCP policy on the FDI inflows of surrounding cities using the Spatial Dubin DID model. The results show that (1) the LCCP policy can significantly attract FDI through reducing compliance costs and promoting technological innovation, and the Bacon decomposition and the placebo test show that the estimation error is small and the regression result is relatively stable; (2) command-mandatory tools have negative effects on FDI, while market-oriented tools can effectively attract FDI in pilot cities, but voluntary tools have no significant effect on FDI in pilot cities; (3) the LCCP policy can significantly promote the inflows of FDI in the eastern and western regions, but it does not significantly promote the FDI in central regions; (4) there is a positive spillover effect on FDI inflows to surrounding cities. [ABSTRACT FROM AUTHOR]

The coexistence of mcr-1 and blaNDM-5 in the plasmid of Escherichia coli has been widely reported and such strains have been mainly isolated from animal and human feces. However, few reports have focused on the genetic diversity of mcr-1-carrying chromosomes and blaNDM-5-carrying plasmids in E. coli isolates from lesion-bearing animal organs. This study investigated the genetic characteristics of chromosome-mediated mcr-1 and plasmid-mediated blaNDM-5 in E. coli isolated from lesion-bearing animal organs. Nine mcr-1-and blaNDM-5- positive E. coli strains (MNPECs) showed extensive drug resistance (XDR). The predominant clonal complexes (CC) mainly belonged to CC156, CC10, and CC165 from the 56 MNEPCs (including nine strains in this study) retrieved from the literature. These strains were widely distributed in China, and originated from pig fecal samples, human stool/urine samples as well as intestinal contents of chicken. Two transconjugants harboring blaNDM-5 gene were also successfully obtained from two donors (J-8 and N-14) and this transfer increased the MIC for meropenem by 256 times. However, conjugative transfer of mcr-1 gene failed. Both J-8 and N-14 strains contained point mutations associated with quinolone resistance and more than three types of AMR genes, including the mcr-1 gene on the chromosome and the blaNDM-5 gene on the IncX3-type plasmid. The genetic structure of mcr-1 located on the chromosome was an intact Tn6330, and blaNDM-5-carrying IncX3-type plasmid was ISAb125-IS5-blaNDM-5-bleO-trpF-tat-cutA-IS26 gene cassette. Moreover, differences between chromosomes included additional partial sequence of phage integrated into host genome and the different genes associated with O-antigen synthesis. [ABSTRACT FROM AUTHOR]

Study Question: Can new genetic factors responsible for male infertility be identified, especially for those characterized by asthenospermia despite normal sperm morphology?Summary Answer: We identified the novel pathogenetic gene IQ motif and ubiquitin-like domain-containing (IQUB) as responsible for male infertility characterized by asthenospermia, involving sperm radial spoke defects.What Is Known Already: To date, only a few genes have been found to be responsible for asthenospermia with normal sperm morphology. Iqub, encoding the IQUB protein, is highly and specifically expressed in murine testes and interacts with the proteins radial spoke head 3 (RSPH3), CEP295 N-terminal like (CEP295NL or DDC8), glutathione S-transferase mu 1 (GSTM1) and outer dense fiber of sperm tails 1 (ODF1) in the yeast two-hybrid system.Study Design, Size, Duration: The IQUB variant was identified by whole-exome sequencing in a cohort of 126 male infertility patients with typical asthenospermia recruited between 2015 and 2020. Knockout (KO) and knockin (KI) mouse models, scanning and transmission electron microscopy (TEM), and other functional assays were performed, between 2019 and 2021.Participants/materials, Setting, Methods: The IQUB variant was identified by whole-exome sequencing and confirmed by Sanger sequencing. Iqub KO and KI mice were constructed to mimic the phenotype of the affected individual. After recapitulating the phenotype of human male infertility, scanning and TEM were performed to check the ultrastructure of the sperm. Western blot and co-immunoprecipitation were performed to clarify the pathological mechanism of the IQUB variant.Main Results and the Role Of Chance: We identified a homozygous nonsense IQUB variant (NM_001282855.2:c.942T> G(p.Tyr314*)) from an infertile male. Iqub KO and KI mice mimicked the infertility phenotype and confirmed IQUB to be the pathogenetic gene. Scanning and TEM showed that sperm of both the mouse models and the affected individual had radial spoke defects. The functional assay suggested that IQUB may recruit calmodulin in lower Ca2+ environments to facilitate the normal assembly of radial spokes by inhibiting the activity of RSPH3/p-ERK1/2 (a nontypical AKAP (A-Kinase Anchoring Protein) forming by RSPH3 and phosphorylation of extracellular signal-regulated kinase 1 and 2 (p-ERK1/2)).Limitations, Reasons For Caution: Additional cases are needed to confirm the genetic contribution of IQUB variants to male infertility. In addition, because no IQUB antibody is available for immunofluorescence and the polyclonal antibody we generated was only effective in western blotting, immunostaining for IQUB was not performed in this study. Therefore, this study lacks direct in vivo proof to confirm the effect of the variant on IQUB protein level.Wider Implications Of the Findings: Our results suggest a causal relation between IQUB variants and male infertility owing to asthenospermia, and partly clarify the pathological mechanism of IQUB variants. This expands our knowledge of the genes involved in human sperm asthenospermia and potentially provides a new genetic marker for male infertility.Study Funding/competing Interest(s): This work was supported by the National Key Research and Development Program of China (2021YFC2700100), the National Natural Science Foundation of China (32130029, 82171643, 81971450, 82001538, and 81971382) and the Guangdong Science and Technology Department Guangdong-Hong Kong-Macao Joint Innovation Project (2020A0505140003). There are no competing interests to declare.Trial Registration Number: N/A. [ABSTRACT FROM AUTHOR]

