1. Effect of naltrexone on ethanol-provoked flushing in Oriental and white subjects.
- Author
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Wilkin JK and Hazelrigg EJ
- Subjects
- Adult, Anthropology, Cultural, Anthropology, Physical, Cambodia ethnology, China ethnology, Clinical Trials as Topic, Female, Humans, Korea ethnology, Male, Philippines ethnology, Placebos, Rheology, Skin blood supply, Skin drug effects, United States, Vietnam ethnology, Asian People, Ethanol pharmacology, Flushing chemically induced, Naltrexone pharmacology, White People
- Abstract
The effect of naltrexone vs. placebo on alcohol-provoked flushing was studied in 20 healthy subjects of Oriental ancestry and 20 healthy white subjects. The intensity of the flushing reactions was assessed by two independent methods, the cutaneous perfusion index by laser Doppler velocimetry and the change in malar thermal circulation index by telethermometry. No effect of naltrexone on alcohol-provoked flushing was detected with either method in either racial group. The incidence of abdominal discomfort and nausea associated with naltrexone treatment was much greater among Orientals than whites.
- Published
- 1987
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