Study Question: Do distinct subpopulations of decidual stromal cells (DSCs) exist and if so, are given subpopulations enriched in recurrent miscarriage (RM)?Summary Answer: Three subpopulations of DSCs were identified from which inflammatory DSCs (iDSCs) and glycolytic DSCs (glyDSCs) are significantly enriched in RM, with implicated roles in driving decidual inflammation and immune dysregulation.What Is Known Already: DSCs play crucial roles in establishing and maintaining a successful pregnancy; dysfunction of DSCs has been considered as one of the key reasons for the development of RM.Study Design, Size, Duration: We collected 15 early decidual samples from five healthy donors (HDs) and ten RM patients to perform single-cell RNA sequencing (scRNA-seq). A total of 43 RM patients and 37 HDs were enrolled in the validation cohort.Participants/materials, Setting, Methods: Non-immune cells and immune cells of decidual tissues were sorted by flow cytometry to perform scRNA-seq. We used tissue microarrays (TMA) to validate three distinct subpopulations of DSCs. The expression of inflammatory and glycolytic proteins by DSCs was validated by immunohistochemistry (IHC) and multiplex immunohistochemistry (mIHC). Different subsets of decidual NK (dNK) cells and macrophages were also validated by multicolor flow cytometry and mIHC. Cell ligand-receptor and spatial analyses between DSCs and immune cells were analyzed by mIHC.Main Results and the Role Of Chance: We classify the DSCs into three subtypes based on scRNA-seq data: myofibroblastic (myDSCs), inflammatory (iDSCs) and glycolytic (glyDSCs), with the latter two being significantly enriched in RM patients. The distribution patterns of DSC subtypes in the RM and HD groups were validated by mIHC. Single-cell analyses indicate that the differentiation of iDSCs and glyDSCs may be coupled with the degrees of hypoxia. Consequently, we propose a pathological model in which a vicious circle is formed and fueled by hypoxic stress, uncontrolled inflammation and aberrant glycolysis. Furthermore, our results show that the inflammatory SPP1+ macrophages and CD18+ dNK cells are preferentially increased in the decidua of RM patients. Cell ligand-receptor and mIHC spatial analyses uncovered close interactions between pathogenic DSCs and inflammatory SPP1+ macrophages and CD18+ NK cells in RM patients.Large Scale Data: The raw single-cell sequence data reported in this paper were deposited at the National Omics Data Encyclopedia (www.biosino.org), under the accession number OEP002901.Limitations, Reasons For Caution: The number of decidual samples for scRNA-seq was limited and in-depth functional studies on DSCs are warranted in future studies.Wider Implications Of the Findings: Identification of three DSC subpopulations opens new avenues for further investigation of their roles in RM patients.Study Funding/competing Interest(s): This study was supported by the Strategic Priority Research Program (No. XDB29030302), Frontier Science Key Research Project (QYZDB-SSW-SMC036), Chinese Academy of Sciences; National Key Research and Development Program of China (2021YFE0200600), National Natural Science Foundation of China (No. 31770960), Shanghai Municipal Science and Technology Major Project (No. 2019SHZDZX02, HS2021SHZX001), and Shanghai Committee of Science and Technology (17411967800). All authors report no conflict of interest. [ABSTRACT FROM AUTHOR]

Aims: Available evidence is incomplete and inconsistent in the outcomes of heart failure (HF) patients with preserved ejection fraction (HFpEF), mildly reduced ejection fraction (HFmrEF), and reduced ejection fraction (HFrEF). There are also limited data on the proportions and long‐term prognosis among the three HF phenotypes in China. We aimed to characterize the 5 year prognosis in three HF phenotypes according to EF in a cohort of hospitalized HF patients undergoing coronary angiography in southern China. Methods and results: Hospitalized patients with HF were enrolled from the Cardiorenal ImprovemeNt registry (CIN; ClinicalTrials.gov NCT04407936) between January 2007 and December 2014. HF phenotypes were defined as HFpEF (EF ≥ 50%), HFmrEF (EF 41–49%), and HFrEF (EF ≤ 40%). Kaplan–Meier and Cox proportional hazards models were constructed to examine differences in 5 year outcomes in HF patients with different phenotypes. A total of 4880 HF patients [mean age: 61.8 ± 10.3, male: 3156 (64.7%)] were included: 2768 (57%) had HFpEF, 1015 (21%) had HFmrEF, and 1097 (22%) had HFrEF. Patients with HFrEF were older than those with HFpEF (62.5 ± 10.6 vs. 61.3 ± 10.1, P < 0.001) and more likely to be male (78.0% vs. 55.9%, P < 0.001). With 5 year follow‐up through the end of December 2019, 1624 (27.6%) patients died. Controlling confounding variables, declined EF category was independently associated with increased 5 year mortality {HFrEF 25.2% vs. HFpEF 13.4%, adjusted hazard ratio [aHR]: 1.85 [95% confidence interval (CI): 1.45 to 2.35]; HFmrEF 18.1% vs. HFpEF 13.4%, aHR: 1.40 [95% CI: 1.08 to 1.81]; HFrEF 25.2% vs. HFmrEF 18.1%, aHR: 1.32 [95% CI: 1.02 to 1.71]}. Conclusions: In this Chinese cohort, patients with HFrEF account for less than a fourth of HF patients. One‐sixth individuals with HF died in 5 years. HFrEF was associated with a nearly two‐fold increased risk of 5 year mortality than HFpEF. Further studies are needed to prospectively evaluate the efficacy of improving treatment on outcomes in all three HF phenotypes. [ABSTRACT FROM AUTHOR]

We aimed to explore the association between the number of primary healthcare workers and infectious diarrhea morbidity at community levels and to provide evidence-based implications for optimizing primary healthcare manpower resource allocations. We collected annual infectious diarrhea morbidity and relevant data of 4321 communities in Sichuan Province, China, from 2017 to 2019. Global and local Moran's I were calculated to detect the spatial clustering of infectious diarrhea morbidity and to identify areas where increased primary healthcare manpower resources should be allocated. The spatial lag fixed effects panel data model was adopted to explore the association between the number of primary healthcare workers per 1000 residents and infectious diarrhea morbidity. Significantly high–high and low–low clusters of infectious diarrhea cases were found to be mainly distributed in underdeveloped and developed areas during the studied period years, respectively. The infectious diarrhea morbidity was found to be statistically negatively associated with the number of primary healthcare workers per 1000 residents with a coefficient of − 0.172, indicating that a 0.172 reduction of infectious diarrhea morbidity (1/10,000) was associated with doubled amounts of primary healthcare workers per 1000 residents. Our findings highlighted the role of primary healthcare in the process of infectious diarrhea prevention and control, and implied that constant efforts should be addressed to facilitate infectious diarrhea prevention and control, especially in the underdeveloped areas. [ABSTRACT FROM AUTHOR]

Limited land resources are used to meet the growing economic, social, and ecological needs of people in China. Food, energy, and water (F-E-W) are the basic resources for supporting human survival and the transformation of different land uses. This paper tries to construct a theoretical framework of land use and the F-E-W nexus and uses system dynamics to simulate the optimal allocation of land use in Shizuishan City, China, by comparing different scenarios that have different parameters related to F-E-W. The final results follow: (1) according to the relationship between land use and the F-E-W nexus, a three-layer nested theoretical framework is constructed. (2) Future land use under different scenarios differs. Under the scenarios of a less dependence on coal energy, a higher utilization efficiency of energy and agricultural water resources, and a lower grain selfsufficiency rate, there are less crop and urban lands but more ecological land. However, generally speaking, crop and rural construction lands tend to decrease, while urban and ecological lands tend to increase. (3) Combined with different objectives, the rapid transformation scenario is considered a better option in which to achieve a balance among the economy, society, and ecology. This paper also discusses the application of land use optimization in the delineation of three control lines in territory-space planning in China. [ABSTRACT FROM AUTHOR]

In recent years, the inland river shipping industry in China has been facing the pressure to comply with 'low carbon shipping' policies. Solar energy as one of the most widely used new energy sources has attracted more and more attention in the shipping industry. In 2015, the researchers from Wuhan University of Technology have successfully applied solar energy in an inland river 800PCC (Pure Car Carrier) – 'Anji204'. The present article described the photovoltaic (PV) generation system which was installed on board the ship and reported the results of actual navigation trials on the testing leg, Yangtze River. On the basis of the collected data, the main research purpose is to evaluate the greenhouse gas (GHG) emission and fuel consumption after introduced solar energy into ship energy system by using Energy Efficiency Design Index (EEDI) analysis. The results show that the ship EEDI reduced from 55.09 g_CO2/ton·nmile to 52.02 g_CO2/ton·nmile, decreased by about 5.57%. In addition, it can reduce the fuel consumption by an average about 16 tons per year. Therefore, the utilisation of solar energy in ships can help the inland river shipping industry to meet the 'low carbon shipping' policies. [ABSTRACT FROM AUTHOR]

The green development of coastal urban agglomerations, which are strategic core areas of national economic growth in China, has become a major focus of both academics and government agencies. In this paper, China's coastal urban agglomeration is taken as the research area, aiming at the serious air pollution problem of coastal urban agglomeration, geographic information system (ArcGIS10.2) spatial analysis and the spatial Dubin model were applied to National Aeronautics and Space Administration atmospheric remote sensing image inversion fine particulate matter (PM2.5) data from 2010–2016 to reveal the temporal and spatial evolution characteristics and Influence mechanism of PM2.5 in China's coastal urban agglomerations, with a view to providing a reference value for coordinating air pollution in the coastal cities of the world. From 2010–2016, the PM2.5 concentration in China's coastal urban agglomerations decreased as a whole, and large spatial differences in PM2.5 concentration were observed in China's coastal urban agglomerations; the core high-pollution areas were the Beijing–Tianjin–Hebei, Shandong Peninsula, and Yangtze River Delta urban agglomerations. Large spatial differences in PM2.5 concentration were also observed within individual urban agglomerations, with higher PM2.5 concentrations found in the northern parts of the urban agglomerations. Significant spatial autocorrelation and spatial heterogeneity were observed among PM2.5-polluted cities in China's coastal urban agglomerations. The northern coastal urban agglomerations formed a relatively stable and continuous high-pollution zone. The spatial Dubin model was used to analyze the driving factors of PM2.5 pollution in coastal urban agglomerations. Together, meteorological, socioeconomic, pollution source, and ecological factors affected the spatial characteristics of PM2.5 pollution during the study period, and the overall effect was a mixed effect with significant spatial variation. Among them, meteorological factors were the greatest driver of PM2.5 pollution. In the short term, the rapid increase in population density, industrial emissions, industrial energy consumption, and total traffic emissions were the important driving factors of PM2.5 pollution in the coastal urban agglomerations of China. [ABSTRACT FROM AUTHOR]

Objective: The study is to examine the relationships between perceived initial cancer disclosure communication with doctors, levels of hope, and levels of trust in doctors among cancer patients in China.Methods: A total number of 192 cancer inpatients in a cancer hospital in China were surveyed. Perceived disclosure strategies, levels of hope, levels of trust in their doctors, as well as the demographic information were obtained from the participants.Results: In addition to age, patients who had higher levels of perceived emotional support from doctors, or higher levels of perceived personalized disclosure from doctors, or higher levels of perceived discussion of multiple treatment plans with doctors were more likely to have higher levels of trust in doctors. In addition to perceived health status, perceived emotional support from doctors significantly predicted participants' levels of hope. That is, patients who had higher higher levels of perceived doctors' emotional support were more likely to have higher levels of hope. Key disclosure person was a marginally significant variable, that is, patients who were mainly disclosed by family members might have higher levels of hope compared with patients who were mainly disclosed by doctors.Conclusions: When communicating with a cancer patient, doctors might not ignore the importance of emotional support during cancer diagnosis communication. Doctors might want to involve family and collaborate with family to find out ways of personalized disclosure. During the communication process, doctors could provide their patients with multiple treatment options and discuss the benefits and side effects of each treatment. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The main objective of this study is to investigate changes of features of rheumatic fever (RF) in recent 10 years. A total of 315 patients with RF during 1985–1995 (group 1) and 1997–2007(group 2) were selected. Their manifestations were compared. Results show that the female/male ratio was 2.0. Group 2 had higher rate of low-grade fever and carditis, and lower rate of heart failure, lower positive rate of C-reactive protein and antistreptolycin o than group 1. In group 2, 61.4% patients fulfilled the updated Jones criteria, however, 76.2% fulfilled 2002–2003 WHO criteria. Diagnosing rheumatic carditis, sensibility and specificity of lymphocyte procoagulant activity (PCA) were 79.1 and 71.4%, respectively, and those of antibody to streptococcal polysaccharide (ASP) were 70.3 and 70%, respectively. Follow-up data of 35 cases were available. Recurrent rate of RF was 62.8%. Only 1/3 cases received regular secondary prevention. In conclusion, mild carditis was increasing. PCA and ASP were valuable tests for diagnosing rheumatic carditis. Atypical cases and secondary prevention need more attention. [ABSTRACT FROM AUTHOR]

Background: The safety assessment and control of stacked transgenic crops is increasingly important due to continuous crop development and is urgently needed in China. The genetic stability of foreign genes and unintended effects are the primary problems encountered in safety assessment. Omics techniques are useful for addressing these problems. The stacked transgenic maize variety 12–5 × IE034, which has insect-resistant and glyphosate-tolerant traits, was developed via a breeding stack using 12–5 and IE034 as parents. Using 12–5 × IE034, its parents (12–5 and IE034), and different maize varieties as materials, we performed proteomic profiling, molecular characterization and a genetic stability analysis. Results: Our results showed that the copy number of foreign genes in 12–5 × IE034 is identical to that of its parents 12–5 and IE034. Foreign genes can be stably inherited over different generations. Proteomic profiling analysis found no newly expressed proteins in 12–5 × IE034, and the differences in protein expression between 12 and 5 × IE034 and its parents were within the range of variation of conventional maize varieties. The expression levels of key enzymes participating in the shikimic acid pathway which is related to glyphosate tolerance of 12–5 × IE034 were not significantly different from those of its parents or five conventional maize varieties, which indicated that without selective pressure by glyphosate, the introduced EPSPS synthase is not has a pronounced impact on the synthesis of aromatic amino acids in maize. Conclusions: Stacked-trait development via conventional breeding did not have an impact on the genetic stability of T-DNA, and the impact of stacked breeding on the maize proteome was less significant than that of genotypic differences. The results of this study provide a theoretical basis for the development of a safety assessment approach for stacked-trait transgenic crops in China. [ABSTRACT FROM AUTHOR]

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In the context of the cultural development of the new era and the burgeoning spiritual demands of the people, there has been a remarkable surge in the proliferation of traditional Chinese cultural programs. The “Chinese Festivals” series, produced by Henan TV, standing out as an engaging TV program that showcases traditional Chinese culture, has rapidly captivated a diverse audience across different age groups, creating a rich, multi-dimensional, and cross-media cultural communication ecosystem. The program strategically selects symbolic elements by systematically categorizing and organizing traditional Chinese cultural symbols to create a rich cultural space. It employs cutting-edge scientific and technological methods to enrich viewer immersion, crafting media rituals with both temporal significance and a profound sense of media ritual. This approach boosts the program’s popularity and sets a benchmark for industry innovation. By fostering an interactive narrative between mainstream media and the public, the program continuously broadens the scope of the “story world,” fostering a harmonious and structured national cultural community through the creative interpretation of traditional Chinese culture and the evocative crafting of the aesthetic sensibilities inherent in Chinese art. It is worth noting that the phenomenon of aesthetic fatigue besets the development of this serial program. To address this issue and further improve the appeal of the program, a comprehensive approach is required to develop a cohesive narrative mode for the “story world.” This involves harmonizing the interplay between artistic endeavors and technological advancements, synchronizing sensory experiences with the foundational ritualistic elements, and enhancing the effectiveness of the media communication matrix to construct a brand of media culture that has social significance, aesthetic value, and economic profits in the new era [ABSTRACT FROM AUTHOR]

As one of China's most significant neighbouring states, Vietnam has been a natural focus of Chinese scholars. This article analyses how Chinese scholars have interpreted changes in the Vietnamese political economy after 1975, usually characterized in English as a period of "reform" and "renovation" that created steady high economic growth in Vietnam. While Vietnamese reform has been positive, Chinese discourse on it has varied from criticizing it to using it as a reference point for Chinese reform. Although previous studies attributed these variations to fluctuating China-Vietnam relations, I argue that shifts in China's domestic reforms also played a role. [ABSTRACT FROM AUTHOR]

This article is a review of the book "Lineages Embedded in Temple Networks: Daoism and Local Society in Ming China" by Richard G. Wang. The book focuses on the expansion of Liu Yuanran's lineages in different areas of Ming China and explores the role of Daoism in local society during this time period. It discusses the relationships between local Daoist lineages and the central government, as well as the connections between Daoist temples and local society. The book also examines the influence of Liu Yuanran, a respected Daoist master, on the propagation of state-supported Daoist orthodoxy in the Ming empire. Overall, this book provides a comprehensive and well-researched study of Daoism in Ming China, making it a valuable resource for scholars interested in the religious landscape of the time period. [Extracted from the article]

INTRODUCTION The rapid growth of e-cigarette usage among youth and young people has emerged as a significant public health concern. It is imperative to initiate effective vaping prevention campaigns and undertake relevant research to address this pressing issue. This research seeks to identify effective video advertisements to deter young people from starting to use e-cigarettes. It aims to offer evidence-based insights and recommendations for creating communication materials and designing messages for youth e-cigarette prevention efforts. METHODS College students aged 18-24 years (n=40) participated in focus groups within this qualitative study. After viewing four stimulus videos, participants discussed what they perceived as effective and ineffective video characteristics, as well as suggestions for future videos. RESULTS Effective video characteristics included the use of real-life testimonials, displaying specific health hazards, revealing harmful chemical ingredients and the deceptive nature of flavors, and positively perceived effectiveness. Participants generally found that videos with strong visual impact and graphics were more engaging and that approaches using fear and emotion were more effective. Ineffective characteristics included complex and exaggerated information, lack of empathy and irrelevance, insufficiently specific information, extreme and death-themed content, industry messages, as well as preachy tones, animations, metaphors, dull formats, excessive length, and scenes of e-cigarette use. CONCLUSIONS Developing anti-e-cigarette campaign materials for youth necessitates target audience-focused qualitative research. This helps in deeply exploring and identifying effective themes and messages, as well as video characteristics and details while avoiding ineffective or even misleading messages and themes from young people's perspectives outside the United States. Future development of e-cigarette prevention videos for Chinese college students may consider incorporating localized real-life testimonial cases to convey specific harms, including self-efficacy information, and utilizing fear and emotional appeals. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the effects of nonpharmacological interventions (NPIs) on poststroke depression (PSD) in stroke patients. Methods: Computer searches were conducted on the PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Wanfang databases from their establishment to December 2023. The selection was made using the inclusion and exclusion criteria, and 40 articles were included to compare the effects of the 17 NPIs on patients with PSD. Results: Forty studies involving seventeen interventions were included. The network findings indicated that compared with conventional therapy (COT), superior PSD improvement was observed for cognitive behavioral therapy (CBT) + acupoint acupuncture (CBTA) (mean difference [MD], -4.25; 95% CI, -5.85 to -2.65), team positive psychotherapy (MD, -4.05; 95% CI, -5.53 to -2.58), music therapy (MT) + positive psychological intervention (MD, -2.25; 95% CI, -3.65 to -0.85), CBT (MD, -1.52; 95% CI, -2.05 to -0.99), mindfulness- based stress reduction (MD, -1.14; 95% CI, -2.14 to -0.14), MT (MD, -0.95; 95% CI, -1.39 to -0.52), acupoint acupuncture + MT (AAMT) (MD, -0.69; 95% CI, -1.25 to -0.14). Furthermore, CBT (MD, -3.87; 95% CI, -4.57 to -3.17), AAMT (MD, -1.02; 95% CI, -1.41 to -0.62), acupressure + MT (MD, -0.91; 95% CI, -1.27 to -0.54), and narrative care + acupressure (MD, -0.74; 95% CI, -1.19 to -0.29) demonstrated superior Pittsburgh Sleep Quality Index (PSQI) improvement compared with COT. Conclusion: Evidence from systematic reviews and meta-analyses suggests that CBTA improves depression in patients with PSD. Moreover, CBT improves sleep in these patients. Additional randomized controlled trials are required to further investigate the efficacy and mechanisms of these interventions. [ABSTRACT FROM AUTHOR]

Cui G-H, Yao Y-H, Xu R-F, Tang H-D, Jiang G-X, Wang Y, Wang G, Chen S-D, Cheng Q. Cognitive impairment using education-based cutoff points for CMMSE scores in elderly Chinese people of agricultural and rural Shanghai China. Acta Neurol Scand: 2011: 124: 361-367. © 2011 John Wiley & Sons A/S. Objectives - To evaluate cognitive impairment (CI) in rural China using the Chinese version of the Mini-Mental Status Examination (CMMSE) and compare the prevalence of CI using two different cutoff points. Materials & methods - A population-based survey was conducted of 2809 people aged 60 years and above in a community of two towns (Huaxin and Xujing) in the Qingpu district, located in the western suburb of Shanghai. Face-to-face interviews were carried out to collect relevant information with questionnaires. The Chinese version of the Mini-Mental State Examination with either a 23/24 cutoff point or a cutoff point varying according to education level (AEL) was used to screen subjects for CI. Results - Among these subjects, the mean age was 70.6 years (SD = 6.6) and ranged from 60 to 92 years and included 1010 (36.0%) men and 1799 (64.0%) women. The mean age was 70.7 years (SD = 6.4) for men and 70.5 years (SD = 6.7) for women. Of the 2809 subjects, 2010 (71.5%) had no formal education, 607 (21.6%) completed 1-6 years of education, and 173 (6.2%) completed more than 6 years of school education. The prevalence of CI was 35.6% (95% CI: 33.8-37.4) for both genders when the cutoff point of 23/24 was used. However, when the cutoff point was altered with respect to different education levels, the prevalence of CI was 7.0%. For each item of the CMMSE, increased years of education correlated with a higher item score, with the exception of the 'Naming' item score. Conclusions - This study demonstrates that screening of CI using the AEL cutoff scores is feasible in a low-education population. Determining whether the 23/24 cutoff point is suitable for the Chinese people requires future prospective studies in a large Chinese population. [ABSTRACT FROM AUTHOR]

Hemerocallis citrina Baroni (daylily) is an important cash crop in many regions of China. Daylily rust caused by Puccinia hemerocallidis (Ph) is a major disease in H. citrina. Rust infection on the leaves of two resistant and susceptible varieties of H. citrina was examined. Transcriptome sequencing and defense enzyme activity were used to analyze the differential expression of related genes after 0, 72, 144, 192, and 288 h, to reveal the response mechanism of H. citrina to rust infection and screen-related resistance genes. The results suggested that 72 h after Ph infection was the key time point for determining differences between resistant and susceptible varieties. DEGs were significantly enriched in phenylpropanoid biosynthesis, plant–pathogen interaction, plant hormone signal transduction, and the MAPK signaling pathway. TFs WRKY33 and CYP98A are key genes closely related to the disease-resistance response of H. citrina. This study is the first large-scale transcriptomic analysis of H. citrina. [ABSTRACT FROM AUTHOR]

Omicron variants have become the dominant SARS-CoV-2 variants due to their increased transmissibility and immune-escape ability. An outbreak of the Omicron variant BA.5.1.3 occurred in August 2022 in Sanya, China. Studying Omicron variants can promote the understanding of them and further contribute to managing the SARS-CoV-2 prevalence. This retrospective study analyzed the data of 258 patients with asymptomatic or mild SARS-CoV-2 admitted to the First Cabin Hospital of Sanya, China, between August 14 and September 4, 2022. The 258 patients comprised 128 males and 130 females with a mean age of 36.6 years and mean length of medical observation (LMO) of 10.1 days. Multiple linear regression analysis indicated that LMO was positively and negatively associated with age (p = 0.036) and vaccination status (p = 0.004), respectively. A Cox proportional-hazards model revealed that age (hazard ratio [HR] = 0.99, p = 0.029) and vaccination (HR = 1.23, p = 0.023) were risk and protective factors for LMO, respectively. Causal mediation analysis indicated that vaccination suppressed the effect of prolonging LMO caused by increasing age. Recovery times became longer with increasing age, which could be counterbalanced by vaccination. The present results indicate that vaccination interventions, even those developed through inactivated approaches, can still provide protection against Omicron variants. [ABSTRACT FROM AUTHOR]

Background: This study investigated the association of circulating tumor cells (CTCs) change during chemoradiation with the treatment response and survival profiles in advanced nonsmall-cell lung cancer (NSCLC) patients. Materials and Methods: Fifty-eight advanced NSCLC patients who underwent concurrent chemoradiation were enrolled; their peripheral blood samples were collected before chemoradiation, and at 1 month postchemoradiation, the CTCs were assayed using a CTC-Biopsy system. Moreover, CTCs were classified as CTCs positive and CTCs negative according to CTCs' count, and change of CTCs was calculated. In addition, response of chemoradiation was evaluated at 1 month postchemoradiation, then progression-free survival (PFS) and overall survival (OS) were assessed. Results: Prechemoradiation CTCs positive were associated with increased TNM stage, but not other clinicopathologic characteristics. After chemoradiation, the CTCs' number [1.0 (0.0–3.0) vs. 4.0 (2.0–10.0)] and the percentage of CTC-positive cases (37.9% vs. 77.6%) were both decreased compared to those before chemoradiation. Regarding treatment response, prechemoradiation CTCs positive were associated with lower partial response; postchemoradiation CTCs positive were associated with reduced disease control rate, while CTCs' change during chemoradiation was not associated with treatment response. Kaplan–Meier curves showed that postchemoradiation CTCs positive and increased CTCs' number during chemoradiation were associated with reduced PFS, then multivariate Cox's regression analysis disclosed that they independently predicted decreased PFS. However, no correlation of CTCs' status or CTCs' change with OS was observed. Conclusions: Prechemoradiation CTCs relate to increased TNM stage and worse prognosis in chemoradiation-treated advanced NSCLC patients. [ABSTRACT FROM AUTHOR]

According to recent research, after the Song dynasty, there was a transformation of the political culture in imperial China according to which Confucian elites and dynastic rulers ceased to construct political legitimacy by interpreting prophecies. By examining the process of how Zhu Yuanzhang, the founder of the Ming dynasty, utilized a popular prophecy and how he concealed his utilization of this prophecy after enthronement, this article offers a more nuanced narrative of the transformation. It shows that during the Yuan-Ming transition, rulers sought to employ prophecies to construct their image as sovereigns favoured by Heaven, but, ironically, in official writings rulers tended to hide their utilization of prophecies so as to highlight their virtues which deserved the Mandate of Heaven. This article argues that after the Song, the role of prophecies changed in the political arena—not from important to unimportant, but from officially recognized to officially concealed. [ABSTRACT FROM AUTHOR]

Cultural landscape security is important to national spatial and cultural security. However, compared with the many achievements in the study of ecological security, transregional cultural landscape security research lacks enough attention to match its importance. In the context of advocacy of 'connecting practices' between nature and culture in the field of international heritage conservation, this paper developed an approach for constructing transregional vernacular cultural landscape security patterns and identifying the key protected areas. A method is put forward based on the case of the Yangtze River Delta Demonstration Area, one of the fastest urbanizing regions in China, and included the following three steps: (1) analyze the core values of the transregional vernacular cultural landscape from a long-time series and multi-scale perspective; (2) integrate ecological security assessment and value security evaluation by combining qualitative with quantitative methods; (3) build a comprehensive vernacular cultural landscape security pattern to identify key protected areas and develop a zoning and grading conservation strategy toolkit. The results proved that our new method could effectively build a cross-regional network of integrated spatial and functional relationships between the historical cultural and natural landscape and have great significance in improving the level of transregional territorial spatial governance. [ABSTRACT FROM AUTHOR]

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Tianxia 天下 has recently become a buzzword in Chinese academia. The word's threefold connotation in relation to geographical, political, and international systems needs to be analyzed to illustrate its different meanings. These three meanings were centered around China in the self-sufficient traditional Chinese civilization; however, they all need reinterpretation in the current age of globalization. Reinterpreting tianxia requires an appropriate vehicle of language: weak and regressive language, early modern language that has undergone transformation, and pretentious usage cannot effectively reinterpret tianxia. A non-literati, nonpolitical approach to linguistic expression is necessary to avoid the corruption of language and reinterpret the word from a universal perspective. The principal matter to be addressed in reinterpreting tianxia is its notion in relationship to nationalism and cosmopolitanism. Merely reinterpreting the best intentions of tianxia is insufficiently convincing for the concept in the age of globalization. How tianxia is elucidated through the lens of the individual, state, and international world determines the reliability and credibility of the interpretation. [ABSTRACT FROM AUTHOR]

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Background: Brain Magnetic Resonance Imaging (MRI) examination of cerebral small vessel disease (CSVD) may help screen vascular cognitive impairment. A recently estimated CSVD score system was suggested to capture the overall CSVD burden. The study aimed to detect the association between systemic evaluation score of cerebral vascular imaging parameters with cognitive functions. Methods: This was a cross-sectional study in community settings. From October 2017 to September 2018, elder (≧60) residents were recruited through on-site visit in 6 communities from Shanghai, China. The participants underwent brain MRI, carotid ultrasound, laboratory tests of blood and urine samples. Cognitive function was evaluated using Mini-Mental State Examination (MMSE). MRI score of CSVD was calculated according to the 2012 standard for the evaluation of statistical changes in imaging. Results: Total 171 subjects completed survey and examinations. There were 55 participants diagnosed with cognitive impairment, with a total percentage of 32.2%. Participants with and without cognitive impairment showed significant differences in age, BMI and education level. Cognitive impaired participant had more disease history/comorbidity of hypertension and chronic renal insufficiency, higher level of creatinine, as well as lower level of full blood count (FBC) and alanine aminotransferase (ALT). A significant difference was detected in CSVD score between participants with and without cognitive impairment. Results of linear regression analysis showed significant negative correlations between MMSE score and both left and right carotid artery peak systolic velocity (PSV), however the CSVD score was only borderline (P = 0.0566) positively correlated with MMSE. Multivariate linear correlation analysis including all collected risk factor data showed that left carotid artery PSV score was among the independent negative correlated factors of MMSE. Multivariate binary logistic analysis showed that age, education and history of hypertension were the only statistically associated factors of cognitive impairment. Conclusions: The current study identified high prevalence of cognitive impairment in a Chinese community. In addition, correlations between cerebral vascular disease imaging status and cognitive functions were confirmed although the sample size limited the possibility of screening cognitive impairment with imaging technique. [ABSTRACT FROM AUTHOR]

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Background: H type hypertension is defined as homocysteine (Hcy) ≥ 10 μmol/L in combination with primary hypertension. Studies demonstrated that the existence of hyperhomocysteine (HHcy) in hypertensive exacerbates the poor outcome of cardiocerebral incidents. This study was to investigate the current epidemic situation of H type hypertension and determine the risk factors in order to find intervention targets for H type hypertensives.Methods: We conducted a cross-sectional study using cluster sampling design in Shanghai, China from July 2019 and April 2020. 23,652 patients with primary hypertension were enrolled in this study. Their medical information was recorded, and the level of Hcy concentrations and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms were detected.Results: In total, 22,731 of 23,652 patients were recorded. The mean age was 68.9 ± 8.6 y and 43% were men. 80.0% of the enrolled patients had H type hypertension. The frequency of allele T was 40.9%, and the proportions of the CC, CT, and TT genotypes were 36.1%, 46.0%, and 17.9%, respectively. Compared with the TT genotype, the plasma Hcy concentration levels were lower in patients with the CC/CT genotype (18.96 ± 13.48 μmol/L vs. 13.62 ± 5.20/14.28 ± 5.36, F = 75.04, p < 0.01). The risk for H type hypertension was higher in elderly people. Men had ~ 5.55-fold odds of H type hypertension compared with women. Patients with CT genotype and TT genotype had ~ 1.36- and ~ 2.76-fold odds of H type hypertension compared with those with CC genotype, respectively. Smoking and diabetes were not significantly associated with H type hypertension.Conclusions: The prevalence of H type hypertension in patients with primary hypertension was 80.0%, which was higher than the 75% found in prior report in China. Age, gender, and MTHFR C677T polymorphisms rather than smoking and diabetes were independently associated with H type hypertension. [ABSTRACT FROM AUTHOR]

A new generation of elites distinguished by their cultural endowments has emerged in China. Unlike the older generation of elites who signaled status through the display of wealth but shared similar tastes, the new generation of cultured elites has sophisticated, often Western‐oriented "highbrow" tastes in their cultural consumption. By comparing the upbringings and the tastes of interviewees from various backgrounds, this study suggests a widening taste‐chasm between the elites and the underclasses in urban cities. The social process behind this is argued to be the rapid formation of cultural capital in China, in which parental privileges accumulated in the market economy converted into cultural privileges in the new generation of new elites. [ABSTRACT FROM AUTHOR]

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This paper examines the basis of Asianist sympathy for 'New China', as the People's Republic was often styled, in the early 1950s by examining the writings of Indian diplomats, journalists and academics. These elite Indians either visited China as part of a 1951 delegation, making them witnesses to the ongoing New Democracy experiment. Since their experiences of China were definitely not comprehensive and hinged on the Chinese state's goodwill, the interesting question to ask is not whether these first-hand accounts of 'New China' were accurate but in what ways the Chinese revolution was made comprehensible in light of the Indian elite's own priorities as nation builders and social activists. This paper reconstructs major tropes of the Chinese revolution that appealed to Indian observers – self-sufficiency, empowerment of workers and peasants, a palpable sense of social vitality – and underscored their enthusiasm for Beijing. Most significantly, communism was subsumed in favourable accounts of 'New China' as a nation and society-building project. The Chinese revolution, the nature of which was still in flux, was absorbed into and understood through India and Asia's long struggle against Euro-American domination. In addition, the Chinese revolution was deployed as an example with which Indian observers assessed contemporary developments in their own country. The celebratory reception of 'New China' in India suggests that the subsequent rapport between the Chinese and Indian states was a result of not only high-level diplomatic manoeuvres but also pan-Asian epistemological bridging between socialist revolution and decolonization. [ABSTRACT FROM AUTHOR]

In the early twentieth century, approximately eighty-five percent of the Chinese population relied on agriculture for their livelihood. Aiming to improve the well-being of China's vast rural population, the Rockefeller Foundation (RF) made their own efforts through conducting philanthropy in rural China. The North China Council for Rural Reconstruction (NCCRR), a RF-funded rural philanthropic program composed of six Chinese institutions, was established in Peiping (Beijing) on April 2, 1936. As a nontraditional and experimental program, the NCCRR brought together the leading professors from various disciplines at different universities into intimate contact with philanthropic and educational activities in rural China. Although the program perhaps pointed to the modest ways in which institutions conducted rural philanthropy, the task of reviving China's countryside was ultimately too heavy for the RF as a foreign private foundation. Due to complicated circumstances far beyond their control, the RF had to terminate its rural reconstruction work in 1944. [ABSTRACT FROM AUTHOR]

Since the mid-nineteenth century, Chinese intellectuals turned to the West for truth. China's modern education system has since been built upon Western experience, with little space for China's vast indigenous intellectual traditions. Meanwhile, Chinese traditions remain omnipresent and ubiquitous in the society. Due to many fundamental differences, Chinese and Western traditions are not compatible with each other. Constant tensions between them have led to Chinese people's loss of spiritual homeland. Universities are both part of the reason for and a result of such a historical development. The shift of knowledge system from traditional learning to Western intellectual formation symbolizes the establishment of modern disciplines in Chinese universities. A better understanding of how traditional Chinese intellectual traditions were driven out of their homeland as Western knowledge became institutionalized is much needed in the literature. This article intends to fill the gap by exploring how the Chinese mind was transformed through the lens of institutionalization of social sciences. It focuses on internationalization and indigenization of China's social sciences with particular attention to the interactions between Chinese and Western intellectual traditions. [ABSTRACT FROM AUTHOR]

Copyright of China Quarterly is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The future of China's system of higher education will depend on which aspects of its past are most highly valued. This article explores the history of higher education in China from its ancient academies to the modern Western-influenced university. Although the May Fourth Movement of 1919 recommended the complete elimination of traditional elements in Chinese culture, the past century has revealed problems with the wholesale embrace of Western institutions. Modern higher education, based first on European models and later on American colleges and universities, has been a major part of the transformation of China in the past century. But cracks have appeared in the façade. The balance between tradition and innovation has been lost, students are being produced by universities like products of a factory assembly line, and college graduates often remain unemployed or underemployed for years after completing a degree. To remedy this condition, a number of reformers in China are looking to the past for answers. The article discusses both official and private experiments with 'organic' educational programs that aim at creating well-rounded persons, not merely students crammed with facts. A number of these new programs combine physical work with academic study as a reminder that life is a balance between mental and physical factors. More generally, the reform of modern education reclaims elements of the Chinese tradition that have been neglected, elements that recognize that education should ultimately aim at cultivating wisdom and not merely at accumulating knowledge. [ABSTRACT FROM AUTHOR]

This study examines whether sanctions imposed by the China Securities Regulatory Commission (CSRC) against individual auditors result in greater auditor conservatism. Using a difference-in-differences research design, we find that clients of sanctioned individual auditors have lower discretionary accruals in the post-sanction period than in the pre-sanction period when compared to a matched control group of clients audited by individual auditors who were not sanctioned. Our findings suggest that sanctions imposed by the CSRC on individual auditors can lead to improvements in audit quality by increasing the conservatism of the sanctioned auditors. That is, individual auditors are more likely to resist their clients' income-increasing accounting manipulations after being sanctioned by the CSRC. [ABSTRACT FROM AUTHOR]

Emergent events of urban rail transit may cause train delay, even service disruption, and then lead to a large number of passengers stranded. Urban rail transit system is difficult to maintain normal operation, so passengers shall be transported through other traffic modes outside the station. Traffic management plan outside the station is analyzed and evaluated in advance, which can increase evacuation efficiency and reduce the influence of events on society. The plan is evaluated through analyzing and simulation. Firstly, this paper analyzes the influence of events on traffic outside the station and introduces common means of traffic management. Then, this paper studies integrated simulation method and chooses key evaluation indicators, thus use the order of preference by similarity to ideal solution to evaluate the traffic management plan based on simulation. Finally, taking Jiangsu Road station as an example, this paper evaluates the effectiveness of different plans by simulation, the evaluation results show that plan 2 (partial priority) is optimal, which provides a reference for urban rail transit emergency management. [ABSTRACT FROM AUTHOR]

China has experienced an unprecedented level of farmland conversion for urban development despite the fact that farmland remains a highly scarce and valuable resource in this densely populated country. The causes of this presumably unreasonable phenomenon are examined from the perspective of competing claims for farmland conversion in Shanghai. The reasons behind such excessive farmland conversion for urban development in transitional China are generalized as follows: (1) the present urban-rural dualistic structure influences farmers to pursue economic rather than agricultural claims, (2) local governments with economic claims exercise strong incentives and power in converting farmland for urban purposes, (3) local governments largely undermine the enforcement of the central government's policies (which upholds agricultural claims), (4) other groups with noneconomic claims are excluded from the farmland conversion process, and (5) the village cadres and role model campaigns effectively reduce the conflict between farmers and local governments regarding the amount of compensation. Based on these findings, policy suggestions for farmland preservation are presented at the end of the paper. [ABSTRACT FROM AUTHOR